狂犬病是一种动物源性传染病,死亡率高。在狂犬病的早期阶段,狂犬病病毒(RABV)通常在唾液和脑脊液(CSF)中检测不到。此外,仍然没有有效的药物和治疗方法。这里,我们提出了一个案例,其中血液净化缓解了多系统故障。患者是一名45岁的妇女,她对水和风感到恐惧,躁动,和多动症。通过高通量测序下一代测序(NGS)和聚合酶链反应(PCR)在她的唾液中检测到RABV。根据典型的临床症状以及NGS和PCR的结果,病人被诊断为狂犬病确诊病例。血液透析联合抗病毒治疗和重症监护病房(ICU)治疗可有效缓解循环衰竭,呼吸衰竭,和肾衰竭。最后,她在入院第34天死于脑死亡。病例报告显示血液净化对狂犬病引起的器官衰竭呈阳性。血液净化联合抗病毒治疗能在一定程度上延长狂犬病患者的生命。
Rabies is an infectious disease of animal origin with a high mortality rate. In the early stages of rabies, the rabies virus (RABV) is usually undetectable in saliva and cerebrospinal fluid (CSF). In addition, there are still no effective drugs and treatments. Here, we present a
case in which blood purification alleviated multisystem failures. The patient was a 45-year-old woman who presented with the fear of water and wind, restlessness, and hyperactivity. RABV was detected in her saliva by high-throughput sequencing Next Generation Sequencing (NGS) and polymerase chain reaction (PCR). Based on typical clinical symptoms and the result of NGS and PCR, the patient was diagnosed as a confirmed
case of rabies. Hemodialysis combined with antiviral therapy and intensive care unit (ICU) treatment can effectively relieve circulatory failure, respiratory failure, and renal failure. Finally, she died of brain death on the 34th day of admission. The
case report showed that blood purification was positive for rabies-induced organ failure. Blood purification combined with antiviral therapy can prolong the lives of patients with rabies to some extent.