■羊水炎症生物标志物与中期或中期妊娠早产的关系一直是人们关注的焦点,了解这些标志物与早产的相关性对于早产的早期识别和干预具有重要意义。这项研究的目的是探索与早产相关的妊娠中期或中期妊娠羊水中潜在的炎症生物标志物。
■2023年11月30日,我们通过PubMed搜索了涉及妊娠中期或中期妊娠羊水炎症生物标志物对早产影响的文献,WebofScience,Embase,范围,CNKI,万方,VIP和中国生物医学数据库。搜索语言为中文和英文。纳入的结果指标通过R软件进行综合效用分析。
■共有11篇文章被纳入综合效用分析。该组合分析显示,两组之间羊水中几种炎症生物标志物的显着差异(MD=6.87,95CI:0.26-13.47,P<0.01);两组之间的羊水IL-6的差异(MD=5.73,95CI:3.13-8.32,P<0.01);两组之间的羊水IL-10的差异(MD=0.11-9548,P=0.01)两组之间的差异在羊水之间的差异
■炎症生物标志物IL-1β,IL-6,IL-10,CRP,TNFα,妊娠中晚期羊水中的MCP-1和MMP-9均与早产有关。
由于未成熟的器官,早产胎儿在近期和长期都有许多严重的并发症,这与脑瘫的长期发病率有关,发育迟缓和早产儿视网膜病变,这是围产期胎儿死亡的主要原因。早产病例伴有羊膜腔内病原微生物感染,然后导致羊膜腔的炎症反应。然而,炎症标志物与早产的相关性研究显示出一定的复杂性和差异性。这项荟萃分析的结果表明,炎症生物标志物白细胞介素-1β(IL-1β),白细胞介素-6(IL-6)和白细胞介素-10(IL-10),C反应蛋白(CRP),肿瘤坏死因子-α(TNF-α),妊娠中期或晚期患者羊水中的单核细胞趋化蛋白-1(MCP-1)和基质金属蛋白酶-9(MMP-9)在早产组与对照组之间有显著差异,早产组羊水中炎性因子的表达水平升高,因此提示这些炎症因子可能能够预测早产。
UNASSIGNED: The relationship between amniotic fluid inflammatory biomarkers and preterm birth in second- or third-trimester pregnancy has been a focus, and understanding the correlation between these markers and preterm birth is important for early identification and intervention in preterm birth. The aim of this study was to explore potential inflammatory biomarkers in second- or third-trimester pregnancy amniotic fluid associated with preterm birth.
UNASSIGNED: On November 30, 2023, we searched literature involved the influence of second- or third-trimester pregnancy amniotic fluid inflammatory biomarkers on preterm birth through PubMed, Web of Science, Embase, Scope, CNKI, WanFang, VIP and China Biomedical Databases. The search languages were Chinese and English. Included outcomes indexes were combined utility analysis via R software.
UNASSIGNED: A total of 11 articles were included in the combined utility analysis. This combined analysis revealed significant differences in several inflammatory biomarkers in amniotic fluid between the two groups (MD = 6.87, 95%CI: 0.26 - 13.47, P < 0.01); the difference in amniotic fluid IL-6 between the two groups (MD = 5.73, 95%CI: 3.13-8.32, P < 0.01); the difference in amniotic fluid IL-10 between the two groups (MD = 0.11, 95%CI: -3.26-3.48, P < 0.01); the difference in amniotic fluid CRP between the two groups (MD = 21.34, 95%CI: 11.69-30.89, P < 0.01); the difference in amniotic fluid MCP-1 between the two groups (MD = 312.14, 95%CI: 211.34-412.97, P < 0.01); the difference in the amniotic fluid MMP-9 between the two groups (MD = 0.86, 95%CI: -0.10-1.82, P < 0.01); and the difference in TNF-α in amniotic fluid between the two groups (MD = 22.78, 95%CI: -5.05-50.61, P < 0.01).
UNASSIGNED: The inflammatory biomarkers IL-1β, IL-6, IL-10, CRP, TNFα, MCP-1 and MMP-9 in the amniotic fluid of patients in the second- or third-trimester pregnancy were all correlated with preterm birth.
The premature foetus has many serious complications in the near and long term because of the immature organs, which is related to the long-term incidence of cerebral palsy, developmental delay and retinopathy of prematurity, which is the main cause of perinatal foetal death. Preterm birth cases are accompanied by infection of pathogenic microorganisms in amniotic cavity, which then leads to inflammatory reaction in amniotic cavity. However, research on the correlation between inflammatory markers and preterm birth has shown certain complexity and differences. The results of this meta-analysis show that the inflammatory biomarkers interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10), C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and matrix metalloproteinase-9 (MMP-9) in amniotic fluid of patients in the second- or third-trimester pregnancy are significant between the preterm birth group and the control group, and the expression level of inflammatory factors in amniotic fluid of patients in the preterm birth group is elevated, thus suggesting that these inflammatory factors may be able to predict preterm birth.