Abstract：
Oral squamous cell carcinoma (OSCC) with metastasis to the thyroid gland is exceedingly rare, with limited documentation within the literature. Between 1984 and 2023, only 40 cases of head and neck squamous cell carcinoma (SCC) with thyroid gland metastasis were described in published literature. Herein, we present a distinctive case of second primary oropharyngeal SCC with metastasis to the thyroid, detected during surveillance positron emission tomography (PET) scanning subsequent to negative margin resection and radiation therapy for SCC originating from the hard palate. The underlying mechanisms overseeing metastasis remain elusive, with hypotheses ranging from lymphatic drainage routes connecting the thyroid gland and retropharyngeal lymph nodes to hematologic dissemination. The management of metastases to the thyroid gland is multifaceted, encompassing approaches ranging from lobectomy and total thyroidectomy to palliative interventions. We present this atypical case alongside supportive pathological and radiological findings and a comprehensive review of this rare clinical entity to offer insight into its diagnosis and management.
摘要：
伴有甲状腺转移的口腔鳞状细胞癌（OSCC）极为罕见，文献中的文献有限。在1984年至2023年之间，发表的文献中仅描述了40例头颈部鳞状细胞癌（SCC）伴甲状腺转移。在这里，我们提出了一个独特的病例，第二原发性口咽SCC转移到甲状腺，在对源自硬腭的SCC进行阴性切缘切除和放射治疗后的正电子发射断层扫描（PET）扫描过程中检测到。监测转移的潜在机制仍然难以捉摸，假设范围从连接甲状腺和咽后淋巴结的淋巴引流途径到血液学播散。甲状腺转移的处理是多方面的，包括从肺叶切除术和甲状腺全切除术到姑息干预的方法。我们介绍了这种非典型病例以及支持性的病理和放射学发现，并对这种罕见的临床实体进行了全面审查，以深入了解其诊断和管理。
