一种称为血管性水肿的医学病症的特征是粘膜突然肿胀,皮下组织,真皮,和粘膜下组织。如果气道阻塞导致呼吸窘迫,这种情况可能是致命的。组胺,缓激肽,和白三烯只是一些复杂的趋化介质,在血管性水肿的病理生理学中起作用,并可导致液体在更深的皮肤层积聚。很多事情,如药物副作用,遗传性疾病,和过敏反应,会引起血管性水肿.奥氮平,一种非典型的抗精神病药物,主要用于治疗一些精神障碍,是一种与血管性水肿有关的著名药物。血管性水肿是奥氮平的副作用,虽然罕见。尽管奥氮平引起血管性水肿的确切机制尚不清楚,认为涉及免疫介导的或特异性反应。本研究旨在回顾目前有关奥氮平与血管性水肿之间关系的文献。包括潜在的作用机制和对临床管理的影响。可能的风险因素,介绍,诊断,和奥氮平诱导的血管性水肿的治疗方案也将讨论。
A medical condition known as
angioedema is characterized by sudden swelling of the mucosa, subcutaneous tissue, dermis, and submucosal tissues. If airway obstruction results in respiratory distress, this condition may be fatal. Histamine, bradykinin, and leukotrienes are just a few of the complex chemotactic mediators that play a role in the pathophysiology of angioedema and can lead to fluid buildup in deeper skin layers. Many things, such as medication side effects, genetic disorders, and allergic reactions, can cause
angioedema. Olanzapine, an atypical antipsychotic mainly used to treat a few mental disorders, is one notable drug linked to angioedema.
Angioedema is a documented side effect of olanzapine, albeit rare. Although the exact mechanism by which olanzapine causes
angioedema is unknown, immunological-mediated or idiosyncratic reactions are thought to be involved. This study aims to review the current literature on the association between olanzapine and
angioedema, including potential mechanisms of action and implications for clinical management. The possible risk factors, presentation, diagnosis, and treatment options for olanzapine-induced angioedema will also be discussed.