Vitamin D3

维生素 D3
  • DOI:
    文章类型: Case Reports
    过敏性紫癜(HSP)是一种免疫球蛋白A(IgA)介导的系统性血管炎,这是乙肝疫苗接种的罕见不良反应之一。发现大多数HSP患者存在低维生素D水平。2020年1月,一名19岁妇女因双侧下肢紫癜性皮疹和左食指关节痛而入院。在患者接受第一剂重组乙型肝炎疫苗接种后一周发生皮疹史。常规血液学检查,肌酐,尿液分析,C3和C4显示正常结果。HBsAg,抗HCV,ANA检测结果为阴性,和抗HBs升高。维生素D很低。患者诊断为HSP,给予霉酚酸酯,甲基强的松龙,维生素D3和叶酸。治疗后1个月内,皮疹仍然经常发生,所以霉酚酸酯被改为霉酚酸,增加甲基强的松龙的剂量并给予非索非那定.在接下来的3个月里,皮疹有所改善。然而,患者报告膝关节疼痛和脱发。2021年5月,由于慢性扁桃体炎急性加重,患者接受了扁桃体切除术。此后,患者报告皮疹已完全消退,从未恶化,维生素D检测结果正常。乙肝疫苗接种是HSP的病因之一,虽然很罕见,因此,询问疑似HSP患者的疫苗接种史很重要。在该患者的HSP病例中,维生素D的校正和扁桃体切除术可提供更好的治疗结果。
    Henoch-Schönlein purpura (HSP) is an immunoglobulin A (IgA)-mediated systemic vasculitis, which is one of the rare adverse reactions to hepatitis B vaccination. Low vitamin D levels were found to be present in the majority of HSP patients.A 19-year-old woman was admitted with a purpuric rash on bilateral lower limbs and joint pain on her left index finger in January 2020. A previous history of rash occurred one week after the patient received her first dose of recombinant hepatitis-B vaccination. Routine hematological examination, creatinine, urinalysis, C3, and C4 showed normal results. HBsAg, Anti-HCV, and ANA tests were negative, and anti-HBs were elevated. Vitamin D is very low. The patient was diagnosed with HSP and given mycophenolate mofetil, methylprednisolone, vitamin D3, and folic acid. Within 1 month of therapy, the rash still occurred frequently, so mycophenolate mofetil was changed to mycophenolic acid, the dose of methylprednisolone was increased and fexofenadine was administered. In the next 3 months, the rash has improved. However, patients reported knee joint pain and hair loss. In May 2021, the patient underwent tonsillectomy due to acute exacerbation of chronic tonsillitis. Thereafter, the patient reported that the rash had completely resolved and never worsened, and the vitamin D assay was normal.Hepatitis B vaccination is one of the etiologies of HSP, although it is rare, so it is important to ask about the vaccination history in patients with suspected HSP. Correction of vitamin D and performing tonsillectomy provide better treatment results in HSP cases in this patient.
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  • 文章类型: Journal Article
    川崎病(KD)是一种以全身性小血管炎为特征的儿科血管疾病,尤其是冠状动脉炎,发病机制不清楚。这项探索性病例对照研究调查了叶酸(FA)、维生素D3(VD3),和维生素B12(VB12)水平和不同类型的川崎病,以及冠状动脉病变(CAL)的发生率。
    在这项探索性病例对照研究中,从2022年1月1日至2023年6月30日入住我们医院的365名KD儿童被纳入KD组。同时,以同期接受体检的健康儿童365例为对照组。KD组分为典型KD组和不完全KD组(IKD组),CALS组和非CALS组,IVIG敏感组和IVIG耐药组。将CAL患儿分为小肿瘤组,中肿瘤组和大肿瘤组。血清FA水平,比较所有组的VB12和VD3。
    KD组和CAL组的血清FA和VD3水平均显着降低(p<0.05),这两个因素均被确定为KD和CAL的独立危险因素。同样,在IKD和IVIG耐药组中观察到血清VD3水平降低(p<0.05),VD3也是IKD和IVIG耐药的独立危险因素。此外,在大动脉瘤组血清FA水平较低(p<0.05),确定FA是动脉瘤大小的独立危险因素。
    KD患儿血清叶酸FA和维生素VD3水平显著降低。此外,这些减少在IKD和CAL患儿中更为明显.这种模式表明,较低的FA和VD3水平可能会增加KD患者发生更严重冠状动脉病变的风险。因此,监测这些生物标志物可以为早期临床诊断和干预提供有价值的见解.
    UNASSIGNED: Kawasaki Disease (KD) is a pediatric vasculitic disorder characterized by systemic small vasculitis, notably coronary arteritis, with unclear pathogenesis. This explorative case-control study investigated the association between folic acid (FA), vitamin D3 (VD3), and vitamin B12 (VB12) levels and the different types of Kawasaki Disease, as well as the incidence of coronary artery lesions (CALs).
    UNASSIGNED: In this explorative case control study, 365 KD children admitted to our hospital from January 1, 2022 to June 30, 2023 were included as the KD group. Simultaneously, 365 healthy children who received physical examination during the same period were included as the control group. The KD group was divided into typical KD group and incomplete KD group (IKD group), CALs group and non-CALS group, and IVIG sensitive group and IVIG resistant group. The children with CALs were divided into small tumor group, medium tumor group and large tumor group. Serum levels of FA, VB12, and VD3 were compared across all groups.
    UNASSIGNED: Serum levels of FA and VD3 were significantly decreased in both the KD and CALs groups (p < 0.05), and both factors were identified as independent risk factors for KD and CALs. Similarly, reduced serum VD3 levels were observed in the IKD and IVIG-resistant groups (p < 0.05), with VD3 also being an independent risk factor for both IKD and IVIG resistance. Additionally, lower serum FA levels were noted in the group with large aneurysms (p < 0.05), establishing FA as an independent risk factor for aneurysm size.
    UNASSIGNED: Serum levels of folic FA and vitamin VD3 were significantly reduced in children with KD. Furthermore, these reductions were more pronounced in children with IKD and CALs. This pattern suggests that lower FA and VD3 levels may increase the risk of more severe coronary lesions in KD patients. Therefore, monitoring these biomarkers could provide valuable insights for early clinical diagnosis and intervention.
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  • 文章类型: Journal Article
    外阴阴道念珠菌病(VVC)是一种真菌感染,是一个全球性的妇女健康问题,由于其与发病率相关,不孕症,和经济成本。这项研究旨在比较VVC女性与健康对照之间的维生素D3水平,并确定分离株的物种分布和易感性模式。使用ITS-rDNA区域的测序和HWP1基因的扩增进行物种鉴定。抗真菌药敏试验通过圆盘扩散法测定。此外,采用市售ELISA(酶联免疫吸附测定)试剂盒测定血清维生素D3水平.我们的结果表明,VVC女性的维生素D3水平低于健康女性(p值<.001)。白色念珠菌复合体(62.8%)是最常见的物种,大多数物种对氟康唑敏感,伊曲康唑,酮康唑,还有制霉菌素.总之,我们的研究揭示了女性维生素D3缺乏与VVC之间的潜在联系.尽管我们的研究结果显示,VVC女性的维生素D3水平明显降低,需要进一步的研究来确定维生素D3缺乏与VVC之间的明确因果关系.尽管如此,我们的研究强调了维持维生素D3充足水平的潜在重要性,以及在这方面需要进一步探索.
    Vulvovaginal candidiasis (VVC) is a fungal infection that is a global issue of women\'s health due to its association with morbidity, infertility, and economic costs. This study aimed to compare the vitamin D3 levels between women with VVC to healthy controls and determine the species distribution and susceptibility pattern of isolates. Species identification was performed using sequencing of the ITS-rDNA regions and amplification of the HWP1 gene. Antifungal susceptibility testing was determined by the disk diffusion method. Moreover, serum vitamin D3 levels were measured using a commercial ELISA (enzyme-linked immunosorbent assay) kit. Our results indicated that vitamin D3 level in women with VVC was lower than those of healthy women (p-value < .001). Candida albicans complex (62.8 percent) was the most common species, and most species were susceptible to fluconazole, itraconazole, ketoconazole, and nystatin. In conclusion, our study revealed a potential link between vitamin D3 deficiency and VVC in women. Although our findings showed significantly lower vitamin D3 levels in women with VVC, further research is needed to establish a definitive causative relationship between vitamin D3 deficiency and VVC. Nonetheless, our study highlights the potential importance of maintaining adequate levels of vitamin D3 and the need for further exploration in this area.
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  • 文章类型: Journal Article
    室内爬虫对紫外线辐照度的修改会影响行为和生理。低紫外线B(UVB)辐射可导致维生素D3缺乏,导致钙代谢紊乱,包括代谢性骨病和免疫抑制。高UVB会导致皮肤和眼睛问题,严重到足以导致休克和死亡.使用可用于评估紫外线的工具,包括弗格森区和英国和爱尔兰动物园和水族馆协会设计的紫外线工作工具,我们重新设计了室内科莫多龙(Varanuskomodoensis)栖息地的照明,以更好地适应该物种的紫外线要求,同时研究行为和生理学的变化。我们测量了一只雄性和一只雌性科莫多龙在室内和室外栖息地之前和之后的血清维生素25-羟基D3值。我们还测量了我们的雄性科莫多从户外栖息地移动时的行为变化,改变紫外线辐照度的室内栖息地。我们的女性科莫多在户外移动后显示维生素D3值增加了98%,下了她的第一个鸡蛋。我们的男性龙的维生素D3在室内移动200天后保持一致。当更高的UV辐照度可用时,他确实显示出增加的活性。重要的是,我们发现我们使用的紫外线灯在正常使用3.5个月内停止产生所需的紫外线辐照度。我们建议所有动物护理机构制定紫外线监测计划,以研究室内爬虫栖息地使用的UVB灯的输出和寿命。
    Modifications to UV irradiance for indoor housed herpetofauna can affect behavior and physiology. Low ultraviolet B (UVB) irradiance can result in vitamin D3 deficiency resulting in calcium metabolism disorders including metabolic bone disease and immune suppression. High UVB can result in skin and eye issues, which can be severe enough to cause shock and death. Using tools available for the assessment of UV light, including Ferguson zones and the UV working tool designed by the British and Irish Association of Zoos and Aquaria, we redesigned lighting in our indoor komodo dragon (Varanus komodoensis) habitat to better suit the UV requirements of this species, while studying changes in behavior and physiology. We measured serum vitamin 25-hydroxy D3 values in one male and one female komodo dragon before and after they were housed in indoor and outdoor habitats. We also measured behavior changes in our male komodo as he moved from an outdoor habitat, to an indoor habitat with changing UV irradiance. Our female komodo showed a 98% increase in vitamin D3 values after being moved outdoors, and laid her first clutch of eggs. Our male dragon\'s vitamin D3 remained consistent 200 days after moving inside. He did show increased activity when higher UV irradiance was available. Importantly, we found the UV lamps we used stopped producing desired UV irradiance within 3.5 months of regular use. We suggest all animal care facilities develop UV monitoring programs to research output and longevity of UVB lamps used in indoor herpetofauna habitats.
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  • 文章类型: Journal Article
    (1)目的:这项前瞻性病例对照研究旨在评估阻塞性睡眠呼吸暂停(OSA)儿童非过敏性患者和健康对照组的血清维生素D水平。(2)方法:入学时间为2021年11月至2022年2月。招募由腺扁桃体肥大(ATH)引起的无并发症OSA儿童。皮肤点刺试验(SPT)排除过敏,ELISA法测定血清IgE水平。定量测定25-羟基维生素D(25-OHD)的血浆浓度;然后,将患者的维生素D浓度与性别匹配的健康对照进行比较,年龄,种族,和特点。(3)结果:患者血浆25-OHD水平明显低于健康受试者(平均17ng/mL,6.27DS,范围6-30.7ng/mL,vs.平均22ng/mL,9.45DS,范围7-41.2ng/ml;p<0.0005)。ATH组儿童维生素D缺乏的患病率明显高于对照组。血浆25-OHD水平在ATH临床表现后没有变化(根据Brodsky量表的III或IV级),而不同类别的25-OHD状态(不足,缺乏,和充分性)在ATH组中与健康对照组有统计学显着差异(p<0.001)。(4)结论:本研究发现ATH组和对照组在维生素D血浆浓度方面存在统计学上的显着差异;该数据,尽管不能直接链接到淋巴组织肥大(P值不显著),可能提示维生素D缺乏对免疫系统的负面影响。
    (1) Objective: This prospective case-control study aimed to assess the level of serum vitamin D comparing pediatric non-allergic patients with obstructive sleep apnea (OSA) and healthy controls. (2) Methods: The period of the enrollment was from November 2021 to February 2022. Children with uncomplicated OSA caused by adenotonsillar hypertrophy (ATH) were recruited. Allergy was excluded by skin prick test (SPT), and the determination of serum IgE level using ELISA test. Plasma concentration of 25-hydroxy vitamin D (25-OHD) was quantitatively determined; then, the vitamin D concentration in patients was compared with healthy controls matched for sex, age, ethnicity, and characteristics. (3) Results: Plasma 25-OHD levels were significantly lower in patients than in healthy subjects (mean 17 ng/mL, 6.27 DS, range 6-30.7 ng/mL, vs. mean 22 ng/mL, 9.45 DS, range 7-41.2 ng/ ml; p < 0.0005). The prevalence of children with vitamin D deficiency was significantly higher in the ATH group than controls. The plasma 25-OHD level did not change following the ATH clinical presentation (III or IV grade according to the Brodsky scale), while the different categories of 25-OHD status (insufficiency, deficiency, and adequacy) in the ATH group were statistically significantly different (p < 0.001) from healthy controls. (4) Conclusions: This study identified statistically significant differences between the ATH group and control regarding the plasma concentration of vitamin D; this data, despite not being directly linkable to the lymphoid tissue hypertrophy (p-value not significant), might suggest a negative effect of vitamin D deficit on the immune system.
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  • DOI:
    文章类型: Journal Article
    目的:人类肺部的流感大流行是在100多年前的1918年由甲型H1N1流感引起的,但在2009年以大流行的方式复发。了解这种感染因子在人肺中的病理生物学可以导致相对无毒的辅助治疗并降低人宿主的死亡率。总的来说,我们的目的是将形态蛋白质组学应用于尸检患者的肺切片,以便我们可以从其与宿主相互作用的角度更好地定义其生物学特性,并为治疗靶点提供选择.
    方法:此次甲型H1N1流感肺部感染病例的形态蛋白质组学分析包括免疫组织化学探针检测脂肪酸合成酶(FAS)的表达,CD163+(M2极化单核细胞/巨噬细胞),和程序性死亡配体1(PD-L1)表达作为宿主对与流感A(H1N1)病毒相互作用的反应的一部分。
    结果:甲型流感(H1N1)受害者肺的代表性切片显示:大多数脱落和非典型肺泡肺细胞中FAS的细胞质表达;肺泡内和肺泡间质CD163巨噬细胞/单核细胞的丰度;以及偶尔巨噬细胞上的PD-L1表达,并集中在肺泡肺细胞和肺泡间质的集合上。
    结论:形态蛋白质组学和显微解剖特征与甲型H1N1肺部流感感染的致病特征和宿主反应一致。这加上医学文献的数据挖掘表明,辅助,二甲双胍和维生素D3等靶向治疗可以解决甲型H1N1流感肺炎的生物学问题,增强宿主的免疫反应,并防止其发展为危及生命的人,呼吸机依赖的临床情况。
    OBJECTIVE: Influenza pandemic of the human lung was caused by the Influenza A (H1N1) over 100 years ago in 1918, but it recurred in pandemic fashion in 2009. Understanding the pathobiology of this infectious agent in the human lung could lead to adjuvant therapies that are relatively non-toxic and reduce the mortality of the human host. Overall, our objective was to apply morphoproteomics to pulmonary lung sections from an autopsied victim so that we may better define its biology from the perspective of its interaction with the host and provide options for therapeutic targets.
    METHODS: Morphoproteomic analysis from a case study of this Influenza A (H1N1) pulmonary infection included immunohistochemical probes to detect the expressions of fatty acid synthase (FAS), CD163+ (M2 polarized monocytes/macrophages), and programmed death-ligand 1 (PD-L1) expression as part of the host response to interaction with the Influenza A (H1N1) virus.
    RESULTS: Representative sections of the Influenza A (H1N1) victim\'s lung showed: cytoplasmic expression of FAS in most of the sloughed and atypical alveolar pneumocytes; abundance of intra-alveolar and alveolar interstitial CD163+ macrophages/monocytes; and PD-L1 expression on occasional macrophages, and focally on collections of alveolar pneumocytes and the alveolar interstitium.
    CONCLUSIONS: Morphoproteomics and microanatomical features coincide with the etiopathogenic features of pulmonary Influenza A (H1N1) infection and the host response. This plus data mining of the medical literature suggests that adjunctive, targeted therapy such as metformin and vitamin D3 could address the biology of Influenza A (H1N1) pneumonia, enhance the host immune response, and prevent its progression to a life-threatening, ventilator-dependent clinical situation.
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  • 文章类型: Journal Article
    目的:本研究旨在对比和比较血清铁蛋白,血红蛋白,维生素D3,Ca++,促甲状腺激素释放激素(TRH),严重龋齿(SC)学龄前儿童之间的血清白蛋白水平以及控制龋齿的措施。
    方法:选择了300名儿童的样本量,但只有266名参与;54.14%的SC和45.86%的无龋。血清铁蛋白的血样,血红蛋白,维生素D3,Ca++,TRH,和血清白蛋白水平。
    结果:平均年龄估计为40.82±14.09个月。样本受检者的血清铁蛋白水平估计平均值为29.58±17.87μg/L,而测量的血红蛋白水平平均值为115.13±10.12g/L。Logistic回归分析(LRA)表明,与龋齿控制儿童相比,SC儿童的铁蛋白水平下降的可能性几乎是后者的两倍,并且FeDA(缺铁性贫血)的可能性可能是后者的六倍。SC患儿的平均维生素D3值显着降低(p<0.001),Ca++(p<0.001),和血清白蛋白(p<0.001)水平,促甲状腺激素释放因子(p<0.001)水平明显高于无龋齿的受试者。
    结论:对年龄很小的SC患儿的分析显示,与无龋齿的口腔患儿相比,低铁蛋白水平的机会增加。患有SC的儿童在很小的时候血红蛋白水平就不足。与没有龋齿的儿童相比,患有SC的儿童在很小的时候似乎营养不良。其他对比参数,如FeDA,维生素D3,Ca++,和血清白蛋白浓度显着不足SC儿童在很小的时候,相比之下,一个没有龋齿的孩子的样本。分析还表明TRH水平增加。
    结论:以下研究为牙科兄弟会和其他健康专家分析血清铁蛋白树立了基准,血红蛋白,维生素D3,Ca++,TRH,和血清白蛋白水平,而一般治疗儿科患者。因此,即使在龋齿中,也应合理地规定补充剂。
    JhaA,JhaS,ShreeR,etal.血清铁蛋白,血红蛋白,维生素D3,血清白蛋白,钙,促甲状腺激素释放激素与早期儿童龋齿的病例对照研究.IntJClinPediatrDent2021;14(5):648-651。
    OBJECTIVE: This study aimed to contrast and compare serum ferritin, hemoglobin, Vitamin D3, Ca++, thyrotropin-releasing hormone (TRH), and serum albumin levels between preschoolers with severe caries (SC) and measures taken for caries control.
    METHODS: A sample size of 300 children was selected but only 266 participated; 54.14% with SC and 45.86% caries-free. Blood samples for serum ferritin, hemoglobin, Vitamin D3, Ca++, TRH, and serum albumin levels were taken.
    RESULTS: The mean age was estimated to be 40.82 + 14.09 months. The serum ferritin level estimated mean value for sample pedodontic subjects came to be 29.58 ± 17.87 μg/L whereas their hemoglobin level with mean value 115.13 ± 10.12 g/L was measured. Logistic regression analysis (LRA) suggested that children with SC were nearly two times as likely to have ferritin level depreciation and likely six times more chance of FeDA (iron deficiency anemia) than in children with caries control. Children with SC had significantly lower mean Vitamin D3 value (p < 0.001), Ca++ (p < 0.001), and serum albumin (p < 0.001) levels, and significantly higher thyrotropin-releasing factor (p < 0.001) levels than those subjects without caries.
    CONCLUSIONS: Analysis of children with SC at a very young age significantly showed an increased chance of low ferritin levels than children with a caries-free mouth. The level of hemoglobin was deficient in children with SC at a very young age. Children with SC at a very young age appeared to be malnourished when compared with children without dental caries. Other contrasting parameters like FeDA, Vitamin D3, Ca++, and serum albumin concentrations were significantly deficient in children with SC at a very young age, in contrast, to a sample of children with a caries-free mouth. The analysis also suggested an increased level of TRH.
    CONCLUSIONS: The following research study sets a benchmark for the dental fraternity and other health specialists to analyze serum ferritin, hemoglobin, Vitamin D3, Ca++, TRH, and serum albumin levels while generally treating pediatric patients. Accordingly, supplements should be prescribed rationally even in dental caries.
    UNASSIGNED: Jha A, Jha S, Shree R, et al. Association between Serum Ferritin, Hemoglobin, Vitamin D3, Serum Albumin, Calcium, Thyrotropin-releasing Hormone with Early Childhood Caries: A Case-Control Study. Int J Clin Pediatr Dent 2021;14(5):648-651.
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  • 文章类型: Case Reports
    由有缺陷的宠物食品配方引起的胆钙化醇(维生素D3)毒性在猫中很少发生。然而,它会带来健康风险,即使受影响的宠物食品不是唯一的饮食。过量摄入维生素D3可能会导致高钙血症和软组织矿化,这些发现促使临床医生进一步探讨可行的病因。本案例系列描述了五只幼猫摄入极高的维生素D3的影响,这是由于食用鱼类补充小猫宠物食品(KPF)而引起的,该食品作为所有猫的饮食的一部分(案例1、2和3)或专门食用(案例4和5)。由于维生素D3的消耗量不同,诊断性检查显示高钙血症和氮质血症的严重程度不同,在进行诊断性影像学检查的病例中也有不同的影像学表现(病例2,4和5).通过取出受影响的食物并提供高钙血症的医疗管理来治疗所有猫。所有的猫都康复了,除了两只持续性的氮血症猫,发展为慢性肾病。这个案例系列的目标是,因此,描述急性维生素D3毒性的发生和解决,这是由于在家猫中描述过的饮食维生素D3摄入量最高。
    Cholecalciferol (vitamin D3) toxicity caused by defective pet food formulations is a rare occurrence described in cats. Nevertheless, it poses a health risk, even though the affected pet food is not fed as the sole diet. Excessive vitamin D3 intake might cause hypercalcemia and soft tissue mineralization, which are findings that prompt clinicians to further investigate the feasible etiology. This case series describes the effects of an extremely high vitamin D3 intake in five young cats caused by the consumption of a fish-based complementary kitten pet food (KPF) that was fed to all of the cats as part of their diet (cases 1, 2, and 3) or eaten exclusively (cases 4 and 5). Due to the different amounts of vitamin D3 consumed, diagnostic examinations showed different degrees of severity of hypercalcemia and azotemia as well as different radiographic findings in cases where diagnostic imaging was performed (cases 2, 4, and 5). All of the cats were treated by withdrawing the affected food and providing medical management of the hypercalcemia. All of the cats recovered, except for two persistent azotemic cats, which developed chronic kidney disease. The goal of this case series is, therefore, to describe the occurrence and resolution of an acute vitamin D3 toxicity due to the highest amount of dietary vitamin D3 intake that has ever been described in domestic cats.
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  • 文章类型: Journal Article
    维生素D缺乏被认为是一个新兴的健康问题,影响全球至少10亿患者。骨化三醇1,25(OH)2D3具有多种全身效应,包括消炎药,抗血栓和抗动脉粥样硬化的影响,解释其心脏保护作用。维生素D及其代谢物与补充剂在急性冠脉综合征(ACS)中的价值之间的精确关联仍然存在争议。本研究旨在寻找接受冠状动脉造影的患者中维生素D2,D3和代谢物与ACS之间的关联。
    这是一项病例对照研究,对2019年6月至2019年7月期间接受冠状动脉造影的73例连续成年ACS患者进行了比较,与50例无冠状动脉疾病且年龄和性别相匹配的对照组进行了比较。所有病例均行超声心动图和冠状动脉造影。所有参与者在入院时测量血浆维生素D及其代谢物以及化学概况。
    ACS患者的维生素D及其代谢物在统计学上明显低于对照组。多因素回归分析显示,25-羟维生素D(25(OH)D)和1,25-二羟维生素D(1,25(OH)2D)水平低可显著预测ACS的发生;其他显著预测因素为高收缩压(BP),高总胆固醇,和低高密度脂蛋白胆固醇。有趣的是,维生素D2和D3对ACS无显著预测作用(p>0.05).我们没有发现受影响的冠状血管的数量和维生素D代谢物之间有统计学意义的关联。此外,维生素D及其代谢物与超声心动图测得的左心室射血分数之间无统计学意义的相关性。
    维生素D及其所有代谢物与ACS有很强的关联。重要的是,低25(OH)D和1,25(OH)2D预测ACS,但维生素D2和D3没有。需要大型随机对照试验来验证补充维生素D对ACS患者的有益价值。
    UNASSIGNED: Vitamin D deficiency is considered an emerging health problem that affects at least one billion patients worldwide. Calcitriol 1,25(OH)2D3 has several systemic effects, including anti-inflammatory, anti-thrombotic and anti-atherosclerotic impacts that explain its cardioprotective effects. The precise association between vitamin D and its metabolites and the value of supplements in acute coronary syndrome (ACS) is still controversial. This study aims to search the association between vitamin D2, D3, and metabolites and ACS in patients undergoing coronary angiography.
    UNASSIGNED: This was a case-control study on 73 consecutive adult patients with ACS undergoing coronary angiography compared to 50 controls without coronary artery disease and matched for age and sex from June 2019 till July 2019. Echocardiography and coronary angiography were done for all cases. Plasma vitamin D and its metabolites were measured at admission for all participants along with chemistry profiles.
    UNASSIGNED: Vitamin D and its metabolites were statistically significantly lower in ACS patients than the controls. Multivariate regression analysis revealed that low levels of 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) significantly predicted ACS occurrence; the other significant predictors were high systolic blood pressure (BP), high total cholesterol, and low high-density lipoprotein-cholesterol. Interestingly, vitamin D2 and D3 did not significantly predict ACS (p>0.05). We did not find a statistically significant association between the number of affected coronary vessels and vitamin D metabolites. Moreover, there was no statistically significant correlation between vitamin D and its metabolites and left ventricular ejection fraction measured by echocardiography.
    UNASSIGNED: There was a strong association between vitamin D and all its metabolites with ACS. Significantly, low 25(OH)D and 1,25(OH)2D predicted ACS, but vitamin D2 and D3 did not. Large randomized controlled trials are needed to verify the beneficial values of vitamin D supplementation in ACS patients.
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  • 文章类型: Journal Article
    维生素D3和E的概述表明,微量营养素缺乏有助于2型糖尿病(T2DM)。进行了病例对照研究,以确定糖尿病马来西亚人血浆维生素D3和E异构体的状况。招募两组参与,一个包括50名糖尿病受试者(DM),一个包括50名非糖尿病(非DM)受试者,为了评估他们的血浆维生素D3,钙和维生素E状态。血糖状态(血红蛋白A1c,HbA1c;空腹血糖,FBG;C-肽)和血脂谱(总胆固醇,TC;甘油三酯,TG;低密度脂蛋白胆固醇,LDL-C;高密度脂蛋白胆固醇,HDL-C)进行了评估,其次是人体测量。Mann-WhitneyU检验,Kruskal-Wallis和Spearman的相关系数用于阐明血浆维生素D3和E水平与T2DM之间的关系。维生素D3缺乏组(<20ng/mL)与血糖状态(HbA1c和FBG)和血脂(HDL-C,LDL和TC)。Spearman的相关性表明,维生素D3状态与HDL水平密切相关(p<0.05)。同样,血浆总维生素E水平>4.9μg/mL显示FBG显著不同,HbA1c,C-肽,LDL,两组的HDL和TC水平。此外,家族史,吸烟,腰围和HbA1c水平与维生素D和E水平显著相关(p<0.05),但与FBG和血脂水平无关.这可能是因为非DM组的糖尿病前期状态影响了本研究的结果。
    An overview of vitamins D3 and E suggests micronutrient deficiency contributes to type 2 diabetes mellitus (T2DM). A case-control study was conducted to determine the status of plasma vitamins D3 and E isomers amongst diabetic Malaysians. Two groups were recruited for participation, one comprising fifty diabetic subjects (DM) and one comprising fifty non-diabetic (non-DM) subjects, in order to assess their plasma vitamin D3, calcium and vitamin E status. Glycaemic status (haemoglobin A1c, HbA1c; fasting blood glucose, FBG; C-Peptide) and lipid profiles (total cholesterol, TC; triglycerides, TG; low-density lipoprotein-cholesterol, LDL-C; high-density lipoprotein-cholesterol, HDL-C) were assessed, followed by anthropometric measurements. The Mann-Whitney U-test, Kruskal-Wallis and Spearman\'s correlation coefficient were used to elucidate the association between levels of plasma vitamins D3 and E and T2DM. The vitamin D3 deficiency group (<20 ng/mL) showed a significant correlation (p < 0.05) with glycaemic status (HbA1c and FBG) and lipid profiles (HDL-C, LDL and TC). Spearman\'s correlation demonstrated that vitamin D3 status is strongly correlated with HDL levels (p < 0.05). Similarly, plasma total vitamin E levels >4.9 μg/mL revealed significantly different FBG, HbA1c, C-Peptide, LDL, HDL and TC levels across both groups. Moreover, family history, smoking, waist circumference and HbA1c levels demonstrated a significant association (p < 0.05) with levels of vitamins D and E but not FBG and lipid profiles. This could be because the pre-diabetic status among the non-DM group influenced the outcomes of this study.
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