■本研究前瞻性调查了免疫球蛋白G(IgG)N-聚糖性状与缺血性卒中(IS)风险之间的关联。
■在中国次优健康队列研究中进行了嵌套病例对照研究,2013-2014年招募了4,313人。病例被确定为诊断为IS的患者,对照组按年龄和性别与病例1:1匹配。分析基线血浆样品中的IgGN-聚糖。
■共包括99个IS病例和99个对照,和24个直接测量的聚糖峰(GP)与IgGN-聚糖分离。在直接测量的GP中,在调整年龄后,GP4、GP9、GP21、GP22、GP23和GP24与男性的IS风险相关。腰围和臀围,肥胖,糖尿病,高血压,和血脂异常。代表半乳糖基化和唾液酸化降低的衍生聚糖性状与男性IS相关(FBG2S2/(FBG2+FBG2S1+FBG2S2):比值比(OR)=0.92,95%置信区间(CI):0.87-0.97;G1n:OR=0.74,95%CI:0.63-0.87;G0n:OR=1.12-22%CI:1.03。然而,这些关联在女性中没有发现。
■这项研究验证了改变的IgGN-聚糖性状与男性IS事件相关,这表明这些关联中可能存在性别差异。
UNASSIGNED: This study prospectively investigates the association between immunoglobulin G (IgG) N-glycan traits and ischemic stroke (IS) risk.
UNASSIGNED: A nested
case-control study was conducted in the China suboptimal health cohort study, which recruited 4,313 individuals in 2013-2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. IgG N-glycans in baseline plasma samples were analyzed.
UNASSIGNED: A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks (GPs) were separated from IgG N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference, obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men (FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio ( OR) = 0.92, 95% confidence interval ( CI): 0.87-0.97; G1 n: OR = 0.74, 95% CI: 0.63-0.87; G0 n: OR = 1.12, 95% CI: 1.03-1.22). However, these associations were not found among women.
UNASSIGNED: This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.