参与一碳代谢的B族维生素与炎症和血管生成相关的慢性疾病的发展有关。例如结直肠癌(CRC)。然而,单碳代谢在CRC患者炎症和血管生成中的作用尚不清楚.这项研究的目的是在前瞻性ColoCare研究中,在新诊断的CRC患者(n238)中,调查一碳代谢成分与炎症和血管生成生物标志物的关联。海德堡.我们使用多变量线性回归模型从手术前血清样本中横截面分析了十二种B族维生素和一碳代谢物与十种炎症和血管生成生物标志物之间的关联。我们通过Spearman部分相关分析进一步探索了这些途径中新型生物标志物之间的关联。我们假设吡哆醛-5'-磷酸(PLP)与炎症生物标志物呈负相关。我们观察到PLP与C反应蛋白(CRP)呈负相关(r-0·33,P线性<0·0001),血清淀粉样蛋白A(SAA)(r-0·23,P线性=0·003),IL-6(r-0·39,P线性<0·0001),IL-8(r-0·20,P线性=0·02)和TNFα(r-0·12,P线性=0·045)。5-甲基-四氢叶酸和CRP(r-0·14)也观察到类似的发现,CRC患者的SAA(r-0·14)和TNFα(r-0·15)。叶酸分解代谢物乙酰-对氨基苯甲酰基谷氨酸(pABG)与IL-6呈正相关(r0·27,P线性<0·0001),pABG与IL-8呈正相关(r0·21,P线性<0·0001),表明炎症期间叶酸利用率较高。我们的数据支持CRC患者中PLP与炎症生物标志物之间的负相关的假设。更好地了解PLP和其他一碳代谢物与炎症过程在结直肠癌发生和预后中的作用和相互关系,可以确定未来CRC患者饮食指导的目标。
B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and angiogenesis among CRC patients remains unclear. The objective of this
study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed CRC patients (n 238) in the prospective ColoCare
Study, Heidelberg. We cross-sectionally analysed associations between twelve B vitamins and one-carbon metabolites and ten inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesised that pyridoxal-5\'-phosphate (PLP) is inversely associated with inflammatory biomarkers. We observed that PLP was inversely associated with C-reactive protein (CRP) (r -0·33, Plinear < 0·0001), serum amyloid A (SAA) (r -0·23, Plinear = 0·003), IL-6 (r -0·39, Plinear < 0·0001), IL-8 (r -0·20, Plinear = 0·02) and TNFα (r -0·12, Plinear = 0·045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r -0·14), SAA (r -0·14) and TNFα (r -0·15) among CRC patients. Folate catabolite acetyl-para-aminobenzoylglutamic acid (pABG) was positively correlated with IL-6 (r 0·27, Plinear < 0·0001), and pABG was positively correlated with IL-8 (r 0·21, Plinear < 0·0001), indicating higher folate utilisation during inflammation. Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among CRC patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for CRC patients.