虽然许多研究集中在帕金森语音的分段变化,关于反映帕金森病(PwPD)患者适应交际需求的能力的韵律调制知之甚少。这种韵律调制对于社会互动很重要,它涉及语音旋律(语调水平)和辅音和元音(分段水平)的发音。本研究调查了轻度构音障碍PwPD中不同焦点结构的韵律调制的语音线索,作为左旋多巴的函数。在两种运动条件下评估了25PwPD的声学和运动学语音参数。通过3-D电磁关节描记术在左旋多巴摄入之前(药物关闭)和之后(药物打开)收集来自PwPD的语音产生数据。在声学层面上,强度,螺距,和音节持续时间进行了分析。在运动学层面上,运动持续时间和振幅进行了调查。在三种不同的韵律聚焦结构(失焦,广泛关注,对比焦点)以显示不同的语音需求。总的来说,左旋多巴对电机性能有有益的影响,语音响度,和间距调制。声学音节持续时间和运动学运动持续时间没有变化,没有揭示运动状态对时域的系统影响。相比之下,在左旋多巴下,口腔关节有空间调制:舌尖运动较小,下唇运动幅度较大,反映了左旋多巴下更敏捷和有效的关节运动。因此,呼吸发声功能和辅音产生得到改善,而音节持续时间和舌体运动学没有改变。有趣的是,突出标记策略在调查的药物条件之间具有可比性,事实上,似乎保存在轻度构音障碍的PwPD中。
While many studies focus on segmental variation in Parkinsonian speech, little is known about prosodic modulations reflecting the ability to adapt to communicative demands in people with Parkinson\'s disease (PwPD). This type of prosodic modulation is important for social interaction, and it involves modifications in speech melody (intonational level) and articulation of consonants and vowels (segmental level). The present study investigates phonetic cues of prosodic modulations with respect to different focus structures in mild dysarthric PwPD as a function of levodopa. Acoustic and kinematic speech parameters of 25 PwPD were assessed in two motor conditions. Speech production data from PwPD were collected before (medication-OFF) and after levodopa intake (medication-ON) by means of 3-D electromagnetic articulography. On the acoustic level, intensity, pitch, and syllable durations were analyzed. On the kinematic level, movement duration and amplitude were investigated. Spatio-temporal modulations of speech parameters were examined and compared across three different prosodic focus structures (out-of-focus, broad focus, contrastive focus) to display varying speech demands. Overall, levodopa had beneficial effects on motor performance, speech loudness, and pitch modulation. Acoustic syllable durations and kinematic movement durations did not change, revealing no systematic effects of motor status on the temporal domain. In contrast, there were spatial modulations of the oral articulators: tongue tip movements were smaller and lower lip movements were larger in amplitude under levodopa, reflecting a more agile and efficient articulatory movement under levodopa. Thus, respiratory-phonatory functions and consonant production improved, while syllable duration and tongue body kinematics did not change. Interestingly, prominence marking strategies were comparable between the medication conditions under investigation, and in fact, appear to be preserved in mild dysarthric PwPD.