背景:Swertiachirayita(Roxb。)H.岩溶。是传统上使用的,龙胆科公认的药用植物,具有显着的治疗潜力。传统上,它被用来治疗各种疾病,如发烧,呕吐,黄疸,消化系统疾病,心脏病,糖尿病,疟疾,蝎子咬伤,和皮肤病。
目的:本综述强调了传统用途,植物化学,药理学,毒理学,化学剖析,并通过分析和光谱技术对分离的化合物进行结构鉴定。这篇综述证明了先进的民族药理学研究的可能性。
方法:关于S.chirayita的文献是从WebofScience等书目数据库中获得的,PubMed,科学直接,美国化学学会(ACS)谷歌学者,SciFinder编制的审查将覆盖到2022年3月。
结果:大约,123种特殊的代谢产物,包括黄原酮,seco-ippoids,萜类化合物,生物碱,和黄酮类化合物已从S.chirayita分离和表征。提取物和分离的化合物表现出广泛的药理作用,如抗炎,抗氧化剂,抗肿瘤,保肝,抗病毒,抗疟药,和抗菌为这种药用植物的传统主张提供科学证据。此外,使用HPTLC的各种分析方法,UPLC,HPLC,LC-MS,和GC-MS也已被证明可以确定S.chirayita的植物化学物质。
结论:当前文章提供了有关传统用法的信息,植物化学,化学剖析,结构阐明,药理功效,毒性,以及S.chirayita的未来前景。这种植物长期以来一直被土著人民以各种方式使用。S.chirayita已经报道了许多植物成分和几种药理活性。然而,仍然存在一些科学空白,例如生物活性化合物的鉴定,分离的生物活性化合物的构效关系和机制作用,开发有效的全面质量控制分析方法,和需要解决的安全概况。
BACKGROUND: Swertia chirayita (Roxb.) H. Karst. is a traditionally used, well-recognized medicinal plant of the family Gentianaceae with significant therapeutic potential. It has been traditionally used to cure various ailments such as fever, vomiting, jaundice, digestive disorders, heart diseases, diabetes, malaria, scorpion bite, and skin diseases.
OBJECTIVE: The present
review emphasized the traditional uses, phytochemistry, pharmacology, toxicology, chemical profiling, and structural identification of isolated compounds by analytical and spectroscopic techniques. This
review demonstrates the possibility of advanced ethnopharmacological research.
METHODS: The literature on S. chirayita was obtained from bibliographic databases like Web of Science, PubMed, Science-Direct, American Chemical Society (ACS), Google Scholar, and SciFinder. The compiled
review is covered up until March 2022.
RESULTS: Approximately, 123 specialized metabolites including xanthones, seco-iridoids, terpenoids, alkaloids, and flavonoids have been isolated and characterized from S. chirayita. The extract and isolated compounds exhibited a wide spectrum of pharmacological effects such as anti-inflammatory, antioxidant, antitumor, hepatoprotective, antiviral, antimalarial, and antibacterial offering scientific evidence for traditional claims of this medicinal plant. In addition, various analytical methods using HPTLC, UPLC, HPLC, LC-MS, and GC-MS have also been documented to determine the phytochemicals of S. chirayita.
CONCLUSIONS: The current article provides information on traditional usage, phytochemistry, chemical profiling, structure elucidation, pharmacological efficacy, toxicity, and future prospects of S. chirayita. This plant has long been traditionally used in a variety of ways by indigenous people. Numerous phytoconstituents and several pharmacological activities have been reported in S. chirayita. However, there are still some scientific gaps such as identification of bioactive compounds, structure-activity relationship and mechanistic action of isolated bioactive compounds, development of effective analytical methods for comprehensive quality control, and safety profiles that need to be addressed.