粘液纤维瘤(MF)是一种罕见的,非恶性,具有潜在间充质衍生的牙源性肿瘤。这种特定肿瘤的发生率估计为每年每百万个体约0.05个新病例。MF在10至30岁的年龄范围内表现出更高的发病率。这些肿瘤在女性人群中的患病率较高,下颌骨的主要定位,特别是在后部区域。一位女性患者,66岁,被转介到口腔外科,外科种植和放射学,塞萨洛尼基,希腊,抱怨上颌骨前部有肿瘤性病变和轻度疼痛。临床上,一个实性的触诊分叶肿瘤,在左上切牙观察到正常有色粘膜覆盖。切除活检后,丰富的纤维粘液样基质的微观外观,特别是,粘液样基质与胶原组织混合,被复层鳞状上皮覆盖,提示诊断为周围型黏液纤维瘤。在为期两年的随访中,无复发转诊.此病例说明了对牙龈的每个肿瘤性病变进行适当鉴别诊断以及使用组织病理学检查的必要性。
The myxofibroma (MF) constitutes an uncommon, non-malignant,
odontogenic neoplasm with potential mesenchymal derivation. The occurrence rate of this particular tumor is estimated to be around 0.05 new cases per million individuals annually. MFs exhibit a higher incidence rate within the age range of 10 to 30 years. The prevalence of these tumors is higher among the female population, with a predominant localization in the mandible, specifically in the posterior region. A female patient, 66 years old, was referred to the Department of Oral Surgery, Surgical Implantology and Radiology, Thessaloniki, Greece, complaining of a tumorous lesion in the anterior area of the maxilla and mild pain. Clinically, a solid in palpation lobulated tumor, covered by normal coloured mucosa was observed at the left upper incisor. After the excisional biopsy, the microscopic appearance of abundant fibromyxoid stroma, in particular, myxoid stroma intermingled with collagenous tissue, covered by stratified squamous epithelium, suggested the diagnosis of peripheral myxofibroma. During a 2-year follow-up, no recurrence was referred. This
case illustrates the necessity of proper differential diagnosis of every tumorous lesion of the gingiva and of using the histopathological examination.