PDF(Pubmed)
Abstract：
OBJECTIVE: Matrix metalloproteinases are enzymes that participate in numerous inflammatory responses and have been targeted as biomarkers in numerous pathologic states. The detection of active matrix metalloproteinase-8 (aMMP-8) using a mouthrinse point-of-care test (POCT) has emerged as a diagnostic marker for periodontitis and other systemic inflammatory states. The objective of this pilot study was to assess the applicability of aMMP-8 POCT in an oral and maxillofacial surgery clinic and to evaluate the relationship between aMMP-8 levels and different patient groups.
METHODS: aMMP-8 POCT samples were collected from patients in an oral and maxillofacial surgery clinic during a one-month period. aMMP-8 levels were analyzed using a chairside lateral-flow immunotest and a digital reader. Clinically relevant patient variables were collected and descriptively evaluated. aMMP-8 levels over 20 ng/ml were considered to be elevated.
RESULTS: A total of 115 patients were interviewed of which 112 agreed to the test (97.4%). Elevated aMMP-8 levels were observed in 58 (51.8%) patients. Bone loss was noted in 75 (67.0%) patients. Of these patients, aMMP-8 levels were elevated in 47 (62.7%) patients. Patients at an increased risk of infection had 35.5% higher aMMP-8 values on average compared to patients with no prior illnesses.
CONCLUSIONS: aMMP-8 POCT provides a non-invasive and reliable method for measuring aMMP-8 levels. Future studies are warranted to assess the clinical relevance between elevated aMMP-8 levels and specific patient groups.
CONCLUSIONS: The rapid availability of the test score allows an immediate impact on treatment planning.
METHODS: aMMP-8 POCT samples were collected from patients in an oral and maxillofacial surgery clinic during a one-month period. aMMP-8 levels were analyzed using a chairside lateral-flow immunotest and a digital reader. Clinically relevant patient variables were collected and descriptively evaluated. aMMP-8 levels over 20 ng/ml were considered to be elevated.
RESULTS: A total of 115 patients were interviewed of which 112 agreed to the test (97.4%). Elevated aMMP-8 levels were observed in 58 (51.8%) patients. Bone loss was noted in 75 (67.0%) patients. Of these patients, aMMP-8 levels were elevated in 47 (62.7%) patients. Patients at an increased risk of infection had 35.5% higher aMMP-8 values on average compared to patients with no prior illnesses.
CONCLUSIONS: aMMP-8 POCT provides a non-invasive and reliable method for measuring aMMP-8 levels. Future studies are warranted to assess the clinical relevance between elevated aMMP-8 levels and specific patient groups.
CONCLUSIONS: The rapid availability of the test score allows an immediate impact on treatment planning.
摘要：
目的：基质金属蛋白酶是参与多种炎症反应的酶，在多种病理状态下已被作为生物标志物。使用漱口水护理点测试（POCT）检测活性基质金属蛋白酶-8（aMMP-8）已成为牙周炎和其他全身性炎症状态的诊断标记。这项初步研究的目的是评估aMMP-8POCT在口腔颌面外科诊所的适用性，并评估aMMP-8水平与不同患者组之间的关系。
方法：aMMP-8POCT样本是从口腔颌面外科诊所的患者中收集的，为期一个月。使用椅旁侧流免疫检测和数字阅读器分析aMMP-8水平。收集临床相关的患者变量并进行描述性评估。超过20ng/ml的aMMP-8水平被认为是升高的。
结果：共采访了115名患者，其中112名患者同意该测试（97.4%）。在58例(51.8%)患者中观察到aMMP-8水平升高。75例（67.0%）患者出现骨丢失。在这些病人中,47例(62.7%)患者的aMMP-8水平升高。与以前没有疾病的患者相比，感染风险增加的患者的aMMP-8值平均高出35.5％。
结论：aMMP-8POCT提供了一种非侵入性和可靠的测量aMMP-8水平的方法。未来的研究有必要评估aMMP-8水平升高与特定患者组之间的临床相关性。
结论：测试评分的快速可用性可以立即影响治疗计划。
方法：aMMP-8POCT样本是从口腔颌面外科诊所的患者中收集的，为期一个月。使用椅旁侧流免疫检测和数字阅读器分析aMMP-8水平。收集临床相关的患者变量并进行描述性评估。超过20ng/ml的aMMP-8水平被认为是升高的。
结果：共采访了115名患者，其中112名患者同意该测试（97.4%）。在58例(51.8%)患者中观察到aMMP-8水平升高。75例（67.0%）患者出现骨丢失。在这些病人中,47例(62.7%)患者的aMMP-8水平升高。与以前没有疾病的患者相比，感染风险增加的患者的aMMP-8值平均高出35.5％。
结论：aMMP-8POCT提供了一种非侵入性和可靠的测量aMMP-8水平的方法。未来的研究有必要评估aMMP-8水平升高与特定患者组之间的临床相关性。
结论：测试评分的快速可用性可以立即影响治疗计划。
