未经证实:旨在调查非重症监护(IC)COVID-19单位中2019年冠状病毒病(COVID-19)患者有无谵妄的生化特征差异。
UNASSIGNED:本研究设计为观察,单中心,病例对照研究,包括43例精神错乱患者和45例非ICCOVID-19单位住院非精神错乱患者。根据DSM-5谵妄诊断标准,由精神科顾问诊断谵妄。入院时的实验室检查等独立变量,临床特征,患者特征由研究人员从电子病历中获得。在初步分析中,二项logistic回归模型用于调查谵妄的相关因素,它被确定为结果变量。然后根据潜在的混杂因素调整多变量逻辑模型,包括年龄,性别,神经认知障碍病史和Charlson合并症指数(CCI)。
未经评估:我们观察到尿素含量较高,D-二聚体,肌钙蛋白T,前B型利钠肽,与无谵妄患者相比,谵妄患者的CCI。我们还观察到较低水平的估计肾小球滤过率(eGFR),血清白蛋白,和O2饱和度以及住院时间的减少。在调整了性别等混杂因素后,年龄,和合并症,我们发现尿素(调整后的估计值=0.015;95%置信区间[CI]=0.058-0.032,P=0.039),尿素/肌酐比值(调整估计值=0.008;95%CI=0.002-0.013,P=0.011),和肌钙蛋白T(校正估计值=0.066;95%CI=0.014-0.118,P=0.014)是与谵妄相关的独立生物标志物。
未经证实:谵妄与COVID-19患者较高的尿素水平和尿素/肌酐比值相关。此外,肌钙蛋白T与谵妄之间的关系可能有助于理解COVID-19中脑与心脏之间的潜在联系。需要更多具有更大样本量的多中心研究来概括这些结果。
UNASSIGNED: To investigate the differences in biochemical characteristics between Coronavirus Disease 2019 (COVID-19) patients with and without delirium in non-intensive care (IC) COVID-19 units was aimed.
UNASSIGNED: This study was designed as an observational, single-centered, and
case-control study consisting of 43 delirious patients and matched 45 non-delirious patients admitted to non-IC COVID-19 units. Delirium was diagnosed by a consultant psychiatrist according to the DSM-5 delirium diagnostic criteria. Independent variables such as laboratory tests at the time of admission, clinical features, and patient characteristics were obtained from electronic medical records by researchers. In the primary analyses, binomial logistic regression models were used to investigate the factors associated with delirium, which was identified as the outcome variable. Multivariate logistic models were then adjusted for potential confounding factors, including age, gender, history of neurocognitive disorders and Charlson Comorbidity Index (CCI).
UNASSIGNED: We observed higher levels of urea, d-dimer, troponin-T, proB-type natriuretic peptide, and CCI in patients with delirium compared to patients without delirium. We also observed lower levels of estimated glomerular filtration rate (eGFR), serum albumin, and O2 saturation and a decrease in the length of stay at the hospital. After adjusting for confounding factors such as gender, age, and comorbidity, we found that urea (adjusted estimate=0.015; 95% Confidence Interval [CI]=0.058-0.032, P=0.039), urea/creatinine ratio (adjusted estimate=0.008; 95% CI=0.002-0.013, P=0.011), and troponin-T (adjusted estimate=0.066; 95% CI=0.014-0.118, P=0.014) were independent biomarkers associated with delirium.
UNASSIGNED: Delirium is associated with higher urea levels and urea/creatinine ratios in COVID-19 patients. In addition, the relationship between troponin-T and delirium may help understand the potential link between the brain and the heart in COVID-19. Additional multi-centred studies with larger sample sizes are needed to generalise these results.