PDF(Pubmed)
Abstract：
UNASSIGNED: Proinflammatory chemokines have been shown to play crucial roles in implantation, spiral artery invasion, and the fetomaternal immunological response. In this context, we investigated the levels of fractalkine (CX3CL1) and chemokine CC motif ligand 4 (CCL4 or MIP-1β) in maternal serum and amniotic fluids in pregnant women with intrauterine growth restriction (IUGR).
UNASSIGNED: This prospective cohort study was carried out at Fırat University Obstetrics Clinic between January 1, 2022 and July 1, 2022. Group (G) 1: The control group consisted of 40 pregnant women who underwent elective cesarean section (CS) at 38-40 weeks of gestation. G2: A total of 40 pregnant women with IUGR at 28-37 weeks of gestation were included in the study group. Levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interferon-gamma (IFN-γ), hypoxia-inducible factor-1 alpha (HIF-1α), macrophage inflammatory protein-1 beta (MIP-1β), and fractalkine were measured in maternal serum and amniotic fluid samples obtained during CS.
UNASSIGNED: When maternal age was compared, no statistically significant difference was observed between G1 and G2 (p = 0.374). The number of gravidity was found to be statistically higher in G1 compared to G2 (p = 0.003). The mean gestational week was statistically higher in G1 (p < 0.001). Maternal serum MIP-1β (p = 0.03) and IFN-γ (p = 0.006) levels were higher in G1. The birth weight of the baby (p < 0.001) and umbilical cord blood gas pH value (p < 0.001) at birth were higher in G1. HIF-1α (p < 0.001), fractalkine (p < 0.001), MIP-1β (p < 0.001), TNF-α (p = 0.007), IL-1β (p < 0.001), and IFN-γ levels (p = 0.007) in amniotic fluid were higher in G2.
UNASSIGNED: Elevated levels of proinflammatory factors, including fractalkine and MIP-1β, along with inflammatory factors such as TNF-α, IL-1β, and IFN-γ, as well as increased HIF-1α levels in amniotic fluid, are associated with intrauterine growth restriction (IUGR) attributed to a hypoxic amniotic environment.
UNASSIGNED: This prospective cohort study was carried out at Fırat University Obstetrics Clinic between January 1, 2022 and July 1, 2022. Group (G) 1: The control group consisted of 40 pregnant women who underwent elective cesarean section (CS) at 38-40 weeks of gestation. G2: A total of 40 pregnant women with IUGR at 28-37 weeks of gestation were included in the study group. Levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interferon-gamma (IFN-γ), hypoxia-inducible factor-1 alpha (HIF-1α), macrophage inflammatory protein-1 beta (MIP-1β), and fractalkine were measured in maternal serum and amniotic fluid samples obtained during CS.
UNASSIGNED: When maternal age was compared, no statistically significant difference was observed between G1 and G2 (p = 0.374). The number of gravidity was found to be statistically higher in G1 compared to G2 (p = 0.003). The mean gestational week was statistically higher in G1 (p < 0.001). Maternal serum MIP-1β (p = 0.03) and IFN-γ (p = 0.006) levels were higher in G1. The birth weight of the baby (p < 0.001) and umbilical cord blood gas pH value (p < 0.001) at birth were higher in G1. HIF-1α (p < 0.001), fractalkine (p < 0.001), MIP-1β (p < 0.001), TNF-α (p = 0.007), IL-1β (p < 0.001), and IFN-γ levels (p = 0.007) in amniotic fluid were higher in G2.
UNASSIGNED: Elevated levels of proinflammatory factors, including fractalkine and MIP-1β, along with inflammatory factors such as TNF-α, IL-1β, and IFN-γ, as well as increased HIF-1α levels in amniotic fluid, are associated with intrauterine growth restriction (IUGR) attributed to a hypoxic amniotic environment.
摘要：
■促炎趋化因子已被证明在植入中起关键作用，螺旋动脉侵入,和胎儿的免疫反应。在这种情况下，我们调查了宫内生长受限(IUGR)孕妇血清和羊水中Fractalkine(CX3CL1)和趋化因子CC基序配体4(CCL4或MIP-1β)的水平.
■这项前瞻性队列研究是在2022年1月1日至2022年7月1日之间在费拉特大学妇产科诊所进行的。组（G）1：对照组由40名孕妇组成，这些孕妇在妊娠38-40周时进行了选择性剖宫产（CS）。G2:总共40名妊娠28-37周时患有IUGR的孕妇被包括在研究组中。肿瘤坏死因子-α(TNF-α)水平,白细胞介素-1β（IL-1β），干扰素-γ（IFN-γ），缺氧诱导因子-1α(HIF-1α),巨噬细胞炎性蛋白-1β（MIP-1β），在CS期间获得的母体血清和羊水样本中测量了fractalkine。
■当比较产妇年龄时，在G1和G2之间没有观察到统计学上的显著差异(p=0.374)。与G2相比，G1中的妊娠次数在统计学上较高（p=0.003）。G1的平均孕周在统计学上较高(p<0.001)。孕妇血清MIP-1β（p=0.03）和IFN-γ（p=0.006）水平在G1期较高。婴儿出生体重(p<0.001)和出生时脐血气体pH值(p<0.001)在G1时较高。HIF-1α（p<0.001），Fractalkine(p<0.001)，MIP-1β（p<0.001），TNF-α（p=0.007），IL-1β（p<0.001），G2期羊水中IFN-γ水平较高(p=0.007)。
■促炎因子水平升高，包括Fractalkine和MIP-1β，随着炎症因子如TNF-α，IL-1β,和IFN-γ，以及羊水中HIF-1α水平升高，与归因于羊水缺氧环境的宫内生长受限（IUGR）有关。
■这项前瞻性队列研究是在2022年1月1日至2022年7月1日之间在费拉特大学妇产科诊所进行的。组（G）1：对照组由40名孕妇组成，这些孕妇在妊娠38-40周时进行了选择性剖宫产（CS）。G2:总共40名妊娠28-37周时患有IUGR的孕妇被包括在研究组中。肿瘤坏死因子-α(TNF-α)水平,白细胞介素-1β（IL-1β），干扰素-γ（IFN-γ），缺氧诱导因子-1α(HIF-1α),巨噬细胞炎性蛋白-1β（MIP-1β），在CS期间获得的母体血清和羊水样本中测量了fractalkine。
■当比较产妇年龄时，在G1和G2之间没有观察到统计学上的显著差异(p=0.374)。与G2相比，G1中的妊娠次数在统计学上较高（p=0.003）。G1的平均孕周在统计学上较高(p<0.001)。孕妇血清MIP-1β（p=0.03）和IFN-γ（p=0.006）水平在G1期较高。婴儿出生体重(p<0.001)和出生时脐血气体pH值(p<0.001)在G1时较高。HIF-1α（p<0.001），Fractalkine(p<0.001)，MIP-1β（p<0.001），TNF-α（p=0.007），IL-1β（p<0.001），G2期羊水中IFN-γ水平较高(p=0.007)。
■促炎因子水平升高，包括Fractalkine和MIP-1β，随着炎症因子如TNF-α，IL-1β,和IFN-γ，以及羊水中HIF-1α水平升高，与归因于羊水缺氧环境的宫内生长受限（IUGR）有关。
