背景:在过去的三十年里,我们对女性睡眠呼吸暂停的认识有了进步,揭示病理生理学的差异,诊断,与男性相比,治疗。然而,迄今为止,还没有一项现实生活中的研究在长期CPAP的背景下探讨了面罩相关副作用(MRSEs)与性别之间的关系.
方法:InterfaceVent-CPAP研究是一项前瞻性的现实生活中的横断面研究,在接受至少3个月CPAP的呼吸暂停成人队列中进行(34种不同的口罩,没有性别特定的面膜系列)。患者使用视觉模拟量表(VAS)评估MRSE。CPAP非依从性定义为每天平均CPAP使用少于4小时。这项辅助研究的主要目的是调查性别对患者报告的MRSE患病率的影响。次要分析根据性别评估MRSE对CPAP使用和CPAP不依从性的影响。
结果:共有1484名患者接受治疗,中位治疗时间为4.4年(IQ25-75:2.0-9.7),女性占27.8%。患者报告的口罩损伤的患病率,定义为VAS评分≥5(p=0.021),女性高于男性(9.6%对5.3%)。对于鼻枕面罩,女性口干MRSEVAS评分中位数较高(p=0.039).对于口鼻口罩,男性流鼻涕的MRSEVAS评分中位数较高(p=0.039).多元回归分析显示,无论男女,口干与CPAP的使用呈独立负相关,与CPAP非依从性呈正相关。
结论:在现实生活中接受长期CPAP治疗的患者中,患者报告的MRSE存在性别差异.在个性化医疗的背景下,这些结果表明,如果开发出专门针对女性的口罩,未来口罩的设计应该考虑这些性别差异。然而,只有口干,与面膜设计无关的副作用,影响CPAP的使用和不遵守。
背景:界面事件登记为临床医师。GOV(NCT03013283)。第一次登记日期是2016-12-23。
BACKGROUND: Over the past three decades, our understanding of sleep apnea in women has advanced, revealing disparities in pathophysiology, diagnosis, and treatment compared to men. However, no real-life
study to date has explored the relationship between mask-related side effects (MRSEs) and gender in the context of long-term CPAP.
METHODS: The InterfaceVent-CPAP
study is a prospective real-life cross-sectional
study conducted in an apneic adult cohort undergoing at least 3 months of CPAP with unrestricted mask-access (34 different masks, no gender specific mask series). MRSE were assessed by the patient using visual analog scales (VAS). CPAP-non-adherence was defined as a mean CPAP-usage of less than 4 h per day. The primary objective of this ancillary
study was to investigate the impact of gender on the prevalence of MRSEs reported by the patient. Secondary analyses assessed the impact of MRSEs on CPAP-usage and CPAP-non-adherence depending on the gender.
RESULTS: A total of 1484 patients treated for a median duration of 4.4 years (IQ25-75: 2.0-9.7) were included in the cohort, with women accounting for 27.8%. The prevalence of patient-reported mask injury, defined as a VAS score ≥ 5 (p = 0.021), was higher in women than in men (9.6% versus 5.3%). For nasal pillow masks, the median MRSE VAS score for dry mouth was higher in women (p = 0.039). For oronasal masks, the median MRSE VAS score for runny nose was higher in men (p = 0.039). Multivariable regression analyses revealed that, for both women and men, dry mouth was independently and negatively associated with CPAP-usage, and positively associated with CPAP-non-adherence.
CONCLUSIONS: In real-life patients treated with long-term CPAP, there are gender differences in patient reported MRSEs. In the context of personalized medicine, these results suggest that the design of future masks should consider these gender differences if masks specifically for women are developed. However, only dry mouth, a side effect not related to mask design, impacts CPAP-usage and non-adherence.
BACKGROUND: INTERFACEVENT IS REGISTERED WITH CLINICALTRIALS.GOV (NCT03013283).FIRST REGISTRATION DATE IS 2016-12-23.