■抗高血压药物是控制血压的有效方法。然而,一些研究报告说,它可能会影响患者在治疗期间的睡眠质量。由于目前的结果不一致,需要进行全面的系统评价和网络荟萃分析.
■电子数据库(MEDLINE,EMBASE,WEB的科学,PUBMED)被搜索到4月10日,2021年,包括不限制出版状态。随机对照试验(RCTs)或准实验研究或队列研究均符合条件。网络荟萃分析在贝叶斯框架内使用。
■最后,本研究包括16篇出版物(包括12项随机对照试验和4项准实验研究)和404名受试者。与安慰剂相比,网络荟萃分析结果显示,利尿剂可有效改善睡眠呼吸暂停,平均差异(MD)为-15.47(95%置信区间[CI]:-23.56,-6.59),与直接比较结果(MD:-17.91;95%CI-21.60,-14.23)一致.此外,利尿剂可有效增加夜间血氧饱和度,MD为3.64(95%CI0.07,7.46).然而,β受体阻滞剂的作用,钙通道阻滞剂,血管紧张素转换酶抑制剂,血管紧张素受体阻滞剂,和其他睡眠呼吸暂停没有统计学意义。此外,降压药对总睡眠时间(min)的影响,快速眼动(%),睡眠效率(%)无统计学意义。
■我们的研究发现,利尿剂可以有效降低高血压患者睡眠呼吸暂停的严重程度。然而,未发现抗高血压药物对睡眠特征的影响。
■在线版本包含补充材料,可在10.1007/s41105-022-00391-8获得。
UNASSIGNED: Antihypertensive medication is an effective way to control blood pressure. However, some studies reported that it may affect patients\' sleep quality during the treatment. Due to the inconsistency of present results, a comprehensive systematic review and network meta-analysis are needed.
UNASSIGNED: Electronic databases (MEDLINE, EMBASE, WEB OF SCIENCE, PUBMED) were searched up to April 10th, 2021 including no restriction of publication status. Randomized controlled trials (RCTs) or quasi-experimental studies or cohort studies were eligible. The network meta-analysis was used within a Bayesian framework.
UNASSIGNED: Finally, 16 publications (including 12 RCTs and 4 quasi-experimental studies) with 404 subjects were included in this study. Compared to placebo, the results of the network meta-analysis showed that diuretics were effective in improving sleep apnea with a mean difference (MD) of - 15.47 (95% confidence interval [CI]: - 23.56, - 6.59) which was consistent with the direct comparison result (MD: - 17.91; 95% CI - 21.60, - 14.23). In addition, diuretics were effective in increasing nocturnal oxygen saturation with an MD of 3.64 (95% CI 0.07, 7.46). However, the effects of β-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, and the others on sleep apnea were not statistically significant. Additionally, the effects of antihypertensive medication on the total sleep time (min), rapid eye movement (%), and sleep efficiency (%) were not statistically significant.
UNASSIGNED: Our study found that diuretics could effectively reduce the severity of sleep apnea in hypertensive patients. However, the effects of antihypertensive drugs on sleep characteristics were not found.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s41105-022-00391-8.