在没有明确诊断的情况下,医疗保健提供者可能会给那些疟疾检测阴性的人开经验性抗菌药物。这个问题在南亚(SA)和东南亚(SEA)至关重要,据报道,这些地区的抗微生物剂消费量高,抗微生物剂耐药性高。为了改善管理并指导进一步的诊断测试开发,需要更好地了解发烧的真正致病因素及其地理变异性。
我们对已发表的文献(1980-2015年)进行了系统综述,以表征导致SA和SEA非疟疾性发热性疾病的病原体谱。我们搜索了六个英文和法文数据库:MEDLINE,EMBASE,全球卫生(CABI)数据库,世卫组织全球卫生图书馆,帕斯卡尔,和法国律师协会公告(BDSP)。选择标准包括报告感染或确诊感染,定义为在正常无菌部位的样品中检测或培养的病原体,或当前或过去感染的血清学证据。
共筛选了来自南非和东南亚19个国家的29,558条记录,其中2410人(8.1%)符合甄选标准。1235(51.2%)篇文章报道了细菌病原学,病毒在846(35.1%),寄生在132(5.5%),和真菌在54(2.2%),143篇(6.0%)文章报告了一个以上的病原体组。按照频率的降序,伤寒沙门氏菌,大肠杆菌,金黄色葡萄球菌,肺炎克雷伯菌,凝固酶阴性葡萄球菌是常见的细菌,而登革热病毒,基孔肯雅病毒,日本脑炎病毒,乙型肝炎病毒,丙型肝炎病毒是常见的病毒病原体。很少报告或新出现的病原体的报告包括2010年印度的伯氏螺旋体(莱姆病)病例报告和新加坡和印度的尼帕病毒报告。
这篇综述总结了报道的可能导致SA和SEA发热性疾病的非疟疾病原体。研究结果强调需要标准化病因学研究的报告,以开发有效的,以证据为基础的发热管理和改善监测。诊断工具的研究和开发将受益于非疟疾发热病因区域多样性的最新流行病学报告。
PROSPERO注册,CRD42016049281。
In the absence of definitive diagnosis, healthcare providers are likely to prescribe empirical antibacterials to those who test negative for malaria. This problem is of critical importance in Southern Asia (SA) and South-eastern Asia (SEA) where high levels of antimicrobial consumption and high prevalence of antimicrobial resistance have been reported. To improve management and guide further diagnostic test development, better understanding is needed of the true causative agents of fever and their geographical variability.
We conducted a systematic
review of published literature (1980-2015) to characterise the spectrum of pathogens causing non-malarial febrile illness in SA and SEA. We searched six databases in English and French languages: MEDLINE, EMBASE, Global Health (CABI) database, WHO Global Health Library, PASCAL, and Bulletin de la Société Française de Parasitologie (BDSP). Selection criteria included reporting on an infection or infections with a confirmed diagnosis, defined as pathogens detected in or cultured from samples from normally sterile sites, or serological evidence of current or past infection.
A total of 29,558 records from 19 countries in SA and SEA were screened, of which 2410 (8.1%) met the selection criteria. Bacterial aetiologies were reported in 1235 (51.2%) articles, viral in 846 (35.1%), parasitic in 132 (5.5%), and fungal in 54 (2.2%), and 143 (6.0%) articles reported more than one pathogen group. In descending order of frequency, Salmonella Typhi, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and coagulase negative Staphylococcus were the commonly reported bacteria, while dengue virus, chikungunya virus, Japanese encephalitis virus, hepatitis B virus, and hepatitis C virus were common viral pathogens reported. Reports of rarely reported or emerging pathogens included a case report of Borrelia burgdorferi (Lyme disease) in India in 2010 and reports of Nipah virus in Singapore and India.
This
review summarises the reported non-malaria pathogens that may cause febrile illness in SA and SEA. The findings emphasise the need of standardising the reporting of aetiological studies to develop effective, evidence-based fever management and improved surveillance. Research and development of diagnostic tools would benefit from up-to-date epidemiological reporting of the regional diversities of non-malaria fever aetiologies.
PROSPERO registration, CRD42016049281.