背景:爬楼梯是一种容易获得的身体活动形式,具有潜在的心脏保护作用。在这里,我们在日本人群中调查了爬楼梯与动脉粥样硬化性心血管疾病(ASCVD)发病率之间的关系.
方法:这项前瞻性队列研究使用了来自7282名参与者的数据,30-84岁,在Suita研究中注册,没有中风和缺血性心脏病(IHD)。标准方法用于检测事件ASCVD事件,包括脑梗塞和IHD,在后续行动中。使用基线问卷评估爬楼梯。我们应用Cox回归计算20-39%爬楼梯的事件ASCVD的风险比(HR)和95%置信区间(95%CIs),40-59%,与<20%的时间相比,≥60%。我们调整了年龄的回归模型,性别,身体质量指数,吸烟,酒精消费,身体活动,高血压,糖尿病,心房颤动,血脂谱,慢性肾病,心脏杂音或瓣膜疾病史。
结果:在16.6年的中位随访期内共检测到536起新的ASCVD事件。在年龄和性别调整模型中,爬楼梯20-39%,40-59%,≥60%的时间与较低的ASCVD发生率相关:HR(95%CIs)=0.72(0.56,0.92),0.86(0.68,1.08),和0.78(0.61,0.99),分别(p趋势=0.020)。调整生活方式和临床因素后,相应的关联减弱:HR(95%CIs)=0.74(0.58,0.95),0.90(0.71,1.13),和0.89(0.69,1.13),分别(p趋势=0.152)。
结论:频繁爬楼梯与较低的ASCVD发病率相关;然而,参与者的生活方式和临床因素部分解释了这种关联.
BACKGROUND: Stair climbing is a readily available form of physical activity with potential cardioprotective merits. Herein, we investigated the association between stair climbing and atherosclerotic cardiovascular disease (ASCVD) incidence among Japanese people.
METHODS: This prospective cohort
study used data from 7,282 participants, aged 30-84 years, registered in the Suita
Study and free from stroke and ischemic heart disease (IHD). Standard approaches were used to detect incident ASCVD events, including cerebral infarction and IHD, during follow-up. Stair climbing was assessed using a baseline questionnaire. We applied the Cox regression to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of incident ASCVD for climbing stairs in 20-39%, 40-59%, and ≥60% compared to <20% of the time. We adjusted the regression models for age, sex, body mass index, smoking, alcohol consumption, physical activity, hypertension, diabetes, atrial fibrillation, lipid profile, chronic kidney disease, and history of cardiac murmur or valvular diseases.
RESULTS: A total of 536 new ASCVD events were detected within a median follow-up period of 16.6 years. In the age- and sex-adjusted model, stair climbing 20-39%, 40-59%, and ≥60% of the time was associated with lower ASCVD incidence: HRs (95% CIs) = 0.72 (0.56, 0.92), 0.86 (0.68, 1.08), and 0.78 (0.61, 0.99), respectively (p-trend = 0.020). The corresponding associations were attenuated after adjusting for lifestyle and clinical factors: HRs (95% CIs) = 0.74 (0.58, 0.95), 0.90 (0.71, 1.13), and 0.89 (0.69, 1.13), respectively (p-trend = 0.152).
CONCLUSIONS: Frequent stair climbing was associated with lower ASCVD incidence; however, this association was partly explained by lifestyle and clinical factors of participants.