介绍用真皮填充剂增加嘴唇的受欢迎程度正在上升。通常有轻微和短暂的副作用。然而,可能会出现长期并发症,包括肿块,颠簸,结节,或者肉芽肿.为了更好地理解这个不寻常但具有挑战性的结果,我们的目标是对已发表的与嘴唇美容软组织增强后结节或肉芽肿形成相关的文献进行全面的系统回顾。方法根据2021年4月的PRISMA(系统评价和荟萃分析的首选报告项目)指南,对已发表的文献进行了检索,包括PubMed,ScienceDirect,Embase,谷歌学者,和Cochrane数据库。使用的医学主题词(MeSH)术语包括以下术语:“嘴唇填充物,\"\"透明质酸,\"\"唇注射,\"\"增唇,\"\"硅胶,\"\"聚-L-乳酸,“\”羟基磷灰石钙,\"\"聚甲基丙烯酸甲酯,“\”并发症,\"\"反应,\"\"肉芽肿,\"和\"结节。“所有研究均由两名独立评审员审查。任何差异都由第三位审阅者解决。结果对填充物相关结节或肉芽肿的初步搜索产生了2,954篇文章,其中28篇纳入最终分析,包含66例嘴唇结节。除一名患者外,其余均为女性。平均年龄为50岁。初始治疗后平均35.2个月或2.9年出现结节。37个结节进行了组织学分析,其中大多数确定存在异物肉芽肿。硅酮是使用最多的报道的填充剂,其次是透明质酸。大多数病例在多种治疗后解决,包括口服抗生素或类固醇,然后进行手术切除。结论了解填充产品丰唇的后遗症可以使临床医生提供安全有效的治疗方法。皮肤治疗后数月至数年出现的结节可能代表异物肉芽肿。口服抗生素的组合,病灶内或口服类固醇,在我们的研究中,手术切除成功治疗了大多数病例。
Introduction Lip augmentation with dermal filler is rising in popularity. There are generally minimal side effects that are mild and transient. However, long-term complications may occur and include lumps, bumps,
nodules, or granulomas. To better understand this uncommon but challenging outcome, we aim to perform a thorough systematic
review of the published literature related to nodule or granuloma formation after cosmetic soft tissue augmentation of the lips. Methods A search of published literature was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines in April 2021 and included PubMed, ScienceDirect, Embase, Google Scholar, and Cochrane databases. The Medical Subject Headings (MeSH) terms used included the following terms: \"lip filler,\" \"hyaluronic acid,\" \"lip injection,\" \"lip augmentation,\" \"silicone,\" \"poly-L-lactic acid,\" \"calcium hydroxyapatite,\" \"polymethylmethacrylate,\" \"complications,\" \"reaction,\" \"granuloma,\" and \"nodule.\" All studies were reviewed by two independent reviewers. Any discrepancies were resolved by a third reviewer. Results The initial search for filler-related nodules or granulomas yielded 2,954 articles and 28 were included in the final analysis containing 66 individual cases of lip
nodules. All but one patient was female. The mean age was 50 years.
Nodules presented on average 35.2 months or 2.9 years after initial treatment. Thirty-seven
nodules underwent histological analysis, the majority of which identified the presence of a foreign-body granuloma. Silicone was the most reported filler used followed by hyaluronic acid. Most cases resolved following multiple treatments including oral antibiotics or steroids followed by surgical excision. Conclusion Understanding the sequelae of lip augmentation with filler products allows clinicians to provide safe and effective treatment. Nodules that present months to years following dermal treatment may represent a foreign-body granuloma. A combination of oral antibiotics, intralesional or oral steroids, and surgical excision successfully treated the majority of cases in our study.