背景:步态和行动障碍是帕金森病的关键标志,在非典型帕金森病包括多系统萎缩(MSA)和进行性核上性麻痹(PSP)中尤其严重。一项初步研究表明,经过物理治疗和匹配的家庭锻炼后,帕金森病型MSA(MSA-P)患者的步态显着改善,由基于传感器的步态参数反映。在这项研究中,我们旨在调查与标准物理治疗/基于家庭的运动计划相比,以步态为中心的物理治疗(GPT)和匹配的基于家庭的运动是否会导致步态表现的更大改善(标准物理治疗,SPT)。
方法:该方案用于评估GPT与主动对照进行SPT和匹配基于家庭的运动在实验室步态参数方面的效果,帕金森病(PD)患者的身体活动测量和临床量表,MSA-P和PSP。试验的主要结果是基于传感器的实验室步态参数,而次要结果测量包括现实世界推导的参数,临床评定量表和患者问卷。我们的目标是每个疾病组招募48名患者进入这种双盲,随机对照试验。该研究从1周的基于可穿戴传感器的身体活动监测开始。随机化后,患者每天接受2周的住院理疗,接下来是5周匹配无监督的家庭培训。在干预的最后一周重复1周的身体活动监测。
背景:本研究,在clinicaltrials.gov(NCT04608604)注册为“非典型帕金森病的流动性:物理治疗试验(Mobility_APP)”,获得了相关中心地方委员会的伦理批准。患者的招募发生在因斯布鲁克(奥地利)的运动障碍单位,埃尔兰根(德国),洛桑(瑞士),卢森堡(卢森堡)和博尔扎诺(意大利)。该项目产生的数据将提交给同行评审的期刊,在国际大会上提出,并在审判结束时公开提供。
背景:NCT04608604。
BACKGROUND: Gait and mobility impairment are pivotal signs of parkinsonism, and they are particularly severe in atypical parkinsonian disorders including multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A pilot
study demonstrated a significant improvement of gait in patients with MSA of parkinsonian type (MSA-P) after physiotherapy and matching home-based exercise, as reflected by sensor-based gait parameters. In this
study, we aim to investigate whether a gait-focused physiotherapy (GPT) and matching home-based exercise lead to a greater improvement of gait performance compared with a standard physiotherapy/home-based exercise programme (standard physiotherapy, SPT).
METHODS: This protocol was deployed to evaluate the effects of a GPT versus an active control undergoing SPT and matching home-based exercise with regard to laboratory gait parameters, physical activity measures and clinical scales in patients with Parkinson\'s disease (PD), MSA-P and PSP. The primary outcomes of the trial are sensor-based laboratory gait parameters, while the secondary outcome measures comprise real-world derived parameters, clinical rating scales and patient questionnaires. We aim to enrol 48 patients per disease group into this double-blind, randomised-controlled
trial. The
study starts with a 1 week wearable sensor-based monitoring of physical activity. After randomisation, patients undergo a 2 week daily inpatient physiotherapy, followed by 5 week matching unsupervised home-based training. A 1 week physical activity monitoring is repeated during the last week of intervention.
BACKGROUND: This
study, registered as \'Mobility in Atypical Parkinsonism: a
Trial of Physiotherapy (Mobility_APP)\' at clinicaltrials.gov (NCT04608604), received ethics approval by local committees of the involved centres. The patient\'s recruitment takes place at the Movement Disorders Units of Innsbruck (Austria), Erlangen (Germany), Lausanne (Switzerland), Luxembourg (Luxembourg) and Bolzano (Italy). The data resulting from this project will be submitted to peer-reviewed journals, presented at international congresses and made publicly available at the end of the trial.
BACKGROUND: NCT04608604.