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Abstract：
Plasma cell leukemia (PCL) is a rare variant of leukemia with an aggressive clinical course and a poor prognosis. The cutaneous involvement in PCL is very rare either at clinical presentation of leukemia, namely leukemia cutis, or in the metastatic PCL to the skin. We present a case of eruptive multiple cutaneous nodules in a 56-year-old man with metastatic PCL. Histologically, a diffuse dermal and subcutaneous infiltration of ovoid cells with amphophilic cytoplasm and eccentrically located nucleus consistent with plasmacytoid morphology was observed. Neoplastic cells showed strong immunoexpression for CD138 and CD38 consistent with plasma cells phenotype, and loss of expression of CD56. Kappa light chain restriction similar to the phenotype of his PCL was demonstrated. We suggest that the evaluation of new skin lesions in leukemic patients should include a histopathologic examination to establish the diagnosis as soon as possible and a correct management of the disease.
摘要：
浆细胞白血病（PCL）是白血病的一种罕见变体，具有侵袭性的临床病程和不良的预后。在白血病的临床表现中，PCL的皮肤受累非常罕见，即皮肤白血病，或在皮肤的转移性PCL中。我们介绍了一例56岁的转移性PCL患者的多发皮肤结节。组织学上,观察到弥漫性的真皮和皮下卵圆形细胞浸润，具有两性的细胞质和偏心定位的核与浆细胞样形态一致。肿瘤细胞显示CD138和CD38的强免疫表达与浆细胞表型一致，和CD56表达的丧失。证明了与他的PCL表型相似的κ轻链限制。我们建议对白血病患者的新皮肤病变的评估应包括组织病理学检查，以尽快确定诊断并正确处理疾病。
