%0 Review
%T Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review.
%A Tang Y
%A Lu X
%A Zhan R
%J BMC Nephrol
%V 24
%N 1
%D 2023 11 30
%M 38036973
%F 2.585
%R 10.1186/s12882-023-03404-x
%X CIC-rearranged sarcomas (CRS) are a group of heterogeneous tumors which mostly occur in the soft tissues of limbs and trunk, and are highly invasive with poor prognosis. Here, we describe a rare case of CRS that occurred in the left kidney with a CIC-LEUTX rearrangement.<BR>A 45-year-old male was admitted to hospital with a dry cough for more than two months without obvious cause. Physical examination and laboratory tests revealed no notable abnormality. The CT scan demonstrated a mass in the left kidney and multiple nodules in both lungs. The percutaneous core needle biopsy showed similar histomorphology and immunophenotype of small round cell malignant tumors. Genetic test revealed a CIC-LEUTX gene fusion.<BR>We present a rare primary renal CRS with multiple pulmonary metastases, and LEUTX is confirmed as the fusion partner of CIC gene for the first time in a renal case.