PDF(Pubmed)
Abstract：
Riehl\'s melanosis is a pigmented dermatitis that manifests as brown-gray facial pigmentation with pigment incontinence and infiltration of cells in the upper dermis. The associated inflammation is induced by a variety of products such as drugs and cosmetics. Henna, commonly referred to as a hypoallergenic cosmetic, has been reported to cause Riehl\'s melanosis in some cases. Although skin depigmenting agents have been occasionally used, satisfactory results have not been obtained and no established therapeutic strategies exist to treat Riehl\'s melanosis. Meanwhile, picosecond lasers effectively treat other hyperpigmentation disorders. In this study, we report safe and effective treatment of henna induced-atypical Riehl\'s melanosis using a 755-nm picosecond Alexandrite laser. Immunohistochemical analyses revealed a potential role of CD8-positive lymphocytes in henna-induced inflammation and hyperpigmentation of the basal layer, and a role of melanophages in the pigmented dermis of Riehl\'s melanosis.
摘要：
Riehl黑变病是一种色素性皮炎，表现为棕灰色面部色素沉着伴色素失禁和真皮上部细胞浸润。相关的炎症是由各种产品如药物和化妆品引起的。指甲花,通常被称为低过敏性化妆品，据报道在某些情况下会导致Riehl黑变病。尽管偶尔使用皮肤脱色剂，尚未获得令人满意的结果，也没有确定的治疗Riehl黑变病的治疗策略。同时,皮秒激光可有效治疗其他色素沉着过度疾病。在这项研究中,我们报告了使用755nm皮秒翠绿宝石激光治疗指甲花诱导的非典型Riehl黑变的安全有效。免疫组织化学分析揭示了CD8阳性淋巴细胞在指甲花诱导的炎症和基底层色素沉着中的潜在作用。和黑色素细胞在Riehl黑变病的色素真皮中的作用。
