■氧化平衡评分(OBS)是影响饮食和生活方式因素的氧化应激的指标。我们旨在探讨OBS与老年男性前列腺特异性抗原(PSA)的相关性。
■本研究共收集了5,136个样本,以调查来自国家健康和营养检查调查的OBS与PSA之间的关系。使用Logistic回归模型和有限的三次样条来评估OBS和PSA之间的关联。
■与Q1组相比,OBS和PSA之间关联的优势比为1.005(1.003,1.009),1.003(1.001,1.006),第二季度、第三季度和第四季度分别为1.001(0.978、1.022)。在特定年龄的分析中,该关联在65岁及以上的个体中是显著的:OBS和PSA之间关联的比值比为1.019(1.005,1.028),1.028(1.018,1.039),第二季度、第三季度和第四季度分别为1.038(1.022、1.049)。但这在65岁以下的个体中并不显著:OBS和PSA之间关联的比值比为1.016(0.995,1.026),1.015(0.985,1.022),Q2、Q3和Q4分别为0.988(0.978、1.016)。有限的三次样条还表明65岁及以上的个体之间的OBS和PSA之间存在非线性关系(总体=0.006,非线性=0.021)。
■我们的发现提供了证据,表明OBS与老年人PSA水平升高呈正相关。需要进一步的大规模前瞻性队列研究来验证我们的发现。
Oxidative Balance Score (OBS) is an index affecting the oxidative stress of dietary and lifestyle factors. We aimed to explore the association of OBS with prostate specific antigen (PSA) among older males.
A total of 5,136 samples were collected in this study to investigate the relationship between OBS and PSA from the National Health and Nutrition Examination Survey. Logistic regression models and restricted cubic spline were used to assess the associations between OBS and PSA.
Compared with the Q1 group, the odds ratios for the association between OBS and PSA were 1.005 (1.003, 1.009), 1.003 (1.001, 1.006), and 1.001 (0.978, 1.022) for Q2, Q3, and Q4, respectively. In the age-specific analyses, the association was significant among individuals aged 65 years old and over: the odds ratios for the association between OBS and PSA were 1.019 (1.005, 1.028), 1.028 (1.018, 1.039), and 1.038 (1.022, 1.049) for Q2, Q3, and Q4, respectively. But it was not significant among individuals aged less than 65 years old: the odds ratios for the association between OBS and PSA were 1.016 (0.995, 1.026), 1.015 (0.985, 1.022), and 0.988 (0.978, 1.016) for Q2, Q3, and Q4, respectively. The restricted cubic splines also indicated a nonlinear relationship between OBS and PSA among individuals aged 65 years old and over (Poverall = 0.006, Pnonlinear = 0.021).
Our findings provide evidence that OBS is positively associated with higher levels of PSA among older adults. Further large-scale prospective cohort studies are needed to verify our findings.