DTaP-HBV-IPV-Hib六价疫苗已在高收入国家使用多年来预防白喉,破伤风,百日咳,乙型肝炎,脊髓灰质炎,和侵袭性b型流感嗜血杆菌病。目前,中国尚未批准使用六价疫苗。父母对六价疫苗的接受和兴趣的证据可以帮助政策制定者和制造商做出进入中国疫苗市场和免疫计划的决定。我们测量了父母对六价疫苗的接受度和支付意愿(WTP),以提供此类证据。我们对中国7个城市的16家疫苗接种诊所的儿童照顾者进行了横断面调查,并获得了社会人口统计信息,疾病知识,对疫苗的信心,以前的疫苗接种经验,以及六价疫苗的接受和WTP。多因素logistic回归用于确定影响接受度的因素,多变量tobit回归用于确定影响WTP的因素。2023年4月28日至6月30日,共有581名0-6岁儿童家长参与调查;435名(74.87%,95%CI:71.3%-78.4%)父母表示接受六价疫苗。居住地点,父母的教育水平,接种疫苗付费的经验,疾病知识得分是影响父母选择接种疫苗的关键因素。平均(SD)和中位数(IQR)愿意支付完整的4剂疗程疫苗接种分别为2266.66(1177.1)CNY和2400(1600-2800)CNY。儿童年龄(p<.001),父母的教育水平(p=.024),感知价格障碍(p<.001)与WTP显著相关。父母对六价疫苗的接受度和支付意愿很高。父母自掏腰包的钱越少,他们就越愿意接受疫苗。因此,如果疫苗由医疗保险覆盖,接受度可能会进一步增加,由政府免费提供,或者它的价格降低了。本研究结果为我国优化和调整免疫策略提供了参考。
DTaP-HBV-IPV-Hib hexavalent vaccine has been used in high-income countries for many years to prevent diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive Haemophilus influenzae type b disease. Currently, no hexavalent vaccines have been approved for use in
China. Evidence of parental acceptance and interest in hexavalent vaccines can help policy makers and manufacturers make decisions about entering the vaccine market and the immunization program in
China. We measured parental acceptance and willingness-to-pay (WTP) for a hexavalent vaccine to provide such evidence. We conducted a cross-sectional survey of children\'s caregivers in 16 vaccination clinics in seven cities in
China and obtained information on socio-demographics, knowledge of disease, confidence in vaccines, previous vaccination experience, and acceptance of and WTP for hexavalent vaccine. Multivariate logistic regression was used to determine factors influencing acceptance, and multivariate tobit regression was used to identify factors impacting WTP. Between April 28 and June 30, 2023, a total of 581 parents of children aged 0-6 years participated in the survey; 435 (74.87%, 95% CI:71.3%-78.4%) parents indicated acceptance of hexavalent vaccine. Residence location, parents\' education level, experience paying for vaccination, and disease knowledge scores were key factors affecting parents\' choices for vaccination. Mean (SD) and median (IQR) willingness to pay for full 4-dose course vaccination were 2266.66 (1177.1) CNY and 2400 (1600-2800) CNY. Children\'s age (p < .001), parents\' education level (p = .024), and perceived price barriers (p < .001) were significantly associated with WTP. Parents have high acceptance and willingness to pay for hexavalent vaccine. The less money parents have to pay out of pocket, the more willing they can be to accept the vaccine. Therefore, acceptance may increase even further if the vaccine is covered by medical insurance, provided free of charge by the government, or if its price is reduced. Our results provide reference for optimizing and adjusting immunization strategies in
China.