{Reference Type}: Case Reports
{Title}: Unexpected high troponin T and I values in a child with hypertrophic cardiomyopathy and acute chest pain: a case report.
{Author}: van Avezaath LK;Nijenhuis HP;Muller Kobold AC;
{Journal}: Eur Heart J Case Rep
{Volume}: 7
{Issue}: 8
{Year}: 2023 Aug
暂无{DOI}: 10.1093/ehjcr/ytad375
{Abstract}: <B>UNASSIGNED: </B>Elevated troponin T (cTnT) and/or troponin I (cTnI) can be ascribed to multiple causes, mostly resulting from cardiac tissue damage and in lesser numbers resulting from non-cardiac related causes. The presence of macrotroponins is easily overlooked, with potentially negative consequences.<BR><B>UNASSIGNED: </B>This case report presents a case study of a 12-year-old child known to have MYH7 gene-associated hypertrophic cardiomyopathy with acute chest pain combined with an unexpected high cTnT and cTnI. A cardiac cause was deemed unlikely after additional investigation, as these showed no abnormalities. After consulting a laboratory specialist, it could be concluded that the high cTnT and cTnI were a result of macrotroponin complexes, a protein complex consisting of circulating protein and endogenous autoantibodies against that protein, resulting in elevated values with misguiding and uncertain clinical significance.<BR><B>UNASSIGNED: </B>Awareness of the existence of macrotroponins could have prevented costly diagnostics and prolonged hospital admission with grave psychological impact, especially in children.