背景:CIC重排肉瘤(CRS)是一组异质性肿瘤,主要发生在四肢和躯干的软组织中,具有高侵袭性,预后不良。这里,我们描述了一例罕见的CRS病例,该病例在左肾出现aCIC-LEUTX重排.
方法:一名45岁男性因干咳入院2个月以上,无明显病因。体格检查和实验室检查未发现明显异常。CT扫描显示左肾肿块,两肺多发结节。经皮穿刺活检显示小圆细胞恶性肿瘤的组织形态和免疫表型相似。基因检测显示aCIC-LEUTX基因融合。
结论:我们提出了一个罕见的原发性肾CRS,伴有多个肺转移,在肾脏病例中,LEUTX首次被证实为CIC基因的融合伴侣。
CIC-rearranged sarcomas (CRS) are a group of heterogeneous tumors which mostly occur in the soft tissues of limbs and trunk, and are highly invasive with poor prognosis. Here, we describe a rare
case of CRS that occurred in the left kidney with a CIC-LEUTX rearrangement.
A 45-year-old male was admitted to hospital with a dry cough for more than two months without obvious cause. Physical examination and laboratory tests revealed no notable abnormality. The CT scan demonstrated a mass in the left kidney and multiple nodules in both lungs. The percutaneous core needle biopsy showed similar histomorphology and immunophenotype of small round cell malignant tumors. Genetic test revealed a CIC-LEUTX gene fusion.
We present a rare primary renal CRS with multiple pulmonary metastases, and LEUTX is confirmed as the fusion partner of CIC gene for the first time in a renal
case.