一只5岁绝育的韩国家养短猫被诊断患有口腔鳞状细胞癌(SCC),因严重的口腔脓性分泌物被送往医院,厌食症,和嗜睡。由于广泛的病变,手术切除和放射治疗不可行。相反,在用托卡尼布进行节拍治疗之前,患者接受静脉注射猫脐带间充质干细胞(fUC-MSCs)(1×106个细胞/10mL生理盐水)以减轻炎症.无急性副作用(如发热,呼吸频率增加,腹泻,和呕吐)在干细胞治疗后观察到。6天,脓性分泌物,出血,肿胀,难闻的气味,面部肿瘤区域的外皮脱落大大减少。然而,患者在自愿接受食物方面表现出困难,和减肥持续。从第七天开始,脓性分泌物,出血,SCC区域的气味再次恶化。Toceranib,低剂量NSAIDs(美洛昔康,每隔一天),抗生素(头孢唑啉),和加巴喷丁服用;然而,它们不能有效减少脓液,出血,恶臭,以及SCC区域的地壳剥落。疼痛的症状,弱点,减肥进展,导致在大约1个月后经业主同意选择安乐死。该病例报告显示,同种异体fUC-MSCs对脓性放电有轻微的短期影响,出血,气味,和外壳脱落,可能是猫口腔SCC的额外疗法。
A 5-year-old neutered female Korean domestic shorthair cat diagnosed with oral squamous cell carcinoma (SCC) presented to the hospital with severe oral purulent discharge, anorexia, and lethargy. Owing to extensive lesions, surgical excision and radiation therapy were not feasible. Instead, prior to metronomic therapy with toceranib, the patient received an intravenous injection of feline umbilical cord-derived mesenchymal stem cells (fUC-MSCs) (1 × 106 cells/10 mL of saline) to reduce inflammation. No acute side effects (such as fever, increased respiratory rate, diarrhea, and vomiting) were observed following stem cell therapy. For 6 days, purulent discharge, bleeding, swelling, a bad odor, and crust exfoliation in the tumor area on the face were dramatically reduced. However, the patient exhibited difficulty in voluntarily receiving foods, and weight loss persisted. Starting from the 7th day, purulent discharge, bleeding, and odor at the SCC area worsened again. Toceranib, low-dose NSAIDs (meloxicam, every other day), antibiotics (cefazoline), and gabapentin were administered; however, they were not effective in reducing the pus, bleeding, foul odor, and crust exfoliation at the SCC area. Symptoms of pain, weakness, and weight loss progressed, leading to the choice of euthanasia with the owner\'s consent approximately 1 month later. This
case report reveals that allogeneic fUC-MSCs have a slight short-term effect on purulent discharge, bleeding, odor, and crust exfoliation and may be additional therapy for feline oral SCC.