目的:探讨眶周黑变病(POM)与胰岛素抵抗(IR)及血清维生素D水平的关系。
方法:在本试验中,病例对照研究,我们纳入了100例成人POM患者和100例年龄和性别匹配的健康对照受试者.维生素D水平和IR指数(即,稳态模型评估-胰岛素抵抗[HOMA-IR],甘油三酯/高密度脂蛋白胆固醇(TG/HDL-c)比值,在病例和对照组之间比较脂联素/瘦素(A/L)比率)。
结果:与对照组相比,POM病例的HOMA-IR和TG/HDL-c比值明显较高,HOMA-IR和TG/HDL-c比值与POM严重程度呈显著正相关,而维生素D和A/L比值呈显著负相关。
结论:POM与IR和维生素D缺乏相关。然而,POM之间的确切因果联系,IR,需要建立维生素D。然而,这项初步研究的结果表明,POM可能具有作为这些代谢紊乱的皮肤非侵入性标志物的潜力,这将有助于在早期发现和治疗这些代谢紊乱.
OBJECTIVE: To investigate the possible association of periorbital
melanosis (POM) with insulin resistance (IR) and vitamin D serum levels.
METHODS: In this pilot,
case-control study, we included 100 adult patients with POM and 100 age- and sex-matched healthy control subjects. Vitamin D levels and IR indices (i.e., homeostatic model assessment-insulin resistance [HOMA-IR], triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) ratio, adiponectin/leptin (A/L) ratio) were compared between cases and controls.
RESULTS: Compared with controls, POM cases had significantly higher values of HOMA-IR and TG/HDL-c ratio, and significantly lower values of A/L and vitamin D. HOMA-IR and TG/HDL-c ratio were statistically significantly positively correlated with POM severity while Vitamin D and A/L ratio were statistically significantly negatively correlated.
CONCLUSIONS: POM was associated with indices of IR and vitamin D deficiency. However, the exact causal link among POM, IR, and vitamin D needs to be established. However, the results of this pilot study suggest that POM may have potential as a cutaneous non-invasive marker of these metabolic disorders which would assist in detecting and treating them at an early stage.