PDF(Pubmed)
Abstract：
Introduction: Polyneuropathy (PNP) is a chronic progressive disease that over time can lead to damage of sensory, motor and/or autonomic peripheral nerves. Symptoms vary from predominantly sensory to severe sensorimotor affection both proximally and distally. This can result in considerable functional impairments that affect activities of daily living. In other neurological patients, strength training has shown to improve strength and functional outcomes. Since medical treatment only exists for very few percentages of the underlying causes it is obvious to consider if strength training could be a potential treatment for functional impairments. To date little is known on the effect of strength training in patients with PNP. Aim: The aim of this scoping review was to summarize research on strength training and outcomes on physical function in patients with PNP. Methods: We systematically searched five data bases; Pubmed, Embase, Cinahl, Cochrane library and Web of science. Studies on strength training (load ≥70% of 1RM) in patients with PNP were included. The search was carried out in November 2022. Results: 362 articles were screened by title and abstract, 101 articles were full text screened. Eight studies were included. Patients with Charcot-Marie-Tooth (CMT), chronic inflammatory polyneuropathy (CIDP) and diabetic polyneuropathy (DPN) were represented in the studies (five RCTs, two case-series, and one cross-over trial). The methodological quality ranged from fair-poor in seven studies, one study reached good quality. Results from the studies indicated that strength training in CMT, CIDP and DPN may improve strength. However, various outcomes were used to evaluate strength training, so direct comparisons were difficult. Discussion: In this scoping review we summarized research on strength training and outcomes evaluated in interventions in patients with PNP. Eight studies were included, they indicated that strength training may be beneficial for patients with PNP. However, due to low methodological strength of most studies a recommendation for patients with PNP cannot be made. Thus, the low number of studies with relatively low quality, where various functional outcomes were used, underscores the importance of future studies to evaluate the effect of strength training on relevant functional outcomes and strength in patients with PNP.
摘要：
简介：多发性神经病（PNP）是一种慢性进行性疾病，随着时间的推移会导致感觉受损，运动和/或自主神经。症状从主要的感觉到严重的感觉运动，无论是近端还是远端。这可能导致影响日常生活活动的相当大的功能损害。在其他神经系统患者中，力量训练已证明可以改善力量和功能结果。由于医学治疗仅存在于很少百分比的根本原因中，因此显然要考虑力量训练是否可以成为功能障碍的潜在治疗方法。迄今为止，对力量训练对PNP患者的影响知之甚少。目的：本范围综述的目的是总结PNP患者的力量训练和身体功能结果的研究。方法：我们系统地搜索了五个数据库；Pubmed，Embase,Cinahl,Cochrane图书馆和WebofScience。包括PNP患者的力量训练（1RM的负荷≥70％）的研究。搜索于2022年11月进行。结果:362篇文章按标题和摘要进行筛选,101篇文章进行了全文筛选。包括8项研究。Charcot-Marie-Tooth（CMT）患者，慢性炎症性多发性神经病（CIDP）和糖尿病性多发性神经病（DPN）在研究中被代表（五个RCT，两个案例系列，和一项交叉审判)。在七项研究中，方法学质量从相当差的水平不等，一项研究达到了良好的质量。研究结果表明，CMT的力量训练，CIDP和DPN可以提高强度。然而,各种结果被用来评估力量训练，所以直接比较很困难。讨论：在这篇范围综述中，我们总结了PNP患者的力量训练和干预效果评估的研究。其中包括8项研究,他们指出力量训练可能对PNP患者有益.然而,由于大多数研究的方法学强度较低,因此无法对PNP患者提出建议.因此，质量相对较低的研究数量少，在使用各种功能结果的地方，强调了未来研究评估力量训练对PNP患者相关功能结局和力量影响的重要性.
