背景和目的:生物材料在牙科中的应用非常普遍。从商业角度来看,不同类型的骨传导和骨诱导生物材料可供临床医生使用。在骨传导材料领域,临床医生可以使用由异源骨骼制成的生物材料,包括牛的生物材料,猪,和马的起源,和天然来源的生物材料,如珊瑚和羟基磷灰石。近年来,使用数字信息合成nano-Ha和生产支架已经成为可能。尽管已经生产了各种各样的生物材料,没有科学证据证明它们在保留拔除后部位或执行引导骨再生方面是绝对不可或缺的。虽然没有科学证据表明一种材料比另一种材料更好,有证据表明,几种产品具有更好的原位持久性。本文介绍了评估组织学结果的初步研究,ISQ值,和纳米HA的流行。材料和方法:在这项研究中,我们计划使用一种基于纳米羟基磷灰石的新生物材料在一个提取后部位进行植入;这项研究中的纳米HA是NuvaBONE(Overmed,Buccinasco,米兰,意大利)。这是一种基于纳米结构仿生羟基磷灰石的合成骨移植替代品,用于口腔颌面外科,骨科,创伤学,脊柱手术,和神经外科。在我们的试点案例中,一个牙齿没有希望的病人接受了拔除,拔牙后剩余的大缺损用纳米HA填充以恢复体积。十二个月后,患者被预约进行植入手术以替换缺失的牙齿。在手术的时候,使用内侧4mm和8mm深的环钻对再生组织进行活检。结果:活检的组织学结果显示丰富的骨形成,从插入到假体阶段增加的ISQ值很高,吸收过程中羟基磷灰石颗粒的良好重组。植入物功能良好,更换的牙齿显示出良好的美学。结论:该试点病例的良好结果表明,与对照位点相比,开始下一个多中心研究以获得有关该纳米羟基磷灰石(NH)的更多更清晰的信息。
Background and Objectives: The use of biomaterials in dentistry is extremely common. From a commercial perspective, different types of osteoconductive and osteoinductive biomaterials are available to clinicians. In the field of osteoconductive materials, clinicians have biomaterials made of heterologous bones at their disposal, including biomaterials of bovine, porcine, and equine origins, and biomaterials of natural origin, such as corals and hydroxyapatites. In recent years, it has become possible to synthesize nano-Ha and produce scaffolds using digital information. Although a large variety of biomaterials has been produced, there is no scientific evidence that proves their absolute indispensability in terms of the preservation of postextraction sites or in the execution of guided bone regeneration. While there is no scientific evidence showing that one material is better than another, there is evidence suggesting that several products have better in situ permanence. This article describes a preliminary study to evaluate the histological results, ISQ values, and prevalence of nano-HA. Materials and Methods: In this study, we planned to use a new biomaterial based on nanohydroxyapatite for implantation at one postextraction site; the nano-HA in this study was NuvaBONE (Overmed, Buccinasco, Milano, Italy). This is a synthetic bone graft substitute that is based on nanostructured biomimetic hydroxyapatite for application in oral-maxillofacial surgery, orthopedics, traumatology, spine surgery, and neurosurgery. In our pilot
case, a patient with a hopeless tooth underwent extraction, and the large defect remaining after the removal of the tooth was filled with nano-HA to restore the volume. Twelve months later, the patient was booked for implant surgery to replace the missing tooth. At the time of the surgery, a biopsy of the regenerated tissue was taken using a trephine of 4 mm in the inner side and 8 mm deep. Results: The histological results of the biopsy showed abundant bone formation, high values of ISQ increasing from the insertion to the prosthetic phase, and a good reorganization of hydroxyapatite granules during resorption. The implant is in good function, and the replaced tooth shows good esthetics. Conclusions: The good results of this pilot
case indicate starting the next Multicentric study to have more and clearer information about this nanohydroxyapatite (NH) compared with control sites.