PDF(Pubmed)
Abstract：
UNASSIGNED: Elevated troponin T (cTnT) and/or troponin I (cTnI) can be ascribed to multiple causes, mostly resulting from cardiac tissue damage and in lesser numbers resulting from non-cardiac related causes. The presence of macrotroponins is easily overlooked, with potentially negative consequences.
UNASSIGNED: This case report presents a case study of a 12-year-old child known to have MYH7 gene-associated hypertrophic cardiomyopathy with acute chest pain combined with an unexpected high cTnT and cTnI. A cardiac cause was deemed unlikely after additional investigation, as these showed no abnormalities. After consulting a laboratory specialist, it could be concluded that the high cTnT and cTnI were a result of macrotroponin complexes, a protein complex consisting of circulating protein and endogenous autoantibodies against that protein, resulting in elevated values with misguiding and uncertain clinical significance.
UNASSIGNED: Awareness of the existence of macrotroponins could have prevented costly diagnostics and prolonged hospital admission with grave psychological impact, especially in children.
UNASSIGNED: This case report presents a case study of a 12-year-old child known to have MYH7 gene-associated hypertrophic cardiomyopathy with acute chest pain combined with an unexpected high cTnT and cTnI. A cardiac cause was deemed unlikely after additional investigation, as these showed no abnormalities. After consulting a laboratory specialist, it could be concluded that the high cTnT and cTnI were a result of macrotroponin complexes, a protein complex consisting of circulating protein and endogenous autoantibodies against that protein, resulting in elevated values with misguiding and uncertain clinical significance.
UNASSIGNED: Awareness of the existence of macrotroponins could have prevented costly diagnostics and prolonged hospital admission with grave psychological impact, especially in children.
摘要：
■肌钙蛋白T（cTnT）和/或肌钙蛋白I（cTnI）升高可归因于多种原因，主要由心脏组织损伤引起，而较少由非心脏相关原因引起。大肌钙蛋白的存在很容易被忽视，潜在的负面后果。
■本病例报告提供了一个12岁儿童的案例研究，该儿童已知患有MYH7基因相关的肥厚型心肌病，伴有急性胸痛，并伴有意外的高cTnT和cTnI。经过额外的调查后认为心脏原因不太可能，因为这些没有异常。在咨询了实验室专家之后，可以得出结论，高cTnT和cTnI是大肌钙蛋白复合物的结果，由循环蛋白质和针对该蛋白质的内源性自身抗体组成的蛋白质复合物，导致值升高，具有误导和不确定的临床意义。
■意识到巨肌钙蛋白的存在可以阻止昂贵的诊断和长期住院，并产生严重的心理影响，尤其是儿童。
■本病例报告提供了一个12岁儿童的案例研究，该儿童已知患有MYH7基因相关的肥厚型心肌病，伴有急性胸痛，并伴有意外的高cTnT和cTnI。经过额外的调查后认为心脏原因不太可能，因为这些没有异常。在咨询了实验室专家之后，可以得出结论，高cTnT和cTnI是大肌钙蛋白复合物的结果，由循环蛋白质和针对该蛋白质的内源性自身抗体组成的蛋白质复合物，导致值升高，具有误导和不确定的临床意义。
■意识到巨肌钙蛋白的存在可以阻止昂贵的诊断和长期住院，并产生严重的心理影响，尤其是儿童。
