PDF(Pubmed)
Abstract：
Melanosis, the aberrant deposition of melanin pigment in the absence of melanocytes, is very rare in the genitourinary tract. We report a case of a 74-year-old male with symptomatic benign prostatic hyperplasia. Diagnostic cystourethroscopy demonstrated bladder mucosa remarkable for numerous flat, velvety, and brown-black lesions. The patient underwent cystolitholapaxy, transurethral resection of the prostate, and bladder biopsy. Microscopic examination of the bladder biopsy demonstrated urothelium with granular, black pigmentation within the mucosa and histiocytes in the lamina propria; a Fontana Masson stain was positive for melanin. Microscopic examination of the transurethral resection of the prostate demonstrated nodular hyperplasia with focal, black pigmentation of the stroma. The rarity of bladder and prostate melanosis highlights the need for further investigation to elucidate its clinical significance and provide assurance of its benignity. Despite its rarity, melanosis should be kept in the differential diagnosis when melanotic lesions are encountered during cystoscopy.
摘要：
黑变病,在没有黑素细胞的情况下黑色素的异常沉积，在泌尿生殖道非常罕见。我们报告了一例74岁的男性，有症状的良性前列腺增生。诊断性膀胱尿道镜检查显示膀胱粘膜显着许多扁平，天鹅绒般的,和棕黑色病变。患者接受了膀胱结石，经尿道前列腺切除术,膀胱活检.膀胱活检的显微镜检查显示尿路上皮颗粒，粘膜和固有层组织细胞内的黑色色素沉着；FontanaMasson染色对黑色素呈阳性。经尿道前列腺电切术的显微镜检查显示结节状增生，基质的黑色色素沉着。膀胱和前列腺黑变病的罕见性凸显了进一步研究的必要性，以阐明其临床意义并确保其良性。尽管它很罕见,当在膀胱镜检查中遇到黑色素病变时，应将黑色素沉着保留在鉴别诊断中。
