目的:评估体重指数(BMI)和血红蛋白A1c(HbA1c)与血清前列腺特异性抗原(PSA)水平之间的关系。
方法:利雅得费萨尔国王专科医院和研究中心进行了一项回顾性队列研究,沙特阿拉伯,从2016年1月到2021年12月。数据是从去过家庭医学诊所的患者的医疗记录中收集的,包括人口统计,吸烟状况,BMI值,PSA水平指数,睾酮水平,直肠指检结果,前列腺活检状态,空腹血糖(FBG),HbA1c,糖尿病持续时间,慢性合并症(即,高血压,血脂异常,或慢性肾脏疾病),和用药史。
结果:平均PSA水平为1.89±4.02ng/dL,平均HbA1c为6.59±2.69%。在参与者中,41.8%的人超重,非糖尿病患者占54.3%,85.3%为非吸烟者。只有11名(1.6%)的参与者在进行PSA测试后进行了前列腺活检。PSA水平与年龄呈正相关,PSA水平与BMI呈负相关,PSA水平与HbA1c或FBG无相关性。
结论:老年人和低BMI人群的前列腺特异性抗原水平较高。PSA水平与HbA1c或FBG无相关性,即使在调整了其他变量之后。此外,PSA水平与血脂异常等其他合并症之间没有发现相关性,慢性肾病,和高血压。
OBJECTIVE: To assess the association between body mass index (BMI) and hemoglobin A1c (HbA1c) with serum prostate-specific antigen (PSA) level.
METHODS: A retrospective cohort
study was carried out at King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia, from January 2016 to December 2021. Data were collected from the medical records of patients who visited the family medicine clinics, including demographics, smoking status, BMI value, index PSA level, testosterone level, digital rectal exam findings, prostate biopsy status, fasting blood glucose (FBG), HbA1c, diabetes duration, chronic comorbidities (namely, hypertension, dyslipidemia, or chronic kidney disease), and medication history.
RESULTS: The mean PSA level was 1.89±4.02 ng/dL and mean HbA1c was 6.59±2.69%. Of the participants, 41.8% were overweight, 54.3% were non-diabetics, and 85.3% were nonsmokers. Only 11 (1.6%) participants had undergone a prostate biopsy after taking a PSA test. There was a positive correlation between PSA level and age, a negative correlation between PSA level and BMI, and no correlation between PSA level and HbA1c or FBG.
CONCLUSIONS: Prostate-specific antigen levels were higher in older people and those with low BMIs. No correlations were found between PSA levels and HbA1c or FBG, even after adjusting for other variables. Moreover, no correlations were found between PSA levels and other comorbidities such as dyslipidemia, chronic kidney disease, and hypertension.