早期识别先兆子痫(PE)风险增加的女性是可取的,但除了可溶性fms样酪氨酸激酶-1(sFlt-1),以前很少有生物标志物被鉴定为与预测先兆子痫相关.由于激酶和磷酸酶调节关键的生物过程,并且先前的证据表明这些分子在先兆子痫中的潜在作用,我们进行了系统回顾和元分析.目的是确定是否有激酶和磷酸酶的血清水平在有和没有PE的女性之间不同,是PE的相关生物标志物。我们遵循Cochrane的建议和系统审查和元分析(PRISMA)的首选报告项目进行这项研究。MESH术语先兆子痫,激酶,磷酸酶,血管生成素,可溶性酪氨酸蛋白激酶受体(sTIE2),和细胞-间充质-上皮转化因子(c-MET)相结合,在PubMed中找到相关文章,PROSPERO,和Cochrane数据库。然后,在RStudio软件中进行定性和定量分析.从确定的580篇摘要中,最终分析包括37个,其中包括24,211名孕妇(2879名患有PE的妇女和21,332名没有PE[HP]的妇女。合并分析显示,血清肌酸激酶(CK)(SMD:2.43,CI95%0.25-4.62)在PE中显著增高,而PE的sTIE2和抗血管生成因子可溶性c-Met(sMet)明显低于HP(SMD:-0.23,CI95%-0.37至-0.09;SMD:0.24,CI95%0.01-0.47)。一磷酸腺苷活化蛋白激酶(AMPK),血管生成素-1(ANG-1),血管生成素-2(ANG-2),血管生成素-1/血管生成素-2,酸性磷酸酶,PE和HP女性之间的碱性磷酸酶没有差异。总之,CK,sTIE2和c-MET是PE的相关生物标志物。期望将它们并入用于PE预测的当前模型中以评估它们作为生物标志物的效用。
The early identification of women with an increased risk of preeclampsia (PE) is desirable, but apart from soluble fms-like tyrosine kinase-1 (sFlt-1), few biomarkers have previously been identified as relevant for predicting preeclampsia. Since kinases and phosphatases regulate critical biological processes and previous evidence suggests a potential role of these molecules in preeclampsia, we performed this systematic
review and metanalysis. The objective was to determine if there are kinases and phosphatases whose serum levels are different between women with and without PE, being relevant biomarkers of PE. We followed the recommendations of Cochrane and the Preferred Reported Items for Systematic Reviews and Metanalysis (PRISMA) to perform this study. The MESH terms preeclampsia, kinases, phosphatases, angiopoietins, soluble tyrosine protein kinase receptor (sTIE2), and cellular-mesenchymal-epithelial transition factor (c-MET) were combined to find relevant articles in the PubMed, PROSPERO, and Cochrane databases. Then, a qualitative and quantitative analysis was performed in R Studio software. From 580 abstracts identified, 37 were included in the final analysis, which comprised 24,211 pregnant women (2879 with PE and 21,332 women without PE [HP]. The pooled analysis showed that serum creatine kinase (CK) (SMD: 2.43, CI 95% 0.25-4.62) was significantly higher in PE, whereas sTIE2 and anti-angiogenic factor soluble c-Met (sMet)were significantly lower in PE than in HP (SMD: -0.23, CI95% -0.37 to -0.09; and SMD:0.24, CI95% 0.01-0.47, respectively). Adenosine monophosphate-activated protein kinase (AMPK), angiopoietin-1 (ANG-1), angiopoietin-2 (ANG-2), the ratio angiopoietin-1/angiopoietin-2, acid phosphatase, and alkaline phosphatase were not different between women with PE and HP. In summary CK, sTIE2, and c-MET are relevant biomarkers of PE. It is desirable to incorporate them into current models for PE prediction to evaluate their utility as biomarkers.