Abstract：
BACKGROUND: Sleep Disordered Breathing (SDB) has been shown to increase the risk of stroke and despite recommendations, routine evaluation for SDB in acute stroke is not consistent across institutions. The necessary logistics and expertise required to conduct sleep studies in hospitalized patients remain a significant barrier. This study aims to evaluate the feasibility of high-resolution pulse-oximetry (HRPO) for the screening of SDB in acute stroke. Secondarily, considering impact of SDB on acute stroke, we investigated whether SDB at acute stroke predicts functional outcome at discharge and at 3 months post-stroke.
METHODS: Patients with acute mild to moderate ischemic stroke underwent an overnight HRPO within 48 h of admission. Patients were divided into SDB and no-SDB groups based on oxygen desaturations index(ODI > 10/h). Stepwise multivariate logistic regression analysis was applied to identify the relevant predictors of functional outcome (favorable [mRS 1-2 points] versus unfavorable [mrS > = 3 points]).
RESULTS: Of the 142 consecutively screened patients, 96 were included in the analysis. Of these, 33/96 (34%) were identified as having SDB and were more likely to have unfavorable mRS scores as compared to those without SDB (odds ratio = 2.70, p-value = 0.032).
CONCLUSIONS: HRPO may be a low-cost and easily administered screening method to detect SDB among patients hospitalized for acute ischemic stroke. Patients with SDB (as defined by ODI) have a higher burden of neurological deficits as compared to those without SDB during hospitalization.
METHODS: Patients with acute mild to moderate ischemic stroke underwent an overnight HRPO within 48 h of admission. Patients were divided into SDB and no-SDB groups based on oxygen desaturations index(ODI > 10/h). Stepwise multivariate logistic regression analysis was applied to identify the relevant predictors of functional outcome (favorable [mRS 1-2 points] versus unfavorable [mrS > = 3 points]).
RESULTS: Of the 142 consecutively screened patients, 96 were included in the analysis. Of these, 33/96 (34%) were identified as having SDB and were more likely to have unfavorable mRS scores as compared to those without SDB (odds ratio = 2.70, p-value = 0.032).
CONCLUSIONS: HRPO may be a low-cost and easily administered screening method to detect SDB among patients hospitalized for acute ischemic stroke. Patients with SDB (as defined by ODI) have a higher burden of neurological deficits as compared to those without SDB during hospitalization.
摘要：
背景：睡眠呼吸障碍（SDB）已被证明会增加中风的风险，尽管有建议，SDB在急性卒中中的常规评估在各机构之间并不一致.在住院患者中进行睡眠研究所需的必要后勤和专业知识仍然是一个重大障碍。本研究旨在评估高分辨率脉搏血氧饱和度（HRPO）在急性中风中筛查SDB的可行性。其次，考虑到SDB对急性中风的影响，我们调查了急性卒中时SDB是否可预测出院时和卒中后3个月时的功能结局.
方法：急性轻中度缺血性卒中患者在入院后48小时内接受过夜HRPO检查。根据氧去饱和指数(ODI>10/h)将患者分为SDB组和非SDB组。采用逐步多变量逻辑回归分析来确定功能结局的相关预测因素（有利[mRS1-2分]与不利[mrS>=3分]）。
结果：在142名连续筛查的患者中，96个被包括在分析中。其中,33/96（34％）被鉴定为具有SDB，与没有SDB的人相比，更可能具有不利的mRS评分（优势比=2.70，p值=0.032）。
结论：HRPO可能是一种低成本且易于使用的筛查方法，可在急性缺血性卒中住院患者中检测SDB。在住院期间,与没有SDB的患者相比,具有SDB(由ODI定义)的患者具有更高的神经缺陷负担。
方法：急性轻中度缺血性卒中患者在入院后48小时内接受过夜HRPO检查。根据氧去饱和指数(ODI>10/h)将患者分为SDB组和非SDB组。采用逐步多变量逻辑回归分析来确定功能结局的相关预测因素（有利[mRS1-2分]与不利[mrS>=3分]）。
结果：在142名连续筛查的患者中，96个被包括在分析中。其中,33/96（34％）被鉴定为具有SDB，与没有SDB的人相比，更可能具有不利的mRS评分（优势比=2.70，p值=0.032）。
结论：HRPO可能是一种低成本且易于使用的筛查方法，可在急性缺血性卒中住院患者中检测SDB。在住院期间,与没有SDB的患者相比,具有SDB(由ODI定义)的患者具有更高的神经缺陷负担。
