阿尔茨海默病(AD)仍然是最强大的神经系统疾病之一,影响全球数百万人。这篇综述提供了治疗策略的整体概述,既传统又新颖,旨在减轻AD的影响。最初,我们深入研究传统方法,强调乙酰胆碱酯酶(AChE)抑制的作用,这一直是广告管理的基石。随着我们对AD的理解的发展,出现了几种新的潜在方法。我们讨论了丁酰胆碱酯酶(BChE)抑制的有希望的作用,Tau蛋白抑制剂,COX-2抑制,PPAR-γ激动作用,和FAHH抑制,在其他人中。内源性大麻素(eCB)系统的潜力,降胆固醇药物,金属螯合剂,还探索了MMPs抑制剂,最终探索microRNA在AD进展中的关键作用。与这些治疗见解并行,我们揭示了革新AD研究的新工具和方法。从通过qRTPCR定量分析基因表达到使用诱导多能干细胞(iPSCs)评估线粒体功能,诊断和研究工具的进步提供了新的希望。此外,我们探索临床试验的现状,强调主要的药物干预措施及其各自的发展阶段。这次全面审查最后展望了未来的前景,捕捉地平线上潜在的突破和创新。通过对当前知识和新兴研究的综合,本文旨在为临床医生提供综合资源,研究人员,和老年痴呆症领域的院士。
Alzheimer\'s disease (AD) remains one of the most formidable neurological disorders, affecting millions globally. This
review provides a holistic overview of the therapeutic strategies, both conventional and novel, aimed at mitigating the impact of AD. Initially, we delve into the conventional approach, emphasizing the role of Acetylcholinesterase (AChE) inhibition, which has been a cornerstone in AD management. As our understanding of AD evolves, several novel potential approaches emerge. We discuss the promising roles of Butyrylcholinesterase (BChE) inhibition, Tau Protein inhibitors, COX-2 inhibition, PPAR-γ agonism, and FAHH inhibition, among others. The potential of the endocannabinoids (eCB) system, cholesterol-lowering drugs, metal chelators, and MMPs inhibitors are also explored, culminating in the exploration of the pivotal role of microRNA in AD progression. Parallel to these therapeutic insights, we shed light on the novel tools and methodologies revolutionizing AD research. From the quantitative analysis of gene expression by qRTPCR to the evaluation of mitochondrial function using induced pluripotent stem cells (iPSCs), the advances in diagnostic and research tools offer renewed hope. Moreover, we explore the current landscape of clinical trials, highlighting the leading drug interventions and their respective stages of development. This comprehensive
review concludes with a look into the future perspectives, capturing the potential breakthroughs and innovations on the horizon. Through a synthesis of current knowledge and emerging research, this article aims to provide a consolidated resource for clinicians, researchers, and academicians in the realm of Alzheimer\'s disease.