维生素D3是一种类固醇,广谱免疫调节,抗氧化剂,和抗炎激素在紫外线B(UVB)射线存在下通过内部皮下途径或通过补充剂形式的外部途径产生。维生素D3缺乏是危重患者中常见且可逆的死亡率和发病率的原因。包括2019年冠状病毒病(COVID-19)和其他病毒感染。维生素D3的主要功能是抑制促炎途径,包括核因子κB(NF-kB),炎性细胞因子,如白细胞介素-6(ILs-6),白细胞介素-18(ILs-18),和肿瘤坏死因子(TNF),预防COVID-19的神经感觉丧失,维持呼吸稳态,作为抗病毒药物,抗疟药,和抗高血压药。维生素D3在逆转先前患有神经系统疾病的患者的COVID-19感染方面具有重要作用,如老年痴呆症,帕金森病,运动神经元病,多发性硬化症,克雅氏病,中风,心血管问题,头痛,睡眠相关障碍,和其他人。此外,维生素D3在调节不同促炎细胞因子的基因表达中起关键作用。除了上面提供的信息,本评论文章提供了维生素D对抗COVID-19并发神经系统疾病的最新信息。此外,我们介绍了维生素D3的最新进展和分子作用机制。糖尿病,心血管疾病,神经系统疾病是合并症,在这些情况下,维生素D3是COVID-19感染的关键调节剂。在COVID-19流行期间,诸如性别等因素,纬度,营养,人口统计学,污染,和肠道微生物群需要对维生素D补充剂进行更多研究。
Vitamin D3 is a secosteroid, broad-spectrum immunomodulatory, antioxidant, and anti-inflammatory hormone produced either by the internal subcutaneous pathway in the presence of ultraviolet B (UVB) rays or by the external pathway in the form of supplements. Vitamin D3 deficiency is a common and reversible contributor to mortality and morbidity among critically ill patients, including Coronavirus Disease 2019 (COVID-19) and other viral infections. The major functions of vitamin D3 are inhibiting the proinflammatory pathways, including nuclear factor kappa B (NF-kB), inflammatory cytokines, such as interleukin-6 (ILs-6), interleukin-18 (ILs-18), and tumour necrosis factor (TNF), preventing the loss of neural sensation in COVID-19, maintaining respiratory homeostasis, and acting as an antiviral, antimalarial, and antihypertensive agent. Vitamin D3 has an important role in reversing the COVID-19 infection in patients who have previously suffered from a neurological disease, such as Alzheimer\'s disease, Parkinson disease, motor neuron disease, multiple sclerosis, Creutzfeldt-Jakob disease, stroke, cardiovascular problems, headache, sleep-associated disorder, and others. Moreover, vitamin D3 plays a key role in regulating the gene expression of different pro-inflammatory cytokines. In addition to the information provided above, the current
review article provides the most recent information on Vitamin D against COVID-19 with comorbid neurological disorders. Furthermore, we present the most recent advancement and molecular mechanism of action of vitamin D3. Diabetes, cardiovascular disease, and neurological disorders are comorbid conditions, and vitamin D3 is a critical regulator of COVID-19 infection during these conditions. In the midst of the COVID-19 epidemic, factors such as sex, latitudes, nutrition, demography, pollution, and gut microbiota warrants for additional research on vitamin D supplements.