UNASSIGNED: Case report of a single patient and systematized review of toxic/drug-induced opsoclonus, selecting articles based on predefined criteria and assessing the quality of included studies.
UNASSIGNED: The review included 30 articles encompassing 158 cases of toxic/drug-induced opsoclonus. 74% of cases were attributed to bark scorpion poisoning, followed by 9% of cases associated with chlordecone intoxication. The remaining cases were due to various toxics/drugs, highlighting the involvement of various neurotransmitters, including acetylcholine, glutamate, GABA, dopamine, glycine, and sodium channels, in the development of opsoclonus.
UNASSIGNED: Toxic/drug-induced opsoclonus is very rare. The diversity of toxics/drugs impacting different neurotransmitter systems makes it challenging to define a unifying mechanism, given the intricate neuronal pathways underlying eye movement physiology and opsoclonus pathophysiology.
■一名患者的病例报告和毒性/药物诱导的视阵挛症的系统化综述,根据预定义的标准选择文章,并评估纳入研究的质量。
■该综述包括30篇文章,包括158例毒性/药物诱导的视阵挛症。74%的病例归因于树皮蝎子中毒,其次是9%的与十氯酮中毒相关的病例。其余病例是由于各种毒物/药物,强调各种神经递质的参与,包括乙酰胆碱,谷氨酸,GABA,多巴胺,甘氨酸,和钠通道,在发育中。
■毒性/药物诱导的视阵痛非常罕见。影响不同神经递质系统的毒物/药物的多样性使得定义统一机制具有挑战性。考虑到复杂的神经元通路,这些通路是眼球运动生理学和视阵阵病理生理学的基础。