{Reference Type}: Review
{Title}: Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review.
{Author}: Tang Y;Lu X;Zhan R;
{Journal}: BMC Nephrol
{Volume}: 24
{Issue}: 1
{Year}: 2023 11 30
{Factor}: 2.585
{DOI}: 10.1186/s12882-023-03404-x
{Abstract}: CIC-rearranged sarcomas (CRS) are a group of heterogeneous tumors which mostly occur in the soft tissues of limbs and trunk, and are highly invasive with poor prognosis. Here, we describe a rare case of CRS that occurred in the left kidney with a CIC-LEUTX rearrangement.
A 45-year-old male was admitted to hospital with a dry cough for more than two months without obvious cause. Physical examination and laboratory tests revealed no notable abnormality. The CT scan demonstrated a mass in the left kidney and multiple nodules in both lungs. The percutaneous core needle biopsy showed similar histomorphology and immunophenotype of small round cell malignant tumors. Genetic test revealed a CIC-LEUTX gene fusion.
We present a rare primary renal CRS with multiple pulmonary metastases, and LEUTX is confirmed as the fusion partner of CIC gene for the first time in a renal case.