背景:胃癌是感染相关的恶性肿瘤之一。除了幽门螺杆菌和EB病毒(EBV),其他肿瘤病毒可能在胃癌的发生发展中起着潜在的作用。本系统综述和荟萃分析旨在全面审查和评估EBV以外的癌病毒与胃癌风险的关联。以识别任何潜在的致癌病毒。鉴定或否认某些致癌病毒可能是胃癌危险因素的候选病毒。据我们所知,除EBV外,与胃癌风险相关的癌病毒没有全面综述.积极的发现可能有助于建议进一步的机制调查和高风险亚群的建议。
方法:PubMed数据库将在2018年12月31日之前进行搜索。研究,在组织学证实的胃癌病例和健康或非恶性对照之间,比较了EBV以外的任何肿瘤病毒的阳性,有资格。在组织或血液中检测癌病毒是可接受的。选择,质量评估(纽卡斯尔-渥太华量表),符合条件的研究的数据提取将由2名独立评审员进行.任何癌病毒的合并流行率将通过meta分析进行组合。将通过荟萃分析估计胃癌病例和对照组之间的汇总比值比。异质性和发表偏倚将被测试。在敏感性分析中,在适用的情况下,将采用留一法和排除低功率研究。
结果:由于文献性质,本综述未提交任何伦理批准。结果将发表在期刊上,并在学术会议上发表。PROSPERO国际前瞻性系统审查登记册的注册号为CRD42015029703。
结论:据我们所知,除EBV外,与胃癌风险相关的癌病毒没有全面综述.积极的发现可能有助于建议进一步的机制调查和高风险亚群的建议。
BACKGROUND: Gastric cancer is one of the infection associated malignancies. In addition to Helicobacter pylori and Epstein-Barr virus (EBV), other oncoviruses might play potential roles in the development of gastric cancer. Associations of oncoviruses other than EBV with gastric cancer risk are aimed to be comprehensively reviewed and assessed in this systematic
review and meta-analysis, to identify any potentially causative oncovirus. It might be informative to identify or deny certain oncoviruses which are candidates of risk factor for gastric cancer. To our knowledge, there is no comprehensive
review on oncoviruses other than EBV associated with gastric cancer risk. Positive findings might be helpful to suggest further mechanism investigation and high-risk subpopulation recommendation.
METHODS: PubMed database will be searched up to Dec 31, 2018. The studies, compared the positivity of any oncovirus other than EBV between cases with histologically proven gastric cancer and healthy or nonmalignant controls, are eligible. The detection of oncovirus either in tissue or blood is acceptable. Selection, quality assessment (Newcastle-Ottawa Scale), and data extraction of eligible studies will be performed by 2 independent reviewers. Pooled prevalence of any oncovirus will be combined by meta-analysis for rate. Pooled odds ratio between gastric cancer cases and controls will be estimated by meta-analysis. Heterogeneity and publication bias will be tested. In sensitivity analysis, the leave-one-out method and exclusion of low power studies will be applied where applicable.
RESULTS: This
review was not submitted for any ethical approval due to the literature-based nature. The results will be published in a journal and presented at conferences for academic purposes.Registration number was CRD42015029703 in the PROSPERO International Prospective Register of Systematic Reviews.
CONCLUSIONS: To our knowledge, there is no comprehensive
review on oncoviruses other than EBV associated with gastric cancer risk. Positive findings might be helpful to suggest further mechanism investigation and high-risk subpopulation recommendation.