Abstract：
Melkersson-Rosenthal syndrome (MRS) is a neuromucocutaneous disease of unknown pathogenesis. With this communication, we describe a case of a 26-year-old woman with complete MRS in whom Mycolicibacterium fortuitum was detected in the swelling lip biopsy by next- generation sequencing. The patient\'s symptoms were slightly improved after intralesional corticosteroid injection combined with broad-spectrum antibiotics, while they were significantly improved after further treatment of dental caries and removal of the residual root. This case provides insight into the possible microbial infection pathogenesis of MRS, and M. fortuitum was speculated to be related to granulomatous and neuronal disorders, most probably from odontogenic origin.
摘要：
Melkersson-Rosenthal综合征（MRS）是一种发病机制未知的神经粘膜皮肤疾病。通过这种交流，我们描述了1例MRS完全的26岁女性患者,该患者通过下一代测序在肿胀的唇活检中检测到了偶然分枝杆菌.病灶内注射糖皮质激素联合广谱抗生素后，患者症状稍有改善，而在进一步治疗龋齿和去除残根后，它们得到了显着改善。该病例提供了对MRS可能的微生物感染发病机制的见解，推测M.fortuitum与肉芽肿和神经元疾病有关，很可能来自牙源性。
