Oral and maxillofacial surgery

口腔颌面外科
  • 文章类型: Journal Article
    目的和背景口腔颌面外科是一个重要的医学专业,专注于诊断,治疗,预防影响口腔的疾病和伤害,下巴,和脸。在冰雹的特定研究领域中缺乏对该领域的认识。这项研究旨在评估知识,意识,以及医疗保健专业人员和公众对颌面外科的看法。方法本研究包括225名参与者,由牙科和医疗专业人员以及冰雹中的公众组成,沙特阿拉伯。采用了便利采样,参与者需要至少20岁,是冰雹的居民。经过验证的在线问卷,翻译成阿拉伯语,用于数据收集。结果78.2%的牙科专业人员了解口腔颌面外科专业。在普通人群和大多数医疗专业人员中,与颌面外科手术最常见的相关程序是损伤的治疗,骨折,和口腔的形态变化,下巴,和脸,85.8%的参与者报告。此外,60.9%的参与者认为颌面手术是唇裂矫正的适当转诊。结论该研究强调了目标人群中口腔颌面外科医师的作用。在225名参与者中,137名参与者(60.9%)选择了颌面外科专业进行手术干预以治疗唇裂。此外,75.1%(n=169)的参与者以前听说过口腔颌面外科,而24.9%(n=56)的人从未听说过这个专业。调查结果还显示,189名参与者不知道颌面外科医生负责治疗无法使用正畸治疗的严重畸形,如生长障碍,下颌发育不全和发育不全,和下颌的不对称性(下颌的前颌和后颌)。为了弥合这种知识差距,在普通民众和医疗保健专业人员中实施有针对性的教育举措和提高认识运动至关重要。通过提高对口腔颌面外科医生专业作用的认识和理解,患者护理可以优化,并可以确保向这些专家进行适当的转诊。临床意义这项研究表明,提高卫生专业人员和公众对口腔颌面外科的认识非常重要。提高对这一专业的理解可以导致更好的患者结果和早期转诊。
    Aim and background Oral and maxillofacial surgery is a crucial medical specialty focused on diagnosing, treating, and preventing diseases and injuries affecting the oral cavity, jaw, and face. There is a lack of awareness about this field in the specific study area of hail. This study aimed to assess the knowledge, awareness, and perception of maxillofacial surgery among healthcare professionals and the public. Methods The study included 225 participants, consisting of dental and medical professionals and the general public in Hail, Saudi Arabia. Convenience sampling was employed, and participants needed to be at least 20 years old and residents of Hail. A validated online questionnaire, translated into Arabic, was used for data collection. Results A proportion (78.2%) of dental professionals were aware of the specialty of oral and maxillofacial surgery. Among the general population and most medical professionals, the most commonly associated procedures with maxillofacial surgery were the treatment of injuries, bone fractures, and morphological changes in the mouth, jaw, and face, reported by 85.8% of the participants. Furthermore, 60.9% of the participants believed that maxillofacial surgery was the appropriate referral for cleft lip correction. Conclusion The study highlighted significant knowledge about the role of oral and maxillofacial surgeons among the target population. Out of the 225 participants, 137 participants (60.9%) chose the specialty of maxillofacial surgery for surgical intervention to treat cleft lips. Moreover, 75.1% (n = 169) of the participants had previously heard about oral and maxillofacial surgery, while 24.9% (n = 56) had never heard of this specialty. The findings also showed that 189 participants were not aware that a maxillofacial surgeon is responsible for treating severe deformities that cannot be eliminated using orthodontics, such as growth disorders, hypoplasia and hypoplasia of the lower jaw, and asymmetry of the lower jaw (prognathism and retrognathism of the jaw). To bridge this knowledge gap, it is crucial to implement targeted educational initiatives and awareness campaigns among both the general population and healthcare professionals. By increasing awareness and understanding of the specialized role of oral and maxillofacial surgeons, patient care can be optimized, and appropriate referrals to these specialists can be ensured. Clinical significance This study shows the importance of increasing awareness of oral and maxillofacial surgery among health professionals and the general public. Improved understanding of this specialty can lead to better patient outcomes and early referrals.
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  • 文章类型: Journal Article
    背景/目标:自成立以来,尸体模型一直是全球牙科和医学教育的支柱。在澳大利亚,牙科学校的教育工作者是最早在口腔外科的正式教学中使用尸体猪头的人之一。此后,这种做法在大多数现代牙科课程中都不受欢迎。这项初步研究的目的是从学生的角度确定尸体猪模型在口腔外科培训中的实用性(格里菲斯大学,黄金海岸,澳大利亚)。方法:30名所有三年级牙科学生的参与者参加了两个小时的会议,其中包括30分钟的讲座,然后是90分钟的实践研讨会。讲座概述了学生在实践过程中的步骤和监督,并由颌面外科顾问提供。在研讨会结束时,参与者被要求匿名填写一份打印的问卷,其中有8个与他们的经历相关的问题.结果:在研讨会之前,三分之二(61%)的参与者认为他们在第三年的牙科学校课程中被教导过适当提高粘膜骨膜皮瓣的外科手术,尽管只有43%的学生协助专业住院医师举起粘膜骨膜皮瓣,而14%的学生报告自己进行了手术。几乎所有学生(96%)都同意猪模型对他们的牙科教育很有用,如果有机会,他们将再次使用该模型进行练习。问卷的完成率为93.33%。结论:这项初步研究表明,猪头呈现出一种有用的,学习基本口腔外科手术的低成本辅助手段。
    Background/Objectives: Cadaveric models have traditionally been a mainstay of dental and medical education worldwide since their inception. In Australia, educators at dental schools were among the first to use cadaveric porcine heads in formal teaching in oral surgery. This practice has since fallen out of favour in most modern dental curricula. The aim of this pilot study was to determine the utility of cadaveric porcine models for oral surgery training from a student perspective (Griffith University, Gold Coast, Australia). Methods: Thirty participants who were all third-year dental students attended a two-hour session comprising a 30 min lecture followed by a 90 min practical workshop. The lecture outlined the steps and supervision of students during the practical and was provided by a consultant maxillofacial surgeon. At the conclusion of the workshop, participants were asked to anonymously complete a printed questionnaire with eight questions related to their experience. Results: Prior to the workshop, two-thirds (61%) of participants felt that they had been taught the surgical procedure for raising mucoperiosteal flaps adequately in their dental school curriculum during their third year, although only 43% of students had assisted specialty residents in raising a mucoperiosteal flap and 14% reported having performed the procedure themselves. Almost all students (96%) agreed that the porcine model was useful for their dental education and that they would practice the exercise using the model again if provided with the opportunity. The questionnaire had a 93.33% completion rate. Conclusions: This pilot study indicates that porcine heads present a useful, low-cost adjunct in the learning of basic oral surgical procedures.
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  • 文章类型: Journal Article
    下颌前区的外科手术需要对复杂的解剖结构有深刻的了解,以确保患者的安全。舌孔(LF)及其骨内管是关键结构,为精神区域提供血管和神经支持。LF的患病率被广泛认可,人口之间的差异。
    该研究涉及650名成年参与者。使用高分辨率锥形束计算机断层扫描(CBCT)收集数据,并进行了统计分析,建立评分者之间的协议。
    人口有不同的年龄分布,男性占53.23%,女性占46.77%。正中舌管见于上、下(65.38%)。大多数参与者有舌侧管(60.92%)。最普遍的舌孔为4(30.62%)。研究发现性别与LF直径之间没有显着关联,分布在不同的行进方向,或LF位置。然而,雄性的直径稍大。
    这些发现为基于解剖位置的LF变化提供了有价值的见解,不同年龄组的测量结果无统计学显著差异.这些知识有助于口腔颌面外科领域的发展,确保更好的患者结果。
    UNASSIGNED: Surgical procedures in the anterior mandibular region require a profound understanding of the complex anatomical structures to ensure patient safety. The lingual foramen (LF) and its intra-osseous canal are pivotal structures, supplying vascular and neural support to the mental region. The prevalence of LF is widely recognized, with variations among populations.
    UNASSIGNED: The study involved 650 adult participants. Data were collected using high-resolution cone-beam computed tomography (CBCT), and statistical analysis was conducted, establishing inter-rater agreement.
    UNASSIGNED: The population had a varied age distribution, with males comprising 53.23% and females comprising 46.77%. The median lingual canal was found in the Supra and Infra spinosum (65.38%). Most participants had lateral lingual canals (60.92%). The most prevalent lingual foramina was 4 (30.62%). The study found no significant associations between gender and LF diameter, distribution in different travel directions, or LF locations. However, males had a slightly larger diameter.
    UNASSIGNED: The findings provide valuable insights into LF variations based on anatomical locations, and there were no statistically significant differences in measurements across different age groups. This knowledge contributes to the evolving field of oral and maxillofacial surgery, ensuring better patient outcomes.
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  • 文章类型: Journal Article
    钛仍然是骨接合材料领域的黄金标准。这也适用于小儿颅面手术。已经开发了各种可再吸收材料,以避免昂贵且有风险的二次操作来去除儿童中的金属。然而,这些可吸收材料都不能完全取代以前的黄金标准,钛,以令人满意的方式。这导致了对满足生物相容性要求的新型可再吸收骨合成材料的需求。稳定性,和均匀的再吸收。在我们之前的体外和体内工作中,我们能够证明钼满足了这些要求。为了进一步证实这些结果,我们对四头家猪进行了概念验证,每个都植入了可吸收的钼植入物。然后每天检查动物的局部炎症参数。54天后,随后用计算机断层扫描成像对动物实施安乐死。我们还切除了植入物以及周围的组织和部分脾脏,肝脏,和肾脏进行组织病理学评估。钼植入物也进行了金相分析和使用扫描电子显微镜。在手术前和手术后采集血样。在整个测试期间,没有动物显示出炎症的临床症状。组织病理学,发现了良好的组织相容性。54天后观察到降解的早期迹象,不足以进行大量吸收。根据类似的早期调查的结果,预计再吸收将具有更长的原位停留时间。
    Titanium continues to be the gold standard in the field of osteosynthesis materials. This also applies to pediatric craniofacial surgery. Various resorbable materials have already been developed in order to avoid costly and risky second operations to remove metal in children. However, none of these resorbable materials have been able to completely replace the previous gold standard, titanium, in a satisfactory manner. This has led to the need for a new resorbable osteosynthesis material that fulfills the requirements for biocompatibility, stability, and uniform resorption. In our previous in vitro and in vivo work, we were able to show that molybdenum fulfills these requirements. To further confirm these results, we conducted a proof of concept in four domestic pigs, each of which was implanted with a resorbable molybdenum implant. The animals were then examined daily for local inflammatory parameters. After 54 days, the animals were euthanized with subsequent computer tomography imaging. We also removed the implants together with the surrounding tissue and parts of the spleen, liver, and kidney for histopathological evaluation. The molybdenum implants were also analyzed metallographically and using scanning electron microscopy. A blood sample was taken pre- and post-operatively. None of the animals showed clinical signs of inflammation over the entire test period. Histopathologically, good tissue compatibility was found. Early signs of degradation were observed after 54 days, which were not sufficient for major resorption. Resorption is expected with longer in situ residence times based on results of similar earlier investigations.
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  • 文章类型: Journal Article
    印度牙科委员会已将面部整形手术纳入印度口腔颌面外科(OMFSs)的实践范围。然而,这些专家对面部整形手术的知识和兴趣尚未探索。
    在印度注册的OMFSs中分发了一项描述性横断面研究,该研究由具有六个领域和46个问题的结构化问卷工具组成。该研究由950名参与者组成。将从该问卷中获得的数据进行编码并输入到社会科学统计软件包(SPSS)中,并进行了描述性分析。
    该研究表明,只有33%的参与者完全意识到面部填充物,而30.5%的参与者意识到肉毒杆菌毒素的程序。然而,42%的人完全意识到眼睑成形术,唇形成形术/腭成形术占65.8%,23.7%的参与者进行激光面部修复,23.5%的参与者进行面部年轻化。
    发现大量的OMFSs认为他们在毕业后的几年中接受整形手术是不够的。
    UNASSIGNED: The Dental Council of India has included facial plastic surgery in the scope of practice of Oral and Maxillofacial Surgeons (OMFSs) in India. However, the knowledge and interests of these specialists towards facial plastic surgery are unexplored.
    UNASSIGNED: A descriptive cross-sectional study consisting of a structured questionnaire tool with six domains and 46 questions was circulated amongst registered OMFSs in India. The study consisted of 950 participants. The data obtained from this questionnaire were coded and entered into Statistical Package for Social Sciences (SPSS) and a descriptive analysis was conducted.
    UNASSIGNED: The study yielded that only 33% of the participants were completely aware of facial fillers and 30.5% were aware of Botox procedure. However, there was complete awareness of blepharoplasty in 42%, cheiloplasty/palatoplasty in 65.8%, laser facial resurfacing in 23.7% and facial rejuvenation in 23.5% of the participants.
    UNASSIGNED: It was found that a high number of OMFSs felt that their exposure to plastic surgery during their post-graduation years was not sufficient.
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  • 文章类型: Journal Article
    在英格兰的医院中进行手术摘除术的数量尚不清楚。这项研究报告了在COVID-19大流行期间在医院进行的手术摘除术的数量和活动的变化。
    我们在2015年4月1日至2020年12月31日期间,使用英格兰医院事件统计(HES)对接受手术拔除牙齿(使用OPSC-4代码F09定义)的患者进行了一项全国性观察性队列研究。程序按年龄分层,性别,和紧迫性(选修或非选修),使用描述性统计数据报告,number,和百分比。我们进行了事后建模,以预测到2023年12月的手术活动。此外,我们将其与有关简单的拔牙程序,医院中的牙脓肿引流以及一般实践中的牙科活动的国家汇总数据进行了对比。
    我们确定了手术切除牙齿的总共569,938次发作(女性占57%)。其中,493,056/569,938(87%)为成人,76,882/569,938(13%)为≤18岁的儿童。手术拔除在成年女性中最常见。择期病例占手术的96%(n=548,805/569,938)。在COVID-19大流行期间,每季度进行的手术数量中位数为27,256例,降至12,003例,代表活动减少56%。这相当于约61058个取消的程序。建模预测该活动尚未恢复到流行前水平。
    在大流行期间,医院进行的外科手术数量下降了56%。这种减少的真正影响是未知的,但是延迟治疗会增加并发症的风险,包括危及生命的感染.
    这项研究的结果提供了一个基于证据的概述,概述了英格兰在医院进行的手术拔牙的趋势。此信息可用于告知服务和劳动力计划,以满足需要手术摘除的患者的需求。这些数据还提供了对英格兰人口口腔健康需求的见解。
    UNASSIGNED: The number of surgical extractions performed in hospitals in England remains unclear. This study reports the volume of surgical extractions conducted in hospitals and change in activity during the COVID-19 pandemic.
    UNASSIGNED: We conducted a nationwide observational cohort study using Hospital Episode Statistics (HES) in England for patients undergoing surgical removal of a tooth (defined using OPSC-4 code F09) between April 1, 2015, and December 31, 2020. Procedures were stratified by age, gender, and urgency (elective or nonelective), reported using descriptive statistics, number, and percentage. We conducted post hoc modeling to predict surgical activity to December 2023. In addition, we contrasted this with aggregate national data on simple dental extraction procedures and drainage of dental abscesses in hospital as well as dental activity in general practice.
    UNASSIGNED: We identified a total of 569,938 episodes for the surgical removal of a tooth (females 57%). Of these, 493,056/569,938 (87%) were for adults and 76,882/569,938 (13%) children ≤18 years. Surgical extractions were most frequent in adult females. Elective cases accounted for 96% (n = 548,805/569,938) of procedures. The median number of procedures carried out per quarter was 27,256, dropping to 12,003 during the COVID-19 pandemic, representing a 56% reduction in activity. This amounted to around 61,058 cancelled procedures. Modeling predicts that this activity has not returned to prepandemic levels.
    UNASSIGNED: The number of surgical extractions taking place in hospitals during the pandemic fell by 56%. The true impact of this reduction is unknown, but delayed treatment increases the risk of complications, including life-threatening infections.
    UNASSIGNED: The result of this study provides an evidence-based overview of the trends relating to surgical extractions of teeth in England taking place in hospitals. This information can be used to inform service and workforce planning to meet the needs of patients requiring surgical extractions. The data also provide an insight into the oral health needs of the population in England.
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  • 文章类型: Journal Article
    尽管对颌骨骨髓炎(OMJ)的诊断和治疗有了更多的了解,它仍然是口腔颌面外科医师的临床挑战。这项研究旨在确定与严重形式的OMJ相关的危险因素,即,与主要并发症的发生或疾病的难治性过程有关。根据过去20年诊断为OMJ的所有患者的医疗记录进行了回顾性研究。收集的数据包括人口统计信息,医疗和牙科史,临床,放射学,和细菌的发现以及治疗方式。主要结果变量是主要并发症的发生和治疗结果。包括54名患者。我们的结果表明,酒精和吸烟习惯,以及营养不良,与主要并发症的发生显著相关。我们还确定,牙科植入物诱导的OMJ应被视为OMJ的侵袭性亚型。最后,临床骨暴露与不良结局显著相关,而牙科原因或骨膜反应的放射学证据可预测成功的结局。确定这些因素可能有助于预防严重的并发症,并根据这些因素的存在告知患者疾病的难治性病程。
    Despite improved knowledge regarding the diagnosis and treatment of osteomyelitis of the jaw (OMJ), it remains a clinical challenge for oral and maxillofacial surgeons. This study aimed to identify risk factors associated with severe forms of OMJ, i.e., related to the occurrence of major complications or the refractory course of the disease. A retrospective study was performed based on the medical records of all patients diagnosed with OMJ from the past 20 years. Collected data included demographic information, medical and dental history, clinical, radiological, and bacterial findings as well as treatment modalities. The main outcome variables were the onset of major complications and treatment results. Fifty-four patients were included. Our results showed that alcohol and smoking habits, as well as malnutrition, were significantly associated with the occurrence of major complications. We also established that dental implant-induced OMJ should be considered an aggressive subtype of OMJ. Finally, clinical bone exposure was significantly associated with unfavorable outcomes, whereas dental causes or radiological evidence of periosteal reaction were predictive of successful outcomes. Identifying such factors could be useful in preventing serious complications and informing patients about the refractory course of the disease based on the presence of these factors.
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  • 文章类型: Journal Article
    目的:基质金属蛋白酶是参与多种炎症反应的酶,在多种病理状态下已被作为生物标志物。使用漱口水护理点测试(POCT)检测活性基质金属蛋白酶-8(aMMP-8)已成为牙周炎和其他全身性炎症状态的诊断标记。这项初步研究的目的是评估aMMP-8POCT在口腔颌面外科诊所的适用性,并评估aMMP-8水平与不同患者组之间的关系。
    方法:aMMP-8POCT样本是从口腔颌面外科诊所的患者中收集的,为期一个月。使用椅旁侧流免疫检测和数字阅读器分析aMMP-8水平。收集临床相关的患者变量并进行描述性评估。超过20ng/ml的aMMP-8水平被认为是升高的。
    结果:共采访了115名患者,其中112名患者同意该测试(97.4%)。在58例(51.8%)患者中观察到aMMP-8水平升高。75例(67.0%)患者出现骨丢失。在这些病人中,47例(62.7%)患者的aMMP-8水平升高。与以前没有疾病的患者相比,感染风险增加的患者的aMMP-8值平均高出35.5%。
    结论:aMMP-8POCT提供了一种非侵入性和可靠的测量aMMP-8水平的方法。未来的研究有必要评估aMMP-8水平升高与特定患者组之间的临床相关性。
    结论:测试评分的快速可用性可以立即影响治疗计划。
    OBJECTIVE: Matrix metalloproteinases are enzymes that participate in numerous inflammatory responses and have been targeted as biomarkers in numerous pathologic states. The detection of active matrix metalloproteinase-8 (aMMP-8) using a mouthrinse point-of-care test (POCT) has emerged as a diagnostic marker for periodontitis and other systemic inflammatory states. The objective of this pilot study was to assess the applicability of aMMP-8 POCT in an oral and maxillofacial surgery clinic and to evaluate the relationship between aMMP-8 levels and different patient groups.
    METHODS: aMMP-8 POCT samples were collected from patients in an oral and maxillofacial surgery clinic during a one-month period. aMMP-8 levels were analyzed using a chairside lateral-flow immunotest and a digital reader. Clinically relevant patient variables were collected and descriptively evaluated. aMMP-8 levels over 20 ng/ml were considered to be elevated.
    RESULTS: A total of 115 patients were interviewed of which 112 agreed to the test (97.4%). Elevated aMMP-8 levels were observed in 58 (51.8%) patients. Bone loss was noted in 75 (67.0%) patients. Of these patients, aMMP-8 levels were elevated in 47 (62.7%) patients. Patients at an increased risk of infection had 35.5% higher aMMP-8 values on average compared to patients with no prior illnesses.
    CONCLUSIONS: aMMP-8 POCT provides a non-invasive and reliable method for measuring aMMP-8 levels. Future studies are warranted to assess the clinical relevance between elevated aMMP-8 levels and specific patient groups.
    CONCLUSIONS: The rapid availability of the test score allows an immediate impact on treatment planning.
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  • 文章类型: Journal Article
    口腔颌面外科(OMFS)是最新建立的医学专业之一,其全部范围尚未被其他专业完全了解。本研究的目的是记录希腊国家卫生局的全科医生(GMPs)对OMFS范围的看法。通过结构化问卷对GMPs进行了横断面研究。问题涉及各种头颈部疾病以及可能的参考医学专业。本研究包括66份问卷。参与者建立了区域卫生实践,健康中心或医院。77.2%的参与者会将面部裂伤转介给整形外科医生,只有7.2%的人会转介给OMFS。89.3%的人将zy骨骨折转归OMFS,10.6%的人将ENT转归。绝大多数人会提到舌癌,耳鼻喉科的颈部肿块和口腔病变(74.8%,81.8%,分别为48%)。OMFS对GMPs的范围意识可以被认为较低。因此,在初级医学从业者中扩大OMFS实践的知识非常重要。医学生尽早接触该专业可能是实现这一目标的有效选择。
    Oral and Maxillofacial Surgery (OMFS) is among the newest established medical specialties and its full scope is not fully known by other specialties. The aim of the present study is to record the perception of OMFS scope by general medical practitioners (GMPs) of the National Health Service in Greece. A cross-sectional study was conducted in GMPs via a structured questionnaire. Questions involved various head and neck disorders and possible referring medical specialties. 66 answered questionnaires were included in this study. Participants were established to regional health practices, health centres or hospitals. 77.2% of the participants would refer a facial laceration to a plastic surgeon and only 7.2% to an OMFS. 89.3% would refer a zygoma fracture to an OMFS and 10.6% to an ENT. The vast majority would refer a tongue cancer, a neck mass and a mouth lesion to an ENT (74.8%, 81.8%, and 48% respectively). OMFS scope awareness of GMPs can be considered low. Thus, widening the knowledge of OMFS practice in primary grade medical practitioners is of high importance. Early exposure of medical students to the specialty could be a valid option to achieve this target.
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  • 文章类型: Randomized Controlled Trial
    未经批准:随着成瘾率和阿片类药物死亡人数的增加,医疗保健提供者有义务帮助遏制阿片类药物危机。由于有限的研究检查了固定剂量联合非阿片类镇痛与含阿片类镇痛的比较有效性,通过进行一项试点研究,计划并完善了一项比较有效性研究。
    未经批准:阿片类镇痛药减少研究(OARS)试点,一个分层的,随机化,多站点,双盲临床试验,旨在测试完整OARS试验中使用的技术和程序。参与完整协议的参与者,支持收集OARS结果数据。根据生物学性别对5个部位中的1个进行部分或全部骨性下颌第三磨牙拔除的合格参与者进行分层,并随机分为2个治疗组中的1个。阿片类或非阿片类。向OPIOID参与者提供20剂量的氢可酮5mg/对乙酰氨基酚300mg。向非阿片类药物参与者提供20剂布洛芬400mg/对乙酰氨基酚500mg。OARS结果数据,包括疼痛经历,不利影响,睡眠质量,疼痛干扰,总体满意度,剩余的阿片类药物片剂可用于转移,是通过调查收集的,电子药瓶,eDiary,和活动/睡眠监视器。
    UNASSIGNED:53名参与者被随机分配,其中50名参与者完成了OARS试验方案。在所有结果疼痛领域,除了1个时间段,非阿片类药物在疼痛管理方面优于阿片类药物(P<0.05)。其他结果表明疼痛干扰较少,减少不良事件,更好的睡眠质量,总体满意度较好,更少的含阿片类药物的片剂可用于转移。
    UNASSIGNED:结果表明,需要下颌阻生第三磨牙拔除的患者将受益于固定剂量组合非阿片类镇痛。
    UNASSIGNED:研究结果表明,固定剂量非阿片类药物组合布洛芬400mg/对乙酰氨基酚500mg优于含阿片类药物的镇痛药(氢可酮5mg/对乙酰氨基酚500mg)。这些知识应告知外科医生和患者选择术后镇痛。
    With addiction rates and opioid deaths increasing, health care providers are obligated to help stem the opioid crisis. As limited studies examine the comparative effectiveness of fixed-dose combination nonopioid analgesia to opioid-containing analgesia, a comparative effectiveness study was planned and refined by conducting a pilot study.
    The Opioid Analgesic Reduction Study (OARS) pilot, a stratified, randomized, multisite, double-blind clinical trial, was designed to test technology and procedures to be used in the full OARS trial. Participants engaged in the full protocol, enabling the collection of OARS outcome data. Eligible participants reporting to 1 of 5 sites for partial or full bony impacted mandibular third molar extraction were stratified by biologic sex and randomized to 1 of 2 treatment groups, OPIOID or NONOPIOID. OPIOID participants were provided 20 doses of hydrocodone 5 mg/acetaminophen 300 mg. NONOPIOID participants were provided 20 doses of ibuprofen 400 mg/acetaminophen 500 mg. OARS outcomes data, including pain experience, adverse effects, sleep quality, pain interference, overall satisfaction, and remaining opioid tablets available for diversion, were collected via surveys, electronic medication bottles, eDiary, and activity/sleep monitor.
    Fifty-three participants were randomized with 50 completing the OARS pilot protocol. Across all outcome pain domains, in all but 1 time period, NONOPIOID was better in managing pain than OPIOID (P < 0.05 level). Other outcomes suggest less pain interference, less adverse events, better sleep quality, better overall satisfaction, and fewer opioid-containing tablets available for diversion.
    Results suggest patients requiring impacted mandibular third molar extraction would benefit from fixed-dose combination nonopioid analgesia.
    Study results suggest fixed-dose nonopioid combination ibuprofen 400 mg/acetaminophen 500 mg is superior to opioid-containing analgesic (hydrocodone 5 mg/acetaminophen 500 mg). This knowledge should inform surgeons and patients in the selection of postsurgical analgesia.
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