PDF(Pubmed)
Abstract：
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for various conditions but are associated with numerous adverse drug reactions (ADRs). Understanding these ADRs is necessary to reduce morbidity and mortality. NSAID-induced angioedema, although rare, can be life-threatening and is often due to increased leukotriene production from COX pathway inhibition. Mast cells and basophil degranulation play vital roles in its pathogenesis. Prompt recognition and immediate cessation of the culprit drug, along with the administration of corticosteroids and antihistamines, are essential. Here, we report a case of angioedema caused by diclofenac administration, which needs prompt vigilance and a rapid therapeutic response.
摘要：
非甾体抗炎药（NSAID）广泛用于各种疾病，但与许多药物不良反应（ADR）有关。了解这些不良反应对于降低发病率和死亡率是必要的。NSAID诱导的血管性水肿,虽然罕见，可能危及生命，并且通常是由于COX途径抑制产生的白三烯增加。肥大细胞和嗜碱性粒细胞脱颗粒在其发病机制中起着至关重要的作用。迅速识别并立即停止犯罪药物，伴随着皮质类固醇和抗组胺药的服用，是必不可少的。这里,我们报告一例由双氯芬酸引起的血管性水肿，这需要迅速的警惕和快速的治疗反应。
