■Opsoclonus是一种罕见的疾病,其特征是共轭多向,水平,垂直,和扭转扫视振荡,没有间隔间隔,由脑干和小脑复杂神经元通路内的功能障碍引起。虽然大多数病例的视阵挛症与自身免疫性或副肿瘤性疾病有关,传染剂,创伤,或者保持特发性,也可由影响神经传递的药物引起。这项审查是由一例多系统萎缩患者发生的视阵挛症引起的,金刚烷胺,NMDA受体拮抗剂,似乎诱导了视阵阵。
■一名患者的病例报告和毒性/药物诱导的视阵挛症的系统化综述,根据预定义的标准选择文章,并评估纳入研究的质量。
■该综述包括30篇文章,包括158例毒性/药物诱导的视阵挛症。74%的病例归因于树皮蝎子中毒,其次是9%的与十氯酮中毒相关的病例。其余病例是由于各种毒物/药物,强调各种神经递质的参与,包括乙酰胆碱,谷氨酸,GABA,多巴胺,甘氨酸,和钠通道,在发育中。
■毒性/药物诱导的视阵痛非常罕见。影响不同神经递质系统的毒物/药物的多样性使得定义统一机制具有挑战性。考虑到复杂的神经元通路,这些通路是眼球运动生理学和视阵阵病理生理学的基础。
UNASSIGNED: Opsoclonus is a rare disorder characterized by conjugate multidirectional, horizontal, vertical, and torsional saccadic oscillations, without intersaccadic interval, resulting from dysfunction within complex neuronal pathways in the brainstem and cerebellum. While most cases of opsoclonus are associated with autoimmune or paraneoplastic disorders, infectious agents, trauma, or remain idiopathic, opsoclonus can also be caused by medications affecting neurotransmission. This review was prompted by a
case of opsoclonus occurring in a patient with Multiple System Atrophy, where amantadine, an NMDA-receptor antagonist, appeared to induce opsoclonus.
UNASSIGNED: Case report of a single patient and systematized review of toxic/drug-induced opsoclonus, selecting articles based on predefined criteria and assessing the quality of included studies.
UNASSIGNED: The review included 30 articles encompassing 158 cases of toxic/drug-induced opsoclonus. 74% of cases were attributed to bark scorpion poisoning, followed by 9% of cases associated with chlordecone intoxication. The remaining cases were due to various toxics/drugs, highlighting the involvement of various neurotransmitters, including acetylcholine, glutamate, GABA, dopamine, glycine, and sodium channels, in the development of opsoclonus.
UNASSIGNED: Toxic/drug-induced opsoclonus is very rare. The diversity of toxics/drugs impacting different neurotransmitter systems makes it challenging to define a unifying mechanism, given the intricate neuronal pathways underlying eye movement physiology and opsoclonus pathophysiology.