Population Groups

人口群体
  • 文章类型: Journal Article
    目的:本研究的目的是评估全球土著和部落人群中丙型肝炎病毒(HCV)暴露和感染的患病率。
    方法:系统评价和荟萃分析。
    方法:我们系统地检索了书目数据库和灰色文献(1/01/2000-16/06/2022)。总体上综合了患病率估计,世界卫生组织地区和HCV风险组。对于比较人群的研究,对患病率比率进行了估计和汇总.
    结果:纳入了92项研究。全球范围内,在一般土著和部落人口中,HCV抗体(HCVAb)的中位患病率为1.3%(四分位数范围[IQR]:0.3-3.8%,I2=98.5%),HCVRNA为0.4%(IQR:0-1.3%,I2=96.1%)。西太平洋区域的患病率最高(HCVAb:中位数:3.0%[IQR:0.4-11.9%],HCVRNA:中位数5.6%[IQR:2.0-8.8%])。注射药物的人的患病率最高(HCVAb:中位数:59.5%,IQR:51.5-67.6%,I2=96.6%;和HCVRNA:中位数:29.4%,IQR:21.8-35.2%,I2=97.2%)。对于一般人群(患病率=0.91;95%CI:0.56,1.49)或关键风险组,HCVAb患病率与土著/部落状态之间没有关联。
    结论:来自西太平洋区域的土著和部落民族以及公认的高危人群的HCV患病率较高。HCV患病率与土著/部落身份无关。然而,这篇综述受到成分研究的异质性和低质量的限制,土著/部落地位的不同定义,区域数据差距,以及对慢性感染(HCVRNA)的有限研究。需要针对土著和部落人民的HCV流行病学提供全面的质量证据,以制定预防和治疗干预措施,以使这些人群在消除努力中不会落后。
    OBJECTIVE: The objective of this study was to estimate prevalence of hepatitis C virus (HCV) exposure and infection among Indigenous and tribal populations globally.
    METHODS: Systematic review and meta-analysis.
    METHODS: We systematically searched bibliographic databases and grey literature (1/01/2000-16/06/2022). Prevalence estimates were synthesised overall, by World Health Organization region and HCV-risk group. For studies with comparator populations, prevalence ratios were estimated and pooled.
    RESULTS: Ninety-two studies were included. Globally, among general Indigenous and tribal populations, the median prevalence of HCV antibody (HCV Ab) was 1.3% (interquartile range [IQR]: 0.3-3.8%, I2 = 98.5%) and HCV RNA was 0.4% (IQR: 0-1.3%, I2 = 96.1%). The Western Pacific Region had the highest prevalence (HCV Ab: median: 3.0% [IQR: 0.4-11.9%], HCV RNA: median 5.6% [IQR: 2.0-8.8%]). Prevalence was highest in people who injected drugs (HCV Ab: median: 59.5%, IQR: 51.5-67.6%, I2 = 96.6%; and HCV RNA: median: 29.4%, IQR: 21.8-35.2%, I2 = 97.2%). There was no association between HCV Ab prevalence and Indigenous/tribal status for general populations (prevalence ratio = 0.91; 95% CI: 0.56, 1.49) or key risk groups.
    CONCLUSIONS: Indigenous and tribal peoples from the Western Pacific Region and recognised at-risk sub-populations had higher HCV prevalence. HCV prevalence showed no association with Indigenous/tribal status. However, this review was limited by heterogeneity and poor quality of constituent studies, varying definitions of Indigenous/tribal status, regional data gaps, and limited studies on chronic infection (HCV RNA). Comprehensive quality evidence on HCV epidemiology in Indigenous and tribal peoples is needed to tailor preventive and treatment interventions so these populations are not left behind in elimination efforts.
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  • 文章类型: Review
    背景:尽管社区对医院康复服务的兴趣与日俱增,由于社区卫生服务发展和区域文化多样性的局限性,对现有社区康复(CBR)服务的研究仍然很少。作为确保康复服务质量和实现预期服务成果的保证措施,在多学科团队中明确的角色和责任以及有效的服务交付尤为重要。
    目的:本范围审查旨在确定涉及现有多学科团队的社区卒中康复计划的范围,并分析实施内容和实施者的功能角色,为未来的CBR计划提供指导。
    方法:范围审查设计遵循JoannaBriggs研究所的方法,并基于Arksey和O\'Malley提出的规范性范围审查框架。全面的CBR框架是由世界卫生组织指导的数据图表和分析提出的。
    结果:在22,849个确定的引文中,包括74项研究,由6,809名中风患者和49名主要护理人员组成,其中大部分来自中国。CBR计划中最常见的工作模式是双重方法,涉及医疗机构中的医疗保健专业人员和社区医疗保健专业人员。每个学科的程序数量按以下降序排列:护理,医疗保健,康复,心理学,营养,和公共卫生。其中,多学科团队包括医疗,护理,康复学科是最常见的,共有29个项目。纪律委员主要负责落实各自的纪律内容,医生为项目提供指导。超过82.4%的研究报告了2-4种干预策略。康复内容的干预形式最为多样,而预防性干预措施比其他干预措施更同质。身体功能和社会心理测量是最常见的结果。
    结论:多学科团队实施的CBR服务可以有效地改善中风患者的功能和情绪,护士参与最多,尤其是在社区环境中。结果进一步强调了加强探索护士在未来实践中实施CBR计划的最大潜力的重要性。
    背景:可以在osf.io/pv7tg上找到此范围审查的注册信息。
    BACKGROUND: Despite the growing interest in hospital rehabilitation services for communities, studies on existing community-based rehabilitation (CBR) services remain scarce owing to limitations in the development of community health services and regional cultural diversity. As a guaranteed measure for ensuring the quality of rehabilitation services and achieving the desired service outcomes, clear roles and responsibilities in multidisciplinary teams and effective service delivery are particularly important.
    OBJECTIVE: This scoping review aimed to determine the scope of community stroke rehabilitation programs involving existing multidisciplinary teams and to analyze the implementation content and implementers\' functional roles to provide guidance for future CBR programs.
    METHODS: The scoping review design followed the methodology of the Joanna Briggs Institute and was based on the normative scoping review framework proposed by Arksey and O\'Malley. The comprehensive CBR framework was proposed by World Health Organization-guided data charting and analysis.
    RESULTS: Of the 22,849 identified citations, 74 studies were included, consisting of 6,809 patients with stroke and 49 primary caregivers, most of whom were from China. The most common working mode in CBR programs was a dual approach involving both healthcare professionals in medical institutions and community healthcare professionals. The number of programs in each discipline was in the following descending order: nursing, medical care, rehabilitation, psychology, nutrition, and public health. Among these, multidisciplinary teams comprising medical, nursing, and rehabilitation disciplines were the most common, with a total of 29 programs. Disciplinary members were mainly responsible for implementing their respective disciplinary content, with physicians providing guidance for the programs. More than 82.4% of the studies reported 2-4 intervention strategies. The intervention forms of rehabilitation content were the most diverse, whereas preventive interventions were more homogeneous than others. Physical function and socio-psychological measurements were the most commonly reported outcomes.
    CONCLUSIONS: CBR services implemented by multidisciplinary teams can effectively achieve functional and emotional improvement in patients with stroke, and nurses are the most involved in implementation, especially in community settings. The results further emphasize the importance of strengthening the exploration of nurses\' maximum potential to implement CBR plans in future practice.
    BACKGROUND: The registration information for this scoping review can be found at osf.io/pv7tg.
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  • 文章类型: Journal Article
    应该支持老年人享有最佳的生活质量。卫生专业人员应考虑一系列干预措施,以支持老年人口维持其生活质量。一种这样的介入方法涉及精神护理。
    探索对居住在社区中的老年人的精神护理方法的了解。
    由乔安娜·布里格斯研究所指南提供的范围审查。搜索了八个电子数据库:CINAHL,Ageline,PubMed,ProQuest护理和联合健康,PsycINFO,Scopus,Garuda,还有Neliti.该综述包括定量和定性的主要同行评审研究,重点是2011年至2021年之间以英语或印度尼西亚语发表的社区老年人的精神护理干预措施。搜索被上传到电子引文管理器,并导入到Covidence进行筛选。
    共29项研究纳入本综述。虽然这些研究是在五大洲进行的,大部分来自亚洲大陆。发现了基于干预结果的五个关键问题,即心理,物理,精神,多学科方法,和社会关系。
    这项范围审查确定了在许多国家/地区进行的精神干预措施已针对居住在社区中的老年人实施。虽然有审查的局限性,需要进一步的研究,这些精神干预,基于信仰和非信仰,被认为对支持老年人的福祉有用。
    UNASSIGNED: The population of older people should be supported to enjoy optimal quality of life. Health professionals should consider a range of interventions that support the older population to maintain their quality of life. One such interventional approach involves spiritual care.
    UNASSIGNED: To explore what is known about spiritual care approaches for older people living in the community.
    UNASSIGNED: Scoping review informed by Joanna Briggs Institute guidelines. Eight electronic databases were searched: CINAHL, Ageline, PubMed, ProQuest Nursing & Allied Health, PsycINFO, Scopus, Garuda, and Neliti. The review included quantitative and qualitative primary peer-reviewed research studies focusing on spiritual care interventions for older people living in the community published between 2011 and 2021 in English or Bahasa Indonesia. The search was uploaded into an electronic citation manager and imported into Covidence for screening.
    UNASSIGNED: A total of 29 studies were included in the review. While the studies were conducted in five continents, most were reported from the Asian continent. Five key issues based on the outcome of interventions were found namely psychological, physical, spiritual, multidisciplinary approach, and social connection.
    UNASSIGNED: This scoping review identifies spiritual interventions conducted across many countries have been implemented for older people living in the community. Although there are review limitations and further research is needed, these spiritual interventions, both faith-based and non-faith-based, are identified as useful to support the well-being of older people.
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  • 文章类型: Journal Article
    背景:卫生领域一直面临着欺诈行为和“庸医”盛行的挑战。许多案例引起了这个问题。因此,本研究旨在全面调查和分类庸医在医疗保健中的原因和后果。
    方法:范围审查,使用Arksey和O\'Malley的框架的5个阶段,进行了文献检索和分析。包括PubMed在内的国际数据库,Scopus,搜索了Embase和WebofScience以及伊朗国家数据库,以查找同行评审的英语和波斯语出版文献。灰色文献也包括在内。通过归纳的方法应用元综合来分析研究结果。
    结果:在3794项最初确定的研究中,本研究选择了30名。根据这项研究的结果,庸医的健康原因分为六类:政治、经济,社会文化,技术组织,法律和心理。此外,这个问题的后果分为三类:健康,经济和社会。经济和社会因素被发现对卫生部门庸医的流行有更显著的影响。法律和技术组织因素在促进欺诈行为方面发挥了关键作用,造成严重的健康后果。
    结论:很明显,管理机构和卫生系统必须优先解决经济和社会因素,以打击卫生部门的欺诈行为。应特别注意文化发展和社区教育问题,以加强导致社会获得标准的负担得起的服务的机制。还要努力提高立法效率,有效解决这一问题的实施和评估系统。
    BACKGROUND: The field of health has been facing challenges with fraudulent practices and the prevalence of \"quack medicine\". Many cases have given rise to this issue. Therefore, this study aims to comprehensively investigate and categorize the causes and consequences of quack medicine in the healthcare.
    METHODS: A scoping review, using the 5 stages of Arksey and O\'Malley\'s framework, was conducted to retrieve and analyze the literature. International databases including the PubMed, Scopus, Embase and Web of Science and also national Iranian databases were searched to find peer reviewed published literature in English and Persian languages. Grey literature was also included. Meta-Synthesis was applied to analyze the findings through an inductive approach.
    RESULTS: Out of 3794 initially identified studies, 30 were selected for this study. Based on the findings of this research, the causes of quackery in the health were divided into six categories: political, economic, socio-cultural, technical-organizational, legal and psychological. Additionally, the consequences of this issue were classified into three categories: health, economic and social. Economic and social factors were found to have a more significant impact on the prevalence of quackery in the health sector. Legal and technical-organizational factors played a crucial role in facilitating fraudulent practices, resulting in severe health consequences.
    CONCLUSIONS: It is evident that governing bodies and health systems must prioritize addressing economic and social factors in combating quackery in the health sector. Special attention should be paid to the issue of cultural development and community education to strengthen the mechanisms that lead to the society access to standard affordable services. Efforts should be made also to improve the efficiency of legislation, implementation and evaluation systems to effectively tackle this issue.
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  • 文章类型: Journal Article
    背景:研究土著人民的健康和福祉与气候变化和生物多样性丧失的交叉点在全球奖学金中非常丰富。为了绘制当前的影响路径,这种证据基础的综合至关重要,以及确定全球文献中促进土著健康和福祉的回应,同时以土著的声音和观点为中心。该协议详细介绍了我们提出的方法,以系统地对气候变化的综合文献进行总括审查(或审查)。生物多样性丧失,以及全球土著人民的健康和福祉。
    方法:由土著和非土著学者组成的多学科小组将进行审查,在与土著专家组的参与过程的指导下。搜索对冲将用于搜索PubMed®,Scopus®,WebofScience™,CINAHL(通过EBSCOHost®),和坎贝尔合作数据库,并适用于灰色文献来源。两名独立审稿人将使用纳入/排除标准进行一级(标题/摘要)和二级(全文)资格筛选。将从包含的记录中提取数据,并使用定量分析(例如,基本描述性统计)和定性方法(例如,专题分析,使用恒定的比较法)。
    结论:本协议概述了我们系统地和透明地审查综合文献的方法,这些文献检查了气候变化的交叉点,生物多样性丧失,以及全球土著人民的健康和福祉。
    背景:该方案于2023年4月24日在国际前瞻性系统审查注册中心(PROSPERO)注册(注册号:CRD42023417060)。
    Research that examines the intersections of Indigenous Peoples\' health and wellbeing with climate change and biodiversity loss is abundant in the global scholarship. A synthesis of this evidence base is crucial in order to map current pathways of impact, as well as to identify responses across the global literature that advance Indigenous health and wellbeing, all while centering Indigenous voices and perspectives. This protocol details our proposed methodology to systematically conduct an umbrella review (or review of reviews) of the synthesized literature on climate change, biodiversity loss, and the health and wellbeing of Indigenous Peoples globally.
    A multidisciplinary team of Indigenous and non-Indigenous scholars will conduct the review, guided by an engagement process with an Indigenous Experts group. A search hedge will be used to search PubMed®, Scopus®, Web of Science™, CINAHL (via EBSCOHost®), and Campbell Collaboration databases and adapted for use in grey literature sources. Two independent reviewers will conduct level one (title/abstract) and level two (full-text) eligibility screening using inclusion/exclusion criteria. Data will be extracted from included records and analyzed using quantitative (e.g., basic descriptive statistics) and qualitative methods (e.g., thematic analysis, using a constant comparative method).
    This protocol outlines our approach to systematically and transparently review synthesized literature that examines the intersections of climate change, biodiversity loss, and Indigenous Peoples\' health and wellbeing globally.
    This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on April 24, 2023 (registration number: CRD42023417060).
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  • 文章类型: Journal Article
    背景:个人健康的风险应与环境一起考虑,他们生活的社会文化和社会政治背景。环境制图是一种确定社区内健康的推动者和障碍的方法。土著指标分类系统(IICS)框架已用于绘制澳大利亚土著社区的环境图。IICS是一个四级嵌套分层框架,主题组包括文化,社会政治,建立在层次结构的顶部,指标在底部。这次范围审查的目的是绘制文化地图,社会政治,环境和建筑资产,支持每个托雷斯海峡岛社区存在的健康和福祉。
    方法:此审查将根据JoannaBriggsInstitute(JBI)用于范围审查的方法进行。它将包括识别文化的来源,社会政治,环境和建筑资产,支持每个托雷斯海峡岛社区存在的健康和福祉。要搜索的数据库包括:Informit;Scopus;WebofScience;HealthInfoNet,BioOne完整和绿色文件。未出版和灰色文献的来源将使用Google和GoogleScholar进行定位。搜索将仅限于自2018年1月以来发布的英语语言和文献,以确保绘制的资产反映每个岛屿的当前状况。回答研究问题的数据将从来源中提取,并记录在IICS的改编中。数据的定量分析将包括对各个岛屿及其相关集群的每个资产进行求和。数据将以图形方式呈现,图解,或以表格形式,取决于哪种方法最能传达其含义。
    背景:远北昆士兰人类研究伦理委员会(参考HREC/2022/QCH/88155-1624)已批准本研究。研究小组的托雷斯海峡岛民成员将通过会议和同行评审的出版物来领导审查结果的传播。
    Risks to an individual\'s health should be considered alongside the environmental, sociocultural and sociopolitical context(s) in which they live. Environmental mapping is an approach to identifying enablers and barriers to health within a community. The Indigenous Indicator Classification System (IICS) framework has been used to map the environment in Australian Indigenous communities. The IICS is a four-level nested hierarchical framework with subject groups including culture, sociopolitical and built at the top of the hierarchy and indicators at the bottom. The objective of this scoping review is to map the cultural, sociopolitical, environmental and built assets that support health and well-being that exist in each Torres Strait Island community.
    This review will be conducted according the Joanna Briggs Institute (JBI) method for scoping reviews. It will include sources that identify cultural, sociopolitical, environmental and built assets that support health and well-being that exist in each Torres Strait Island community. Databases to be searched include: Informit; Scopus; Web of Science; HealthInfoNet, BioOne Complete and Green File. Sources of unpublished and grey literature will be located using Google and Google Scholar. Searches will be limited to the English language and literature published since January 2018 to ensure that the assets mapped reflect current conditions on each island. Data that answers the research question will be extracted from sources and recorded in an adaptation of the IICS. Quantitative analysis of the data will include summing each asset for individual islands and their associated clusters. Data will be presented graphically, diagrammatically, or in tabular form depending on what approach best conveys its meaning.
    The Far North Queensland Human Research Ethics Committee (reference HREC/2022/QCH/88 155-1624) has approved this study. Dissemination of the review\'s findings will be led by Torres Strait Islander members of the research team through conferences and peer-reviewed publications.
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  • 文章类型: Journal Article
    本系统综述旨在评估与奥林匹克格斗运动(OCS)对非运动员人群心肺适应性(CRF)影响有关的已发表同行评审文章的可用数据。使用PRISMA评估方法学质量和证据的确定性,TESTEX,RoB,和等级尺度。该协议在PROSPERO(代码:CRD42023391433)中注册。从4133条记录中,纳入6项随机对照试验,涉及855名非运动员(平均年龄=27.2岁)。TESTEX量表报告了所有评分≥60%(中-高质量)的研究。GRADE量表表示证据的中低确定性。只能对最大耗氧量(VO2max)的直接方法进行荟萃分析。主要结果表明,与VO2max的主动/被动对照相比,OCS的支持存在显着差异(SMD=4.61;95CI=1.46至7.76;I2=99%;p=0.004),而研究的个别结果报道了对CRF的间接方法有利的OCS的显着改善。OCS在不同年龄的健康非运动员人群中提高了CRF,特别是通过直接测试显示VO2max的显着改善,比如心肺检查。然而,报告了中度到低度的证据确定性,因此无法建立明确的建议。
    This systematic review aimed to assess the available body of published peer-reviewed articles related to the effects of Olympic combat sports (OCS) on cardiorespiratory fitness (CRF) in the non-athlete population. The methodological quality and certainty of evidence were evaluated using PRISMA, TESTEX, RoB, and GRADE scales. The protocol was registered in PROSPERO (code: CRD42023391433). From 4133 records, six randomized controlled trials were included, involving 855 non-athletes (mean age = 27.2 years old). The TESTEX scale reported all studies with a ≥ 60% (moderate-high quality) score. The GRADE scale indicated moderate to low certainty of evidence. It was only possible to perform a meta-analysis on direct methods to maximum oxygen consumption (VO2max). The main results indicated significant differences in favor of OCS compared to active/passive controls in VO2max (SMD = 4.61; 95%CI = 1.46 to 7.76; I2 = 99%; p = 0.004), while the individual results of the studies reported significant improvements in favor of the OCS on the indirect methods of the CRF. OCS improved CRF in a healthy non-athlete population of different ages, specifically showing a significant improvement in VO2max with direct tests, such as cardiopulmonary tests. However, moderate to low certainty of evidence is reported, so no definitive recommendations can be established.
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  • 文章类型: Review
    背景:由于孤独对健康和福祉的有害影响,孤独是一个重要的公共卫生问题。尽管残疾人报告的孤独感程度高于普通人群,关于这如何影响他们的健康和福祉的研究很少。鉴于此,我们研究的目的是对现有的关于与残疾人孤独相关的健康和福祉结果的证据进行范围划分,以及在这一研究领域使用的概念框架和措施。
    方法:要进行此范围审查,我们遵循了JBI概述的方法,并搜索了MEDLINE,Scopus,提供信息,Embase,和WebofScience进行同行评审,2000年1月1日至2023年2月8日期间发表的英文文章。两名独立审稿人完成了筛选,全文回顾和数据提取,在每个阶段都寻求共识。使用内容分析对数据进行了分析,并以数字和叙述方式呈现。
    结果:在范围审查中确定的最初1602出版物中,重复删除后只包括9个,标题和摘要筛选,和全文回顾。研究数量有限,最早的一项研究发表于2015年,代表了一个关键发现。九项研究中有八项是定量的,所有这些都是在高收入国家进行的。这些研究中的大多数都使用了洛杉矶大学孤独量表的一个版本来衡量孤独感,并解决了特定的障碍群体。值得注意的是,大多数研究确定了孤独感与残疾人的健康和福祉之间的关联。
    结论:这项范围审查强调了目前缺乏研究孤独对残疾人的健康和福祉结果的影响的研究。由于大多数经过审查的研究都依赖于为无残疾人士设计的孤独感措施,他们可能忽视了残疾人独特的生活经历。鉴于孤独是一个国际公共卫生问题,在解决孤独对健康和福祉的影响的努力中,残疾人必须不要落后或被忽视。
    Loneliness is a significant public health concern due to its detrimental impact on health and wellbeing. Despite people with disability reporting higher levels of loneliness than the general population, there has been little research into how this is affecting their health and wellbeing. In light of this, the aim of our study was to scope both the existing evidence about the health and wellbeing outcomes associated with loneliness for people with disability, as well as the conceptual frameworks and measures utilised in this field of research.
    To conduct this scoping review, we followed the methodology outlined by JBI and searched MEDLINE, Scopus, Informit, Embase, and Web of Science for peer-reviewed, English-language articles published between 1 January 2000 and 8 February 2023. Two independent reviewers completed screening, full-text review and data extraction, with consensus sought at each stage. Data were analysed using content analysis and presented both numerically and narratively.
    Out of the initial 1602 publications identified in the scoping review, only nine were included after duplicate removal, title and abstract screening, and full-text review. This limited number of studies, with the earliest study one published in 2015, represents a key finding. Eight of the nine studies were quantitative, and all were conducted in high income countries. Most of these studies utilised a version of the University of Los Angles Loneliness Scale to measure loneliness and addressed specific impairment groups. Notably, most of the studies identified associations between loneliness and health and wellbeing outcomes for people with disability.
    This scoping review highlights the current scarcity of studies examining the effect that loneliness has on the health and wellbeing outcomes of people with disability. As most of the reviewed studies relied on loneliness measures designed for individuals without disability, they potentially overlook the unique life experiences of people with disability. Given that loneliness is an international public health concern, it is imperative that people with disability are not left behind or overlooked in efforts to address the impact of loneliness on health and wellbeing.
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  • 文章类型: Systematic Review
    背景:心血管疾病是世界范围内一些主要的死亡原因,在发展中国家和发达国家,冠状动脉疾病是导致死亡的主要原因之一。尽管流行,在非欧洲血统的人群中进行的研究数量很少,由于此类研究的样本量有限,进一步限制了各自研究结果的功效和普遍性。这项研究旨在了解不同祖先人群中冠状动脉疾病(CAD)遗传结构的差异,以有助于理解冠状动脉疾病的病理生理学。
    方法:我们在10月6日进行了系统评价,2022年总结了冠状动脉疾病的全基因组关联研究,同时使用GWAS目录作为独立的数据库来支持搜索。我们开发了一个框架来评估每个研究的方法学质量。我们根据参与者的祖先组提取并分组相关的单核苷酸多态性和基因。
    结果:我们确定了3100项研究,其中,这项研究包括36项相关研究。纳入的三项研究未在GWAS目录中列出,强调与已建立的数据库一起进行独立搜索的价值,以确保捕获完整的研究环境。分析了来自25个不同国家的743,919名CAD病例参与者,在这项研究中,61%的研究是在欧洲血统的人群中进行的。除了非裔美国人之外,没有研究调查生活在非洲大陆或混合美国血统的非洲人群体,虽然样本量有限,但除欧洲人和东亚人外,还包括人口群体。这种观察到的不成比例的人口代表性突出了文献中的差距,这限制了我们将冠状动脉疾病理解为全球性疾病的能力。在多篇文章中发现71个与冠状动脉疾病相关的遗传基因座,在每个相应的种群组中鉴定出祖先特定的遗传基因座,而在其他祖先的研究中未检测到。
    结论:尽管这些变体的复制和验证仍然是必要的,这些发现表明了在GWAS参考面板中包括不同祖先群体的价值,可以更全面地了解CAD的遗传结构和病理生理学。
    BACKGROUND: Cardiovascular diseases are some of the leading causes of death worldwide, with coronary artery disease leading as one of the primary causes of mortality in both the developing and developed worlds. Despite its prevalence, there is a disproportionately small number of studies conducted in populations of non-European ancestry, with the limited sample sizes of such studies further restricting the power and generalizability of respective findings. This research aimed at understanding the differences in the genetic architecture of coronary artery disease (CAD) in populations of diverse ancestries in order to contribute towards the understanding of the pathophysiology of coronary artery disease.
    METHODS: We performed a systematic review on the 6th of October, 2022 summarizing genome-wide association studies on coronary artery disease, while employing the GWAS Catalog as an independent database to support the search. We developed a framework to assess the methodological quality of each study. We extracted and grouped associated single nucleotide polymorphisms and genes according to ancestry groups of participants.
    RESULTS: We identified 3100 studies, of which, 36 relevant studies were included in this research. Three of the studies that were included were not listed in the GWAS Catalog, highlighting the value of conducting an independent search alongside established databases in order to ensure the full research landscape has been captured. 743,919 CAD case participants from 25 different countries were analysed, with 61% of the studies identified in this research conducted in populations of European ancestry. No studies investigated populations of Africans living in continental Africa or admixed American ancestry groups besides African-Americans, while limited sample sizes were included of population groups besides Europeans and East Asians. This observed disproportionate population representation highlights the gaps in the literature, which limits our ability to understand coronary artery disease as a global disease. 71 genetic loci were identified to be associated with coronary artery disease in more than one article, with ancestry-specific genetic loci identified in each respective population group which were not detected in studies of other ancestries.
    CONCLUSIONS: Although the replication and validation of these variants are still warranted, these finding are indicative of the value of including diverse ancestry populations in GWAS reference panels, as a more comprehensive understanding of the genetic architecture and pathophysiology of CAD can be achieved.
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  • 文章类型: Review
    目的:本文主张加强范围审查方法,以纳入土著知识方式,being,并为更有效地理解对土著人口重要性的证据。
    方法:范围审查方法通常旨在了解现有证据并支持将证据转化为实践。Levac及其同事(2010)范围审查方法阶段:1)确定研究问题;2)确定相关研究;3)研究选择;4)绘制数据图表;5)整理,总结,和报告结果;6)从土著知识的角度考虑了磋商,并相应地进行了调整。
    结果:增强的方法与基于关系的土著方法更好地保持一致,合作,伙伴关系,互惠,和利益。协商在这一加强中被重新定义为伙伴关系,并在整个范围审查阶段整合,以关键的方法论原则为基础。
    结论:使用土著知识方式增强范围审查阶段,being,和这样做有可能加强范围审查方法的效用,以更好地满足土著人口的需求并确保其相关性。
    结论:这些增强可以增加知识转化的潜力,并将文化相关的循证方法付诸实践,适用于土著居民和其他经历健康不平等的人群。
    OBJECTIVE: This paper argues for the enhancement of scoping review methods to incorporate Indigenous ways of knowing, being, and doing for more effective understandings of evidence of importance to Indigenous populations.
    METHODS: Scoping review methodology typically aims to understand existing evidence and support translation of evidence into practice. Levac and colleagues (2010) scoping review methodology stages: 1) Identify the research question; 2) Identify relevant studies; 3) Study selection; 4) Charting the data; 5) Collating, summarising, and reporting results; and 6) Consultation were considered from the perspective of Indigenous knowledges and adapted accordingly.
    RESULTS: An enhanced method better aligns with Indigenous methodologies which are based on relationality, collaboration, partnership, reciprocity, and benefit. Consultation was redefined in this enhancement as partnership and integrated throughout scoping review stages, which are underpinned by key methodological principles.
    CONCLUSIONS: Enhancement of scoping review stages with Indigenous ways of knowing, being, and doing has the potential to strengthen the utility of scoping review methods to better meet the needs of and ensure relevance for Indigenous populations.
    CONCLUSIONS: These enhancements can increase the potential for knowledge translation and implementation of culturally relevant evidence-based approaches into practice for Indigenous populations and for other populations who experience health inequities.
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