背景:COVID-19疫苗接种对于在全球范围内减轻疾病负担至关重要。这一战略的成功将在很大程度上取决于疫苗的接收程度。以前的评论产生了矛盾的结果,也没有雨伞审查。因此,本综述的目的是将关于COVID-19疫苗全球接受率及其影响因素的相互矛盾的数据结合起来.
方法:使用PRISMA指南,PubMed,Embase,Scopus,WebofSciences,Cochrane系统评价数据库,搜索了Scopus和GoogleScholar报告的COVID-19疫苗接受度和/或其决定因素。纳入研究的质量采用多重系统评价(AMSTAR)进行评估。应用加权逆方差随机效应模型来找到合并估计。亚组分析,异质性,还评估了发表偏倚和敏感性分析.
结果:包括22名SRM和10,433,306名研究参与者。全球合并的COVID-19疫苗接受率为60.23(95%CI:58.27,62.18)。在低收入国家,在全球范围内的研究中,COVID-19疫苗接受的汇总水平为54.07(50.31,57.83),而这一幅度为64.32(62.24,66.40)。较高的教育水平(AOR=1.96;95%CI:1.20,2.73),良好的知识水平(2.20;95%CI:1.36,3.03),态度良好(AOR=4.50;95%CI:2.89,6.12),既往有COVID-19感染史(AOR=3.41;95%CI:1.77,5.06),男性(AOR=1.62;95%CI:1.47,1.77),和慢性病(AOR=1.54;95%CI:1.18,1.90)是COVID-19疫苗接受度的预测因素。
结论:COVID-19疫苗接受度的汇总水平差异很大,特别是在低收入国家,低得令人无法接受。更高的教育水平,良好的知识水平,积极的态度,以前的COVID-19病史,男性,慢性疾病是COVID-19疫苗接受率的影响因素。决策者等利益相关者的共同努力,需要疫苗运动计划规划者来提高COVID-19疫苗的接受率。
The COVID-19 vaccination is essential for reducing disease burden on a worldwide scale. The success of this strategy will largely depend on how well vaccines are received. Previous reviews had produced contradictory results, and there had been no umbrella
review. Therefore, the objective of this umbrella
review was to combine the contradictory data regarding the COVID-19 vaccination\'s global acceptance rate and its contributing factors.
Using PRISMA guideline, PubMed, Embase, Scopus, Web of Sciences, Cochrane Database of Systematic Reviews, Scopus and Google Scholar which reported COVID-19 vaccine acceptance and/or its determinants were searched. The quality of the included studies was assessed using Assessment of Multiple Systematic Reviews (AMSTAR). A weighted inverse variance random-effects model was applied to find the pooled estimates. The subgroup analysis, heterogeneity, publication bias and sensitivity analysis were also assessed.
Twenty-two SRM with 10,433,306 study participants were included. The pooled COVID-19 vaccine acceptance rate globally is found to be 60.23 (95% CI: 58.27, 62.18). In low-income countries, the pooled level of COVID-19 vaccine acceptance was found to be 54.07(50.31, 57.83) while this magnitude is 64.32 (62.24,66.40) among studies across the globe. Higher level of education (AOR =1.96; 95% CI:1.20, 2.73), good level of knowledge (2.20; 95% CI:1.36, 3.03), favourable attitude (AOR =4.50; 95% CI:2.89, 6.12), previous history of COVID-19 infection (AOR =3.41; 95% CI:1.77, 5.06), male sex (AOR =1.62; 95% CI:1.47, 1.77), and chronic disease (AOR =1.54; 95% CI:1.18, 1.90) were predictors of COVID-19 vaccine acceptance.
The pooled level of COVID-19 vaccine acceptance highly varied and found to be unacceptably low particularly in low-income countries. Higher level of education, good level of knowledge, favourable attitude, previous history of COVID-19, male sex, and chronic disease were factors of COVID-19 vaccine acceptance rate. A collaborative effort of stakeholders such as policymakers, and vaccine campaign program planners is needed to improve the acceptance rate of COVID-19 vaccine.