PDF(Pubmed)
Abstract：
We systematically reviewed the literature on the co-occurrence of squamous cell carcinoma (SCC) and Warthin\'s tumor (WT), thought to be quite rare, to help reduce misdiagnosis and improve treatment planning. For this systematic review, we searched for articles in the Web of Science and PubMed databases, analyzed relevant studies for forward and backward citations, and identified only articles reporting on the \"co-occurrence\" of WT and SCC. Of the 237 studies identified, 12 comprising 18 patients met the inclusion criteria, to which we added one study from our institution. Most WTs were associated with SCC in the parotid gland or cervical lymph nodes. Most patients (89.5%) underwent selective or radical neck dissection due to identification of lesions separate from the primary SCC. Despite its frequent co-occurrence with other neoplasms, WT in the parotid or cervical lymph nodes tends to be misdiagnosed as a metastatic node when SCC is observed as the primary tumor. Factors to consider in diagnosis and neck management include identification of an association other than growth or development by lymphangiogenesis and whether the patient is a smoker, a strong risk factor.
摘要：
我们系统地回顾了有关鳞状细胞癌（SCC）和Warthin's肿瘤（WT）同时发生的文献，被认为是相当罕见的，帮助减少误诊并改善治疗计划。对于这项系统审查，我们在WebofScience和PubMed数据库中搜索了文章，分析了正向和反向引用的相关研究，并仅确定了报告WT和SCC“共现”的文章。在确定的237项研究中，包括18例患者在内的12例符合纳入标准，我们增加了我们机构的一项研究。大多数WT与腮腺或颈部淋巴结中的SCC有关。由于识别出与原发性SCC分开的病变，大多数患者（89.5％）进行了选择性或根治性颈清扫术。尽管它经常与其他肿瘤同时发生，当将SCC观察为原发性肿瘤时，腮腺或颈淋巴结中的WT往往被误诊为转移淋巴结。诊断和颈部管理中需要考虑的因素包括确定淋巴管生成引起的生长或发育以外的关联，以及患者是否是吸烟者，一个强大的风险因素。
