PDF(Pubmed)
Abstract：
Nitrous oxide abuse can have detrimental effects on the central and peripheral nervous systems. This case study report aims to demonstrate a combination of severe generalized sensorimotor polyneuropathy and cervical myelopathy related to vitamin B12 deficiency following nitrous oxide abuse. We present a clinical case study and literature review examining primary research-published between 2012 and 2022-reporting nitrous oxide abuse affecting the spinal cord (myelopathy) and peripheral nerves (polyneuropathy); 35 articles were included in the review with a total of 96 patients, where the mean \"patients\" age was 23.9 years and were in a 2:1 male/female ratio. Of the 96 cases, within the review, 56% of patients were diagnosed with polyneuropathy, most commonly impacting the nerves of the lower limb (62%), while 70% of patients were diagnosed with myelopathy, most commonly impacting the cervical region (78%) on the spinal cord. In our clinical case study, a 28-year-old male underwent a multitude of diagnostic investigations for bilateral \"foot drop\" and sense of lower limb stiffness as ongoing complications of a vitamin B12 deficiency secondary to recreational nitrous oxide abuse. Both the literature review and our case report emphasize the dangers of recreational nitrous oxide inhalation, colloquially termed \"nanging\" and the risks it presents to both the central and peripheral nervous systems, which is erroneously considered by many recreational drug users to be less harmful than other illicit substances.
摘要：
一氧化二氮滥用可对中枢和外周神经系统产生有害影响。本案例研究报告旨在证明一氧化二氮滥用后与维生素B12缺乏相关的严重广泛性感觉运动多发性神经病和脊髓型颈椎病的组合。我们提供了一项临床案例研究和文献综述，审查了2012年至2022年之间发表的主要研究报告，报告了一氧化二氮滥用影响脊髓（脊髓病）和周围神经（多发性神经病）;该综述包括35篇文章，共有96名患者，其中“患者”的平均年龄为23.9岁，男女比例为2:1。在96个案例中，在审查中，56%的患者被诊断为多发性神经病,最常见的是影响下肢神经（62%），70%的患者被诊断为脊髓病，最常见的是影响脊髓的颈部（78%）。在我们的临床案例研究中，一名28岁男性接受了大量双侧"足下垂"和下肢僵硬感的诊断检查,作为娱乐性一氧化二氮滥用继发的维生素B12缺乏的持续并发症.文献综述和我们的病例报告都强调了娱乐性一氧化二氮吸入的危险，通俗地称为“神经”及其对中枢神经系统和周围神经系统的风险，许多娱乐性吸毒者错误地认为这比其他非法药物危害小。
