背景:加巴喷丁,一种广泛用于治疗各种神经性疼痛的药物,已证明在管理各种神经系统疾病方面有效。虽然传统的副作用是有据可查的,越来越多的证据表明存在非典型副作用,需要全面探索。本文旨在系统回顾和总结有关加巴喷丁非典型副作用的文献,在常规光谱之外的表现上发光。
方法:进行了系统评价,包括在2023年11月知识截止日期之前发表的同行评审文章。数据库,特别是PubMed,搜索相关研究,专注于非典型副作用,如肌阵挛症,共济失调,儿科侵略,呼吸抑制,肺炎,妊娠并发症,睡眠干扰,脑病,外周水肿,自杀意念,运动障碍,性高潮,和肌病。纳入标准包括重点研究加巴喷丁相关的非典型副作用,发表在公认的期刊上,涉及人类受试者。
结果:评论确定了一系列与加巴喷丁使用相关的非典型副作用,从神经表现如肌阵鸣和共济失调到行为改变如小儿攻击性和自杀意念。此外,呼吸系统并发症,怀孕相关的问题,睡眠障碍,并观察到罕见的并发症,如脑病和肌病。文献综合提供了对发病率的见解,临床表现,以及这些非典型副作用的潜在机制。
结论:这篇综合综述强调了与加巴喷丁使用相关的各种非典型副作用,超越传统知识。医疗保健从业者必须认识到这些表现,认识到它们对患者健康的潜在影响。由于临床决策依赖于对药物副作用的透彻理解,这项审查有助于提高加巴喷丁处方和管理方面的认识并促进知情实践。需要进一步的研究来阐明与这些非典型副作用相关的机制和风险因素。完善我们对加巴喷丁安全概况的理解。
BACKGROUND: Gabapentin, a widely prescribed medication for various neuropathic pain conditions, has demonstrated efficacy in managing diverse neurological disorders. While conventional side effects are well-documented, a growing body of evidence suggests the existence of atypical side effects, necessitating comprehensive exploration. This paper aims to systematically
review and summarize the literature on the atypical side effects of gabapentin, shedding light on manifestations beyond the conventional spectrum.
METHODS: A systematic
review was conducted, encompassing peer-reviewed articles published up to the knowledge cutoff date in November 2023. Databases, specifically PubMed, were searched for relevant studies, focusing on atypical side effects such as myoclonus, ataxia, pediatric aggression, respiratory depression, pneumonia, pregnancy complications, sleep interference, encephalopathy, peripheral edema, suicidal ideation, dyskinesia, anorgasmia, and myopathy. Inclusion criteria comprised studies with a focus on gabapentin-related atypical side effects, published in recognized journals and involving human subjects.
RESULTS: The
review identified a spectrum of atypical side effects associated with gabapentin use, ranging from neurological manifestations like myoclonus and ataxia to behavioral changes such as pediatric aggression and suicidal ideation. Additionally, respiratory complications, pregnancy-related issues, sleep disturbances, and rare complications like encephalopathy and myopathy were observed. Literature synthesis provided insights into the incidence, clinical presentation, and potential mechanisms underlying these atypical side effects.
CONCLUSIONS: This comprehensive
review highlights the diverse range of atypical side effects associated with gabapentin use, expanding beyond conventional knowledge. Healthcare practitioners must be cognizant of these manifestations, recognizing their potential impact on patient well-being. As clinical decision-making relies on a thorough understanding of a medication\'s side effect profile, this
review contributes to enhancing awareness and fostering informed practices in the prescription and management of gabapentin. Further research is warranted to elucidate the mechanisms and risk factors associated with these atypical side effects, refining our understanding of gabapentin\'s safety profile.