Abstract：
Cases of relatively safe dental implant treatment in patients with low-volume bisphosphonate (BP) have been gradually reported. Although bone augmentation is commonly used when the bone volume is insufficient for implant placement, the studies and case reports regarding the safety of bone augmentation in patients treated with BP remain insufficient. Herein, we report a case wherein bone augmentation was performed after BP treatment with bone healing realized according to imaging, and we review the literature regarding BP and bone augmentation. A 67-year-old Japanese woman requested implant treatment for a hopeless lower right second molar. She had been taking minodronic acid hydrate (50 mg/4 wk) for 18 months to treat steroid-induced osteoporosis. After obtaining informed consent, tooth extraction and bone augmentation within the extraction socket were performed. The tooth was extracted atraumatically to preserve the surrounding alveolar bone, and the extraction socket was intensely curetted. Subsequently, the socket was filled with carbonate apatite granules and covered with a biodegradable membrane, and the wound was sutured without tension. Although protracted wound healing without any symptoms of infection was observed, the wound healed completely. No clinical symptoms were observed, the color of the mucosa at the site was healthy, and imaging findings at 6 months postoperation indicated that osteogenesis had progressed uneventfully.
摘要：
在低容量双膦酸盐（BP）患者中相对安全的种植牙治疗病例已逐渐被报道。尽管通常在骨体积不足以放置植入物时使用骨增强术，关于BP治疗患者的骨强化安全性的研究和病例报告仍然不足.在这里，我们报告了一例在BP治疗后进行骨增强的病例，根据成像实现骨骼愈合，我们回顾了有关血压和骨扩张的文献。一名67岁的日本妇女要求对无望的右下第二磨牙进行植入治疗。她已经服用米诺膦酸水合物（50mg/4wk）18个月来治疗类固醇引起的骨质疏松症。在获得知情同意后，在拔牙槽内进行拔牙和骨增强。无损伤地拔出牙齿以保留周围的牙槽骨，拔牙窝被强烈刮伤。随后，插座充满碳酸盐磷灰石颗粒，并覆盖有可生物降解的膜，伤口缝合时没有张力。尽管观察到伤口愈合时间延长，但没有任何感染症状，伤口完全愈合了。未观察到临床症状，该部位粘膜的颜色是健康的，术后6个月的影像学发现表明成骨进展顺利。
